Analyses of protein complex in Schwann cell membrane skeletal structures
Project/Area Number |
25460267
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General anatomy (including histology/embryology)
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Research Institution | Shinshu University |
Principal Investigator |
TERADA Nobuo 信州大学, 学術研究院保健学系, 教授 (60293461)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 膜骨格 / シュワン細胞 / 凍結技法 / 末梢神経系 / 末梢神経 / 腸管 / 接着分子 / 蛋白複合体 / 細胞極性 |
Outline of Final Research Achievements |
We clarified that a membrane skeletal 4.1 family, 4.1G, is involved in Schmidt-Lanterman incisure in myelin of Schwann cells, and have roles in sorting of membrane protein palmitoylated (MPP) 6, cell adhesion molecule (CADM) 4 and phosphorylation of Src. In vivo cryotechnique revealed beaded appearance and protective reaction of the incisures in stretched peripheral nerve fibers, as well as accurate localization of albumin. In addition, we analyzed relationship between the 4.1 and MPP families in mouse intestinal epithelial cells.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] Involvement of the Tyro3 receptor and its intracellular partner Fyn signaling in Schwann cell myelination.2015
Author(s)
Miyamoto Y, Torii T, Takada S, Ohno N, Saitoh Y, Nakamura K, Ito A, Ogata T, Terada N, Tanoue A, Yamauchi J.
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Journal Title
Mol Biol Cell.
Volume: 26
Pages: 3489-3503
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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