| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
We clarified that a membrane skeletal 4.1 family, 4.1G, is involved in Schmidt-Lanterman incisure in myelin of Schwann cells, and have roles in sorting of membrane protein palmitoylated (MPP) 6, cell adhesion molecule (CADM) 4 and phosphorylation of Src. In vivo cryotechnique revealed beaded appearance and protective reaction of the incisures in stretched peripheral nerve fibers, as well as accurate localization of albumin. In addition, we analyzed relationship between the 4.1 and MPP families in mouse intestinal epithelial cells.
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