Elucidation of the shared signaling pathways for intractable diseases in terms of cytoskeletal rearrangements
| Project/Area Number |
25460290
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
KISHI Hiroko 山口大学, 医学(系)研究科(研究院), 准教授 (40359899)
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| Co-Investigator(Kenkyū-buntansha) |
KAJIYA Katsuko 鹿児島大学, 農学部, 講師 (00379942)
KOBAYASHI Sei 山口大学, 大学院医学系研究科, 教授 (80225515)
ZHANG Ying 山口大学, 大学院医学系研究科, 助教 (10711260)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 血管平滑筋 / 血管異常収縮 / 細胞骨格関連分子 / 細胞運動・遊走 / 病的シグナル伝達系 / 腫瘍細胞浸潤・転移 |
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| Outline of Final Research Achievements |
The results of this research are summarized as follows: 1) We determined the site of P1, a cytoskeleton-related molecule, where interacts with Fyn, a signaling molecule which mediates abnormal contraction of vascular smooth muscle. 2) We found that V1, a cytoskeleton-related molecule, was tyrosine-dephosphorylated and cleaved at the N-terminus by the stimulation of SPC. 3) We found that the knockdown of P1 inhibited the stress-fiber formation and cell migration. 4) We found that P1 has multiple phosphorylation sites and the time course of phosphorylation was different in each site. 5) We generated smooth muscle-specific P1 knockout mice.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Fatty acid-binding protein 7 regulates function of caveolae in astrocytes through expression of caveolin-12015
Author(s)
Yoshiteru Kagawa, Yuki Yasumoto, Kazem Sharifi, Majid Ebrahimi, Ariful Islam, Hirofumi Miyazaki, Yui Yamamoto, Tomoo Sawada, Hiroko Kishi, Sei Kobayashi, Motoko Maekawa, Takeo Yoshikawa, Eiichi Takaki, Akira Nakai, Hiroshi Kogo, Toyoshi Fujimoto, Yuji Owada
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Journal Title
Glia
Volume: 63
Pages: 780-794
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Interaction of peptide-bound beads with lipopolysaccharide and lipoproteins.2014
Author(s)
Suzuki,M.M.,Matsumoto,M.,Omi,H.,Kobayashi,T.,Nakamura, A.,Kishi,H.,Kobayashi, S., and Takagi, T.
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Journal Title
J Microbiol Methods.
Volume: 100
Pages: 137-141
DOI
Related Report
Peer Reviewed
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