| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
When we consider the strategy of chronotherapy, it is important to know architecture of biological clock oscillation of treatment resistant hypoxic area in cancer tissue. In this project, the effects of hypoxia to cancer clock were examined. Oxygen concentration and timing dependently hypoxic pulse phase shifted cancer clock. Magnitude of phase shift of cancer clock by hypoxic pulse was attenuated by suppression of pH reduction by addition of buffer. Hypoxic pulse increased clock genes, Per1 and Dec1, expressions which were not affected by suppression of pH reduction. From these findings, we can speculate the condition of clock oscillation in hypoxic area of cancer tissue.
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