Regulation of intestinal motility by lipid intake via LRP1

• Project/Area Number: 25460301
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General physiology
• Research Institution: Keio University
• Principal Investigator: Masaoka Tatsuhiro 慶應義塾大学, 医学部, 講師 (00317132)
• Co-Investigator(Kenkyū-buntansha): Suzuki Hidekazu 慶應義塾大学, 医学部, 教授 (70255454)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 消化管運動 / LRP1 / 脂質代謝 / 消化管神経叢

Outline of Final Research Achievements

In this study, conditional deletion of LRP1 gene in neural crest derived region which include enteric nervous system showed intestinal dysmotility. This study suggest relationship between LRP1 and intestinal motility.

Research Products

• [Journal Article] Emerging treatments in neurogastroenterology: Acotiamade, a novel treatment option for functional dyspepsia (2016)
  • Author(s): Matsushita M., Masaoka T., Suzuki H.
  • Journal Title: Neurogastroenterol Motil. Volume: 28 Issue: 5 Pages: 631-8
  • DOI: 10.1111/nmo.12756
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The normoglycaemic biobreeding rat: a spontaneous model for impaired gastric accommodation (2015)
  • Author(s): Vanormelingen C., Vanuytsel T., Masaoka T., De Hertogh G., Vanheel H., Vanden Berghe P., Farré R., Tack J.
  • Journal Title: Gut Volume: 65 Issue: 1 Pages: 73-81
  • DOI: 10.1136/gutjnl-2014-308154
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Nordihydroguaiaretic acid disrupts the antioxidant ability of Helicobacter pylori through the repression of SodB activity in vitro. (2015)
  • Author(s): Tsugawa, H., Mori, H., Matsuzaki, J., Masaoka, T., Hirayama, T., Nagasawa, H., Sakakibara, Y., Suematsu, M., Suzuki, H.
  • Journal Title: Biomed. Res. Int. Volume: 2015 Pages: 734548-734548
  • DOI: 10.1155/2015/734548
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A spontaneous animal model of intestinal dysmotility evoked by inflammatory nitrergic dysfunction (2014)
  • Author(s): Masaoka T, Vanuytsel T, Vanormelingen C, Kindt S, Salim Rasoel S, Boesmans W, De Hertogh G, Farre R, Vanden Berghe P, Tack J
  • Journal Title: PLoS One Volume: 9 Issue: 5 Pages: e95879-e95879
  • DOI: 10.1371/journal.pone.0095879
  • Peer Reviewed / Open Access
• [Journal Article] From intestinal permeability to dysmotility: the biobreeding rat as a model for functional gastrointestinal disorders (2014)
  • Author(s): Vanuytsel T, Vanormelingen C, Vanheel H, Masaoka T, Salim Rasoel S, Toth J, Houben E, Verbeke K, De Hertogh G, Vanden Berghe P, Tack J, Farre R.
  • Journal Title: PLoS One Volume: 9 Issue: 10 Pages: e111132-e111132
  • DOI: 10.1371/journal.pone.0111132
  • Peer Reviewed / Open Access
• [Journal Article] Greater loss of productivity among Japanese workers with gastroesophageal reflux disease (GERD) symptoms that persist vs resolve on medical therapy. (2014)
  • Author(s): Suzuki, H., Matsuzaki, J., Masaoka, T., Inadomi, J.M.
  • Journal Title: Neurogastroenterol. Motil. Volume: - Issue: 6 Pages: 764-771
  • DOI: 10.1111/nmo.12319
  • Peer Reviewed / Open Access
• [Journal Article] Does the AIMS65, a new risk score for upper gastrointestinal bleeding, work in Japan? (2014)
  • Author(s): Masaoka, T., Suzuki, H.
  • Journal Title: Digest. Endosc. Volume: 26 Issue: 3 Pages: 331-332
  • DOI: 10.1111/den.12224
  • Peer Reviewed / Open Access
• [Journal Article] Musosal expression of aquaporin-4 in the stomach of histamine type 2 receptor knockout mice and Helicobacter pylori-infected mice. (2014)
  • Author(s): Fukuhara, S., Matsuzaki, J., Tsugawa, H., Masaoka, T., Miyoshi, S., Mori, H., Fukushima, Y., Yasui, M., Kanai, T., Suzuki, H.
  • Journal Title: J. Gastroenterol. Hepatol. Volume: 29 Issue: S4 Pages: 53-59
  • DOI: 10.1111/jgh.12771
  • Peer Reviewed / Open Access
• [Journal Article] Changes in the first line Helicobacter pylori eradication rates using the triple therapy-a multicenter study in the Tokyo metropolitan area (Tokyo Helicobacter pylori study group) (2014)
  • Author(s): Kawai T, Takahashi S, Suzuki H, Sasaki H, Nagahara A, Asaoka D, Matsuhisa T, Masaoka T, Nishizawa T, Suzuki M, Ito M, Kurihara N, Omata F, Mizuno S, Torii A, Kawakami K, Ohkusa T, Tokunaga K, Mine T, Sakaki N.
  • Journal Title: J Gastroenterol Hepatol. Volume: Suppl 4 Issue: S4 Pages: 29-32
  • DOI: 10.1111/jgh.12796
  • Peer Reviewed / Open Access
• [Journal Article] Does bile reflux influence the progression of Barrett's esophagus to adenocarcinoma? (2014)
  • Author(s): Masaoka, T., Suzuki, H.
  • Journal Title: J. Neurogastroenterol. Motil. Volume: 20(1) Issue: 1 Pages: 124-126
  • DOI: 10.5056/jnm.2014.20.1.124
  • Peer Reviewed / Open Access
• [Journal Article] Gastrointestinal motility changes and myenteric plexus alterations in spontaneously diabetic biobreeding rats (2013)
  • Author(s): Demedts I, Masaoka T, Kindt S, De Hertogh G, Geboes K, Farre R, Vanden Berghe P, Tack J.
  • Journal Title: J Neurogastroenterol Motil. Volume: 19 Issue: 2 Pages: 161-170
  • DOI: 10.5056/jnm.2013.19.2.161
  • Peer Reviewed
• [Journal Article] Validation of octanoate breath test for measuring gastric emptying in rats (2013)
  • Author(s): Demedts I, Vanormelingen C, Van Billoen H, Vanuytsel T, Farre R, Masaoka T, Verbruggen A, Verbeke K, Vanden Berghe P, Tack J.
  • Journal Title: J Neurogastroenterol Motil. Volume: 19 Issue: 2 Pages: 171-178
  • DOI: 10.5056/jnm.2013.19.2.171
  • Peer Reviewed
• [Journal Article] Do we need to eradicate H. pylori in patients with GORD? (2013)
  • Author(s): Masaoka, T., Suzuki, H.
  • Journal Title: ueg journal Volume: 1(4) Issue: 4 Pages: 223-225
  • DOI: 10.1177/2050640613497713
  • Peer Reviewed
• [Journal Article] In functional dyspepsia, hypersensitivity to postprandial distention correlates with meal-related symptom severity (2013)
  • Author(s): Farre R, Vanheel H, Vanuytsel T, Masaoka T, Tornblom H, Simren M, Van Oudenhove L, Tack JF.
  • Journal Title: Gastroenterology Volume: 145 Issue: 3 Pages: 566-573
  • DOI: 10.1053/j.gastro.2013.05.018
  • Peer Reviewed
• [Journal Article] The relation between symptom improvement and gastric emptying in the treatment of diabetic and idiopathic gastroparesis (2013)
  • Author(s): Janssen P, Harris MS, Jones M, Masaoka T, Farre R, Tornblom H, Van Oudenhove L, Simren M, Tack J.
  • Journal Title: Am J Gastroenterol. Volume: 108 Issue: 9 Pages: 1382-1391
  • DOI: 10.1038/ajg.2013.118
• [Journal Article] Biliary Findings Assist in Predicting Enlargement of Intraductal Papillary Mucinous Neoplasms of the Pancreas (2012)
  • Author(s): Matsuzaki J, Suzuki H, Okuda S, et al.
  • Journal Title: Clininal Gastroenterology and Hepatology Volume: (印刷中) Issue: 5 Pages: 548-554
  • DOI: 10.1016/j.cgh.2012.11.027
  • Peer Reviewed
• [Presentation] 性差が胃排出能に与える影響：FD及びFGIDsの病態の基盤としての消化管運動の性差 (2016)
  • Author(s): 谷口果奈美、鈴木秀和、森英毅、清水俊志、山根剛、柏崎有紀、松崎潤太郎、正岡建洋、金井隆典
  • Organizer: 第12回日本消化管学会総会学術集会
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2016-02-27
• [Presentation] 睡眠障害と機能性ディスペプシアおよび胃排出能の関連についての検討 (2015)
  • Author(s): 山根剛、正岡 建洋、鈴木 秀和、森 英毅、松崎 潤太郎、柏崎有紀、小森貴大、清水俊志、谷口果奈美、 金井隆典
  • Organizer: 第17回日本神経消化器病学会
  • Place of Presentation: 沖縄科学技術大学院大学（沖縄県恩納村）
  • Year and Date: 2015-11-13
• [Presentation] 高解像度食道内圧測定で診断した胃食道接合部通過障害の臨床的意義 (2015)
  • Author(s): 正岡 建洋、鈴木 秀和、山根剛、松崎潤太郎、西澤俊宏、森 英毅、気賀澤 悠、 竹内 裕也、北川 雄光、金井 隆典
  • Organizer: 第17回日本神経消化器病学会
  • Place of Presentation: 沖縄科学技術大学院大学（沖縄県恩納村）
  • Year and Date: 2015-11-12
• [Presentation] H.pylori菌体由来因子(NapA)の遺伝子変異とディスペプシア症状の関連 (2015)
  • Author(s): 柏崎有紀、松崎 潤太郎、森 英毅、津川 仁、山根剛、正岡 建洋、 西澤俊宏、 金井隆典誠、 鈴木 秀和
  • Organizer: 第17回日本神経消化器病学会
  • Place of Presentation: 沖縄科学技術大学院大学（沖縄県恩納村）
  • Year and Date: 2015-11-12
• [Presentation] Comparison of characteristics of patients with duodenal tumor in the 2nd portion and those in the bulb: age- and gender-matched case-control study (2015)
  • Author(s): Ueda M., Matsuzaki J., Masaoka, T., Fukuhara S., Miyoshi S., Mori, H., Kanai, T., Sugino Y., Iwao Y., Suzuki, H.
  • Organizer: UEG Week 2015
  • Place of Presentation: バルセロナ（スペイン）
  • Year and Date: 2015-10-27
  • Int'l Joint Research
• [Presentation] シカゴ分類第3版に基づいた高解像度食道内圧測定による食道運動障害の診断 (2015)
  • Author(s): 正岡 建洋、森 英毅、気賀澤 悠、 武居 友子、竹内 裕也、北川 雄光、金井 隆典、鈴木 秀和
  • Organizer: 第69回日本食道学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2015-07-03
• [Presentation] Rifabutin含有レジメンによるH.pylori多剤耐性菌治療の検討 (2015)
  • Author(s): 森 英毅、松崎 潤太郎、正岡 建洋、津川 仁、岩崎 栄典、西澤 俊宏、上田真裕、柏崎有紀、金井 隆典、鈴木 秀和
  • Organizer: 第21回日本ヘリコバクター学会学術集会
  • Place of Presentation: ポートピアホテル（兵庫県神戸市）
  • Year and Date: 2015-06-27
• [Presentation] 京都内多施設共同調査におけるHelicobacter pylori一次・二次除菌率の経年変化 続報 (2015)
  • Author(s): 正岡建洋、鈴木秀和、西澤俊宏、小俣富美雄、伊藤愼芳、浅岡大介、水野滋章、大草敏史、川村洋、徳永健吾、佐々木仁、鳥居明、栗原直人、松久威史、鈴木雅之、永原章仁、峯徹哉、河合隆、榊信廣、高橋信一
  • Organizer: 第21回日本ヘリコバクター学会学術集会
  • Place of Presentation: ポートピアホテル（兵庫県神戸市）
  • Year and Date: 2015-06-27
• [Presentation] CD44発現に繋がるピロリ菌感染宿主細胞キャラクター (2015)
  • Author(s): 津川 仁、 柏崎有紀、森 英毅、松崎 潤太郎、 正岡 建洋、 佐藤聡、井本 正哉、 末松 誠、 鈴木 秀和
  • Organizer: 第21回日本ヘリコバクター学会学術集会
  • Place of Presentation: ポートピアホテル（兵庫県神戸市）
  • Year and Date: 2015-06-26
• [Presentation] Adiponectin Ameliorates Carcinogenic Pathway Depending on miR-221/222 in Esophageal Adenocarcinoma Cells (2015)
  • Author(s): Matsuzaki, J., Tsugawa, H., Masaoka, T., Mori, H., Watanabe, M., Kanai, T., Suzuki, H.
  • Organizer: Digestive Disease Week 2015
  • Place of Presentation: サンディエゴ（アメリカ）
  • Year and Date: 2015-05-16
  • Int'l Joint Research
• [Presentation] Smoking, a Previous History of Malignancy, and the Presence of Barrett's Esophagus As Risk Factors for Adenoma and Carcinoma of the Duodenum (2015)
  • Author(s): Matsuzaki, J., Masaoka, T., Fukuhara S., Okada S., Mori, H., Kanai, T., Sugino Y., Suzuki, H.
  • Organizer: Digestive Disease Week 2015
  • Place of Presentation: サンディエゴ（アメリカ）
  • Year and Date: 2015-05-16
  • Int'l Joint Research
• [Presentation] Overexpression of CD44v9 in Gastric Cancer Cells Confers Resistance to Trastuzumab by Inducing Antioxidant Enzymes That Inhibit Tumor Cell Death Induced by Oxidative Stress (2015)
  • Author(s): Mori H., Suzuki H., Matsuzaki, J., Tsugawa H., Okada S., Masaoka, T., Kanai, T.
  • Organizer: Digestive Disease Week 2015
  • Place of Presentation: サンディエゴ（アメリカ）
  • Year and Date: 2015-05-16
  • Int'l Joint Research
• [Presentation] 当院におけるNutCracker食道症例の検討 (2015)
  • Author(s): 正岡建洋、鈴木秀和、西澤俊宏、岩崎栄典、松崎潤太郎、森英毅、 金井隆典
  • Organizer: 第11回日本消化管学会
  • Place of Presentation: 東京、京王プラザホテル
  • Year and Date: 2015-02-13
• [Presentation] Relationship between sub-classification of functional dyspepsia and gastric emptying (2015)
  • Author(s): MasaokaT., Matsuzaki J., Mori H., Tanaka K., Ichikawa Y., Kohmoto H., Komori T., Togawa K., Mizushima I., Nishizawa T., Iwasaki E., Mizushima T., Kanai T., Suzuki H.
  • Organizer: 4th Biennial Congress of Asian Neurogastroenterology & Motility Association
  • Place of Presentation: Delhi, India
  • Year and Date: 2015-02-07
• [Presentation] 高解像度食道内圧測定で診断されたNutCracker食道症例の検討 (2014)
  • Author(s): 正岡建洋、西澤俊宏、岩崎栄典、松崎潤太郎、森英毅、金井隆典、 鈴木秀和
  • Organizer: 第16回日本神経消化器病学会
  • Place of Presentation: 東京, 学術総合センター
  • Year and Date: 2014-11-07
• [Presentation] FDの亜分類と胃排出遅延の関係の検討 (2014)
  • Author(s): 正岡建洋、松崎潤太郎、森英毅、田中健太郎、市川百合香、河本ひかり、 小森貴大、東川康嗣、水島一郎、西澤俊宏、岩崎栄典、金井隆典、鈴木秀和
  • Organizer: 第8回機能性ディスペプシア研究会
  • Place of Presentation: 東京, 学術総合センター
  • Year and Date: 2014-11-06
• [Presentation] 十二指腸粘膜防御機構と胃十二指腸領域由来症状の関連の検討 (2014)
  • Author(s): 正岡建洋、福原誠一郎、鈴木秀和
  • Organizer: JDDW 2014
  • Place of Presentation: 神戸, 神戸国際会議場
  • Year and Date: 2014-10-24
• [Presentation] Role of delayed gastric emptying in pathogenesis of Japanese FD patients (2014)
  • Author(s): Masaoka T., Fukuhara S., Suzuki H.
  • Organizer: JDDW 2014
  • Place of Presentation: 神戸, 神戸国際会議場
  • Year and Date: 2014-10-23
• [Presentation] Endoplasmic reticulum chaperone, 78 kDa glucose-regulated protein regulates neuronal nitric oxide expression. (2014)
  • Author(s): Masaoka T., Tsugawa H., Matsuzaki J., Mori H., Fukuhara S., Miyoshi S., Iwasaki E., Mizushima T., Tack J., Kanai T., Suzuki H.
  • Organizer: The 1st Federation of Neurogastroenterology and Motility Meeting
  • Place of Presentation: Guangzhou, China
  • Year and Date: 2014-09-06 – 2014-09-07
• [Presentation] 東京都多施設共同調査におけるHelicobacter pylori一次・二次除菌率の経年変化の検討 (2014)
  • Author(s): 正岡建洋、鈴木秀和、小俣富美雄、水野滋章、伊藤愼芳、川上浩平、大草敏史、徳永健吾、栗原直人、松久威史、西澤俊宏、鈴木雅之、鳥居明、浅岡大介、永原章仁、竹内義明、 森英毅、松﨑潤太郎、峯徹哉、河合隆、高橋信一、榊信廣
  • Organizer: 第20回日本ヘリコバクター学会学術集会
  • Place of Presentation: 東京, ステーションコンファレンス東京
  • Year and Date: 2014-06-28
• [Presentation] Stem cell research in Neurogastroenterology and Motility (2014)
  • Author(s): Masaoka T.
  • Organizer: 15th Recent Update of Neurogastroenterology and Motility Symposium
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2014-06-14
  • Invited
• [Presentation] 機能性ディスペプシア患者及び糖尿病患者における13C酢酸負荷呼気試験を用いた胃排出遅延の合併率の検討 (2014)
  • Author(s): 正岡建洋、鈴木秀和、福原誠一郎、松崎潤太郎、三好佐和子、森英毅、 金井隆典
  • Organizer: 第100回日本消化器病学会総会
  • Place of Presentation: 東京, 東京国際フォーラム
  • Year and Date: 2014-04-25
• [Presentation] 緑茶主成分Epigallocatechin gallateによる小胞体シャペロンGRP78抑制を介したnNOS活性化機構の検討
  • Author(s): 正岡建洋, 鈴木秀和, 津川仁, Tim Vanuystel, Jan Tack
  • Organizer: 第66回日本酸化ストレス学会学術集会
  • Place of Presentation: 名古屋
• [Presentation] FD症状を緩和する緑茶主成分Epigallocatechin gallateによる小胞体シャペロンGRP78抑制を介したnNOS活性化機構の検討
  • Author(s): 正岡建洋, 鈴木秀和, Jan Tack
  • Organizer: JDDW2013
  • Place of Presentation: 東京
• [Presentation] 小胞体シャペロンGRP78はnNOS発現を制御する
  • Author(s): 正岡建洋、津川仁、福原誠一郎、三好佐和子、森英毅、 Jan Tack、金井隆典、鈴木秀和
  • Organizer: 第15回日本神経消化器病学会
  • Place of Presentation: 島根
• [Presentation] Blatchford scoreを用いた上部消化管出血に対する緊急内視鏡検査の必要性の評価
  • Author(s): 正岡建洋、鈴木秀和、福原誠一郎、岡田佐和子、森英毅、上野浩一、 小林陽介、堀進悟、金井隆典
  • Organizer: 第96回日本消化器内視鏡学会関東地方会
  • Place of Presentation: 東京