| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
It has been recently identified that the transmembrane protein (TMEM) 16A functions as a calcium-activated anion channels. On the other hand, TMEM16F, a member of the TMEM16 family, is demonstrated to transport phospholipids as a scramblase. We demonstrated, in the present study, that TMEM16F functions as not only phospholipid scramblases but also calcium-activated anion channels. In addition, we clarified that both TMEM16F functions are closely related. We therefore suggested that TMEM16F is a unique membrane protein exhibiting two different membrane transports.
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