Functional coupling between ion channels and scramblases in human TMEM16F-expressing cells
Project/Area Number |
25460282
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General physiology
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Research Institution | University of Toyama |
Principal Investigator |
SHIMIZU TAKAHIRO 富山大学, 大学院医学薬学研究部(薬学), 准教授 (40353437)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | TMEM16F / イオンチャネル / スクランブラーゼ / ヒトTMEM16F / ヒトTMEM16F / ホスファチジルセリン / Ca2+ |
Outline of Final Research Achievements |
It has been recently identified that the transmembrane protein (TMEM) 16A functions as a calcium-activated anion channels. On the other hand, TMEM16F, a member of the TMEM16 family, is demonstrated to transport phospholipids as a scramblase. We demonstrated, in the present study, that TMEM16F functions as not only phospholipid scramblases but also calcium-activated anion channels. In addition, we clarified that both TMEM16F functions are closely related. We therefore suggested that TMEM16F is a unique membrane protein exhibiting two different membrane transports.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Functional coupling of chloride-proton exchanger C1C-5 to gastric H +, K <+->ATPase.2014
Author(s)
Takahashi Y, Fujii T, Fujita K, Shimizu T, Higuchi T, Tabuchi Y, Sakamoto H, Naito I, Manabe K, Uchida S, Sasaki S, Ikari A, Tsukada K, Sakai H.
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Journal Title
Biol. Open
Volume: 3巻
Issue: 1
Pages: 12-21
DOI
Related Report
Peer Reviewed
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