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Molecular mechanisms of obesity- behavoral changes

Research Project

Project/Area Number 25460317
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Environmental physiology(including physical medicine and nutritional physiology)
Research InstitutionJichi Medical University (2014-2016)
Toho University (2013)

Principal Investigator

Takase Kenkichi  自治医科大学, 医学部, 教授 (80381474)

Co-Investigator(Kenkyū-buntansha) 黒田 優  東邦大学, 医学部, 教授 (10170135)
小田 哲子  東邦大学, 医学部, 講師 (90224237)
船戸 弘正  東邦大学, 医学部, 准教授 (90363118)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords肥満 / 行動 / MCH / HDAC / メラニン凝集ホルモン / ヒストン脱アセチル化酵素
Outline of Final Research Achievements

Expressions of the HDAC family (HDAC 1 to 11) were examined in various brain regions and these results were published as a paper (Takase et al., 2013). In the process, the data on HDAC expressions of obese mice were accumulated. Furthermore, behavioral changes of mice deficient in MCH were quantitatively analyzed using statistical methods and these results were also published as a paper (Takase et al., 2014). We also quantitatively analyzed behavioral changes of obese mice and published there results as a paper (Takase et al., 2016). From the comparison of these data, we were able to obtain results supporting the validity of our research hypothesis. In addition, due to changes in the institution to which the applicant belongs, situations in which progress has been slightly delayed have also been improved. We are ready for comprehensive behavioral analysis of mice that manipulated HDAC expression and the analysis of gene expression changes in them.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (12 results)

All 2016 2015 2014 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Acknowledgement Compliant: 3 results,  Open Access: 2 results) Presentation (5 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Remarks (3 results)

  • [Journal Article] High-fat diet feeding alters olfactory-, social-, and reward-related behaviors of mice independent of obesity.2016

    • Author(s)
      Takase K, Tsuneoka Y, Oda S, Kuroda M, Funato H
    • Journal Title

      Obesity

      Volume: 4 Issue: 4 Pages: 886-894

    • DOI

      10.1002/oby.21441

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Meta-analysis of melanin-concentrating hormone signaling-deficient mice on behavioral and metabolic phenotypes2014

    • Author(s)
      Kenkichi Takase, Kenichi Kikuchi, Yousuke Tsuneoka, Satoko Oda, Masaru Kuroda, Hiromasa Funato
    • Journal Title

      PLoS One

      Volume: 9 Issue: 6 Pages: e99961-e99961

    • DOI

      10.1371/journal.pone.0099961

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Developmental trajectory of contextual learning and 24-h acetylcholine release in the hippocampus.2014

    • Author(s)
      Takase K, Sakimoto Y, Kimura F, Mitsushima D.
    • Journal Title

      Scientific Reports

      Volume: 4 Issue: 1 Pages: 3738-3738

    • DOI

      10.1038/srep03738

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A subset of thalamocortical projections to the retrosplenial cortex possesses two vesicular glutamate transporter isoforms, VGluT1 and VGluT2, in axon terminals as well as somata.2014

    • Author(s)
      Satoko Oda, Hiromasa Funato, Fumi Sato, Satomi Adachi-Akahane, Masanori Ito, Kenkichi Takase, Masaru Kuroda
    • Journal Title

      Journal of Comparative Neurology

      Volume: 522 Issue: 9 Pages: 2089-2106

    • DOI

      10.1002/cne.23519

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Meta-analysis of genetically modified mice on behavioral and biological phenotypes2016

    • Author(s)
      Takase K, Kikuchi K, Funato H
    • Organizer
      31st International Congress of Psychology (ICP2016)
    • Place of Presentation
      PACIFICO Yokohama, Yokohama, Japan
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] High-fat diet feeding alters social behaviors and sensorimotor system of mice independent of obesity.2015

    • Author(s)
      Funato H, Takase K, Oda S, Tsuneoka Y, Kuroda M
    • Organizer
      Keystone symposia
    • Place of Presentation
      Westin Miyako Kyoto (Kyoto)
    • Year and Date
      2015-10-26
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Statistical inference of neural circuits responsible for behavioral parameters of mice

    • Author(s)
      Takase K, Kikuchi K, Oda S, Kuroda M, Funato H
    • Organizer
      日本神経科学学会主催 第36回日本神経科学大会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 次世代の行動評定法の開発を目指して

    • Author(s)
      高瀬 堅吉
    • Organizer
      日本動物心理学会第73回大会
    • Place of Presentation
      筑波大学(茨城県つくば市)
    • Related Report
      2013 Research-status Report
  • [Presentation] これからの教育心理学を考える‐動物実験、生物学的指標とどのように付き合うのか?‐

    • Author(s)
      高瀬 堅吉
    • Organizer
      日本心理学会第77回大会
    • Place of Presentation
      札幌コンベンションセンター・札幌市産業振興センター(北海道札幌市)
    • Related Report
      2013 Research-status Report
  • [Remarks] 自治医科大学医学部心理学研究室(高瀬ラボ)

    • URL

      http://www.jichi.ac.jp/psychology/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 自治医科大学医学部心理学研究室

    • URL

      http://www.jichi.ac.jp/psychology/index.html

    • Related Report
      2015 Research-status Report
  • [Remarks] 自治医科大学 医学部 心理学研究室(高瀬ラボ)

    • URL

      http://www.jichi.ac.jp/psychology/index.html

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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