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Cholinergic trigger drives synaptic plasticity for stress avoidance task

Research Project

Project/Area Number 25460314
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Environmental physiology(including physical medicine and nutritional physiology)
Research InstitutionYamaguchi University

Principal Investigator

MITSUSHIMA Dai  山口大学, 医学(系)研究科(研究院), 教授 (70264603)

Co-Investigator(Renkei-kenkyūsha) KIDA Hiroyuki  山口大学, 大学院医学系研究科, 助教 (70432739)
ISHIKAWA Junko  山口大学, 大学院医学系研究科, 助教 (30570808)
SAKIMOTO Yuya  山口大学, 大学院医学系研究科, 助教 (40634390)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywordsストレス / 学習・記憶 / AMPA受容体 / GABAA受容体 / シナプス可塑性 / パッチクランプ法 / 回避学習 / グルタミン酸 / GABA / アセチルコリン / エントロピー / 学習 / エピソード記憶
Outline of Final Research Achievements

Acute stress forms strong episodic memory, being useful to avoid similar stress in future. Learning of stressful context by the inhibitory avoidance task strengthens not only AMPA receptor-mediated excitatory synapses, but also GABAA receptor-mediated inhibitory synapses, showing wide-diversity of synaptic input after the contextual learning in rats. Learning requires the diversity of synapses, since blocking to forms diversity successfully impaired the learning. CA1 neurons showed rapid synaptic diversity within 5 min after the episode, and we observed the diversity both sides of hippocampus, in right and left hemisphare. Moreover, self-entoropy analysis of the diversity revealed the amount of information at the synapses. The total self-entropy at synapses in 400000 CA1 neurons was estimated 5.6 x 1000000 bit after the learning.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (29 results)

All 2016 2015 2014 2013 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Open Access: 6 results,  Acknowledgement Compliant: 5 results) Presentation (15 results) (of which Invited: 5 results) Remarks (5 results)

  • [Journal Article] Motor training promotes both synaptic and intrinsic plasticity of layer II/III pyramidal neurons in the primary motor cortex.2016

    • Author(s)
      Kida H, Tsuda Y, Ito N, Yamamoto Y, Owada Y, Kamiya Y, Mitsushima D.
    • Journal Title

      Cerebral Cortex

      Volume: in press Issue: 8 Pages: 3494-507

    • DOI

      10.1093/cercor/bhw134

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Astrocyte-expressed FABP7 regulates dendritic morphology and excitatory synaptic function of cortical neurons.2016

    • Author(s)
      Ebrahimi M, Yamamoto Y, Sharifi K, Kida H, Kagawa Y, Yasumoto Y, Islam A, Miyazaki H, Shimamoto C, Maekawa M, Mitsushima D, Yoshikawa T, Owada Y.
    • Journal Title

      Glia

      Volume: 64(1) Issue: 1 Pages: 48-62

    • DOI

      10.1002/glia.22902

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Stoichiometry and phosphoisotypes of hippocampal AMPA-type glutamate receptor phosphorylation.2015

    • Author(s)
      Hosokawa T, Mitsushima D, Kaneko R, Hayashi Y.
    • Journal Title

      Neuron

      Volume: 85(1) Issue: 1 Pages: 60-7

    • DOI

      10.1016/j.neuron.2014.11.026

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Contextual learning requires functional diversity at excitatory and inhibitory synapses onto CA1 pyramidal neurons.2015

    • Author(s)
      Mitsushima D.
    • Journal Title

      AIMS Neuroscience

      Volume: 2 Pages: 7-17

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Developmental trajectory of contextual learning and 24-h acetylcholine release in the hippocampus.2014

    • Author(s)
      Takase K, Sakimoto Y, Kimura F, Mitsushima D.
    • Journal Title

      Scientific Reports

      Volume: 4 Issue: 1 Pages: 3738-3738

    • DOI

      10.1038/srep03738

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] An enriched rearing environment calms adult male rat sexual activity: implication for distinct serotonergic and hormonal responses to females.2014

    • Author(s)
      Urakawa S, Mitsushima D, Shimozuru M, Sakuma Y, Kondo Y.
    • Journal Title

      PLoS ONE

      Volume: 9

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A cholinergic trigger drives learning-induced plasticity at hippocampal synapses.2013

    • Author(s)
      Mitsushima D, Sano A, Takahashi T.
    • Journal Title

      Nature Communications

      Volume: 4 Issue: 1 Pages: 2760-2760

    • DOI

      10.1038/ncomms3760

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Phasic synaptic incorporation of GluR2-lacking AMPA receptors at gonadotropin-releasing hormone neurons is involved in the generation of the luteinizing hormone surge in female rats.2013

    • Author(s)
      Tada H, Kuroki Y, Funabashi T, Kamiya Y, Goto T, Suyama K, Sano A, Mitsushima D, Etgen AM, Takahashi T.
    • Journal Title

      Neuroscience

      Volume: 248 Pages: 664-669

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of volatile anesthetics on the circadian rhythms of rat hippocampal acetylcholine release and locomotor activity.2013

    • Author(s)
      Kikuchi T, Tan H, Mihara T, Uchimoto K, Mitsushima D, Takase K, Morita S, Goto T, Andoh T, Kamiya Y.
    • Journal Title

      Neuroscience

      Volume: 237 Pages: 151-160

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Real-time change of neuronal activity in the hippocampal CA1 before, during, and after the exposure to emotional episodes: spontaneous high frequent firing and following ripple diversity2016

    • Author(s)
      Ishikawa J, Mitsushima D.
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      北海道札幌市札幌コンベンションセンター
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Rapid synaptic plasticity within 5 min: experienced episode increases diversity of excitatory and inhibitory synapses in the hippocampal CA12016

    • Author(s)
      Sakimoto Y, Mitsushima D.
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      北海道札幌市札幌コンベンションセンター
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Motor training promotes both synaptic and intrinsic plasticity of layer II/III neurons in the primary motor cortex.2016

    • Author(s)
      Kida H, Tsuda Y, Yamamoto Y, Ito N, Owada Y, Mitsushima D.
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      北海道札幌市札幌コンベンションセンター
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Real-time change of neural activity in the hippocampal CA1 and medial prefrontal cortex before, during, and after the exposure to a specific episode2015

    • Author(s)
      Ishikawa J, Mitsushima D.
    • Organizer
      日本生理学会
    • Place of Presentation
      神戸市(神戸国際会議場・展示場)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] Learning-dependent synaptic plasticity at CA1 synapses: laterality and a possible location of contextual memory in the hippocampus.2014

    • Author(s)
      Mizuno J, Sakimoto Y, Kida H, Ono Y, Kamiya Y, Mitsushima D.
    • Organizer
      北米神経科学大会
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] Learning-dependent synaptic diversity in hippocampal CA1 neurons: encoding of context but not retrieval induces rapid plasticity at excitatory and inhibitory synapses.2014

    • Author(s)
      Sakimoto Y, Mitsushima D.
    • Organizer
      北米神経科学大会
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 海馬CA1シナプスの多様化とエピソード記憶のメカニズム2014

    • Author(s)
      美津島 大
    • Organizer
      海馬と高次脳機能学会
    • Place of Presentation
      金沢市(金沢湯涌創作の森)
    • Year and Date
      2014-10-11 – 2014-10-12
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Learning-dependent synaptic plasticity at CA1 synapses: laterality and a possible location of contextual memory in the hippocampus2014

    • Author(s)
      Mizuno J, Sakimoto Y, Kida H, Ono Y, Kamiya Y, Mitsushima D.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Motor training changes the properties of layers II/III neurons in the primary motor cortex and glutamatergic synaptic plasticity2014

    • Author(s)
      Kida H, Tsuda Y, Yamamoto Y, Owada Y, Mitsushima D.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Learning-dependent synaptic diversity in hippocampal CA1 neurons: encoding of context but not retrieval induces rapid plasticity at excitatory and inhibitory synapses2014

    • Author(s)
      Sakimoto Y, Mitsushima D.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] 海馬CA1シナプスの多様化とエピソード記憶のメカニズム2014

    • Author(s)
      美津島 大
    • Organizer
      海馬と高次脳機能学会
    • Place of Presentation
      金沢市(湯涌創作の森 交流研修棟)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 海馬シナプスの多様化と脳内への記銘メカニズム2014

    • Author(s)
      美津島 大
    • Organizer
      時間学セミナー
    • Place of Presentation
      宇部市(山口大学医学部 霜仁会館)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] A possible location of contextual memory: CA1 subfield and laterality of learning-dependent synaptic delivery of AMPA receptors2013

    • Author(s)
      Mizuno J, Mitsushima D.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego, CA, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] エピソード記憶のメカニズム:アセチルコリンと海馬シナプス可塑性2013

    • Author(s)
      美津島 大
    • Organizer
      山口県医師会生涯研究セミナー
    • Place of Presentation
      山口市(山口県総合保健会館 多目的ホール)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 海馬アセチルコリンが誘起する、シナプス可塑性の多様化と記憶形成2013

    • Author(s)
      美津島 大
    • Organizer
      山口県Neuroscience研究会
    • Place of Presentation
      宇部市(山口大学医学部 霜仁会館)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Remarks] 日本生理学会サイエンストピックス

    • URL

      http://physiology.jp/exec/page/stopics88/

    • Related Report
      2013 Research-status Report
  • [Remarks] The Physiological Society of JAPAN

    • URL

      http://int.physiology.jp/en/4949/

    • Related Report
      2013 Research-status Report
  • [Remarks] 日本神経科学学会 神経科学トピックス

    • URL

      http://www.jnss.org/131206-01/

    • Related Report
      2013 Research-status Report
  • [Remarks] 脳の海馬内で起こる学習のメカニズムを解明、認知症の新薬開発に期待

    • URL

      http://www.yamaguchi-u.ac.jp/topics/2013/_3105.html

    • Related Report
      2013 Research-status Report
  • [Remarks] 山口大 海馬内で起こる学習メカニズムを解明

    • URL

      http://www.qlifepro.com/news/20140109/learning-mechanism-occurs-in-the-hippocampus-expect-dementia-drug-development.html

    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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