| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
We found that the salt-sensitivity of blood pressure was attenuated in Epac1 deficient mice. In addition, the aquaporin 2 (AQP2) and renin mRNA levels in the kidney of EPAC1KO mice were significantly lower than that in wild type (WT) mice. Consistently, water consumption was increased in the mice compare to WT mice, indicating that water reabsorption through AQP2 may be inhibited by EPAC1 deficiency.
These findings suggest that EPAC1 plays important role in maintaining the expression of renin and AQP2 in the kidney of mice. Through these mechanisms, Epac1 may be involved in the development of hypertension.
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