| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
In this project, roles of primitive epicardium against the myocardial development before the onset of coronary circulation was investigated; and a cardiomyocyte injury model was established to examine the restoration process of the injured cardiomyocytes during development. Primitive epicardium was required for proper development of the compact ventricular layer and the signaling molecules regulating the cardiomyocyte differentiation and maturation were FGF and TGFβ. The investigator also established cryoinjury model of the developing heart during embryogenesis. The restoration process of the injured heart included formation of the clot, scar formation, scar contraction and cardiomyocyte hypertrophy surrounding the injury. Neither cardiomyocyte proliferation nor regeneration was observed at the acute phase of restoration. Further experiments are necessary to elucidate the mechanisms underlying the restoration of the injured heart during development.
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