| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
The hypothalamus is the center for body weight regulation, and controls regulating appetite and energy expenditure by integrating energy information delivered from the peripheral tissues. The hypothalamus can maintain the body weight within a certain range while young, but the hypothalamic system gradually deteriorates with aging, leading to weight gain during middle age. The disruption of the central energy homeostasis leads to metabolic syndrome and diseases, ultimately shortening healthy lifespan.
By using the genetic model of central insulin resistance, we showed that SIRT1 can ameliorate the obesity caused by insulin-resistant FoxO1 in the hypothalamus. In principle it proved the concept that SIRT1 improves the function of the central energy homeostasis center by improving insulin sensitivity.
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