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Identification of bone formation mechanisms at resorption lacunae

Research Project

Project/Area Number 25460300
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General physiology
Research InstitutionKeio University

Principal Investigator

Kuroda Yukiko  慶應義塾大学, 医学部, 助教 (70455343)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords骨形成 / 糖鎖修飾 / 骨吸収窩 / 破骨細胞 / 骨芽細胞 / 糖タンパク質
Outline of Final Research Achievements

Abundant glycoproteins exist in bone resorption pits, whereas their physiological roles remain unknown. In this study, I observed that glycoproteins sticking to the surface of resorption pits were produced by mature osteoclasts, but not osteoclast precursors. I also found a novel lectin that tightly bound to a bone reporption pit by lectin microarray analysis, and this lectin specifically recognized osteoclasts and blood vessels in vivo. Matrix metalloproteinase was identified as a major protein that bound to the lectin in those mature osteoclast secreted. Finally, the osteoblast culture experiment suggested the possibility that bone resorption pits could modulate osteoblast migration.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (7 results)

All 2015 2014

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (5 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Osteoprotegerin Regulates Pancreatic β-Cell Homeostasis upon Microbial Invasion.2015

    • Author(s)
      Yukiko Kuroda, Kenta Maruyama, Hideki Fujii, Isamu Sugawara, Shigeru Ko, Hisataka Yasuda, Hidenori Matsui, and Koichi Matsuo
    • Journal Title

      PLoS One

      Volume: 11 Issue: 1 Pages: e0146544-e0146544

    • DOI

      10.1371/journal.pone.0146544

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Osteogenic capillaries orchestrate growth plate-independent ossification of the malleus2015

    • Author(s)
      Matsuo K, Kuroda Y, Nango N, Shimoda K, Kubota Y, Ema M, Bakiri L, Wagner EF, Takeda Y, Yashiro W, Momose A
    • Journal Title

      Development

      Volume: 142 Pages: 3912-20

    • DOI

      10.1242/dev.123885

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Sialylated Glycans of MMP-9 Mark Bone Resorption Lacunae2015

    • Author(s)
      Yukiko Kuroda, Atsushi Kuno, Hisashi Narimatsu, Koichi Matsuo
    • Organizer
      American Society for Bone and Mineral Research
    • Place of Presentation
      Seattle, Washington, USA
    • Year and Date
      2015-10-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Osteoprotegerin(OPG)は感染時におけるインスリン放出を阻害し、インスリン枯渇を防いでいる2015

    • Author(s)
      黒田 有希子、松尾 光一
    • Organizer
      日本骨代謝学会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2015-07-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] 3Dイメージングによる頭部骨のallometricな成長の観察2015

    • Author(s)
      枝元美緒、黒田有希子、松尾光一
    • Organizer
      日本骨代謝学会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2015-07-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] イノシトール三リン酸受容体を介したカルシウムオシレーション依存的および非依存的破骨細胞分化制御メカニズム2015

    • Author(s)
      黒田有希子
    • Organizer
      日本薬理学会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-03-18 – 2015-03-20
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 感染時において、Osteoprotegerin (OPG)は骨だけではなく膵臓の保護にも貢献している2014

    • Author(s)
      黒田有希子
    • Organizer
      日本骨代謝学会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2014-07-24 – 2014-07-26
    • Related Report
      2014 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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