Sympathetic nerve control with the voltage-dependent calcium channel beta subunits.
Project/Area Number |
25460293
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General physiology
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Research Institution | Hirosaki University |
Principal Investigator |
murakami manabu 弘前大学, 医学(系)研究科(研究院), 教授 (80302090)
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Co-Investigator(Kenkyū-buntansha) |
ONO Kyoichi 秋田大学, 大学院医学研究科, 教授 (70185635)
OHBA Takayoshi 秋田大学, 大学院医学研究科, 助教 (80431625)
SUGITA Chiharu 九州保健福祉大学, 薬学部, 助教 (70632694)
FURUKAWA Kennnichi 弘前大学, 大学院医学研究科, 准教授 (20165468)
SEYA Kazuhiko 弘前大学, 大学院医学研究科, 助教 (40281919)
柳田 俊彦 宮崎大学, 医学部, 教授 (60295227)
根本 隆行 宮崎大学, 医学部, 助教 (90506833)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | calcium / channel / mouse / sympathetic nerve / カルシウム / マウス / 遺伝子 / チャネル / ECG / phosphorylation |
Outline of Final Research Achievements |
The P/Q-type channels are composed principally of heterologous multimeric subunits including CaV2.1 and CaVβ4. ECG analysis showed that the T wave was high in 8-week-old lh mutants (CaVβ4-null mice). Upon pharmacological ECG analysis, lh mutants exhibited reduced responses to a β-blocker and a muscarinic receptor antagonist. Analysis of heart rate variability revealed that the R-R interval was unstable in lh mutants and that both the low- and high-frequency components had increased in extent, indicating that the tonus of both the sympathetic and parasympathetic nervous systems was modified. We also analyzed calcium channel modifying factors, such as histamine receptor and Orexin, which is neural peptide. With Histamine receptor type 1-null mice, we found signify involvement of H1 receptor in the sympathetic nerve regulation. We also found involvement of Orexin system in the sympathetic nerve control.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Involvement of the histamine H1 receptor in the regulation of sympathetic nerve activity.2015
Author(s)
Murakami M, Yoshikawa T, Nakamura T, Ohba T, Matsuzaki Y, Sawamura D, Kuwasako K, Yanagisawa T, Ono K, Nakaji S, Yanai K.
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Journal Title
Biochem Biophys Res Commun.
Volume: 458
Issue: 3
Pages: 584-589
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Shintaku T, Ohba T, Niwa H, Kushikata T, Hirota K, Ono K, Matsuzaki Y, Imaizumi T, Sawamura D, Murakami M.2015
Author(s)
Shintaku T, Ohba T, Niwa H, Kushikata T, Hirota K, Ono K, Matsuzaki Y, Imaizumi T, Sawamura D, Murakami M.
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Journal Title
Hirosaki Medical Journal
Volume: 66
Pages: 1-7
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Comparison of the Effects of Isoflurane Inhalation, Pentobarbital and a Medetomidine-Midazolam-Butorphanol Combination Anesthesia on Electrocardiograms in Mice2015
Author(s)
Shintaku T, Ohba T, Niwa H, Kushikata T, Hirota K, Ono K, Matsuzaki Y, Imaizumi T, Sawamura D, Murakami M.
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Journal Title
Hirosaki Medical Journal
Volume: 66
Pages: 14-20
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Modified autonomic regulation in mice mutated in the beta4 subunit of the lh/lh calcium channel.2015
Author(s)
Murakami M, Suzuki T, Wu T-W, Kuwasako K, Takahashi E, Watanabe H, Murakami AM, Miyoshi I, Yanagisawa T, Sasano H, Ono K, Ohba T.
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Journal Title
Biochem Biophys Res Commun.
Volume: in press
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Involvement of the orexin system in sympathetic nerve regulation2015
Author(s)
Murakami M, Ohba T, Kushikata T, Niwa H, Kurose A, Imaizumi T, Watanabe H, Yanagisawa T, Nakaji S, Ono K, Hirota K.
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Journal Title
Biochem Biophys Res Commun.
Volume: in press
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Desferrioxamine, an iron chelator, inhibits CXCL10 expression induced by polyinosinic-polycytidylic acidin U373MG human astrocytoma cells.2015
Author(s)
Imaizumi T, Sakashita N, Mushiga Y, Yoshida H, Hayakari R, Xing F, Wang L, Matsumiya T, Tanji K, Chiba Y, Furudate K, Kawaguchi S, Murakami M, Tanaka H.
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Journal Title
Neurosci Res.
Volume: in press
Pages: 10-16
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Effects of Propofol on Electrocardiogram Measures in Mice2014
Author(s)
Shintaku T, Ohba T, Niwa H, Kushikata T, Hirota K, Ono K, Matsuzaki Y, Imaizumi T, Kuwasako K, Sawamura D, Murakami M.
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Journal Title
Journal of Pharmacological Sciences
Volume: 126
Issue: 4
Pages: 351-358
DOI
NAID
ISSN
1347-8613, 1347-8648
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] ISG54 and ISG56 are induced by TLR3 signaling in U373MG human astrocytoma cells: Possible involvement in CXCL10 expression.2014
Author(s)
Imaizumi T, Numata A, Yano C, Yoshida H, Meng P, Hayakari R, Xing F, Wang L, Matsumiya T, Tanji K, Tatsuta T, Murakami M, Tanaka H.
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Journal Title
Neurosci Res
Volume: 000
Pages: 34-42
DOI
Related Report
Peer Reviewed
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[Presentation] Modified autonomic regulation in mice mutated in the beta4 subunit of the lh/lh calcium channel.2015
Author(s)
Murakami M, Suzuki T, Wu T-W, Kuwasako K, Takahashi E, Watanabe H, Murakami AM, Miyoshi I, Yanagisawa T, Sasano H, Ono K, Ohba T.
Organizer
第92回 日本生理学会大会
Place of Presentation
神戸
Year and Date
2015-03-21 – 2015-03-23
Related Report
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