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Neural mechanism regulating body weight and glucose metabolism via orexin receptors

Research Project

Project/Area Number 25460318
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Environmental physiology(including physical medicine and nutritional physiology)
Research InstitutionToho University

Principal Investigator

FUNATO Hiromasa  東邦大学, 医学部, 准教授 (90363118)

Co-Investigator(Kenkyū-buntansha) TAKASE Kenkichi  自治医科大学, 医学部, 教授 (80381474)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords体重制御 / 神経ペプチド / 糖代謝 / 機能神経解剖学 / 肥満 / 摂食
Outline of Final Research Achievements

We examined the body weight regulation via hypothalamic neuropeptides. We showed the differential roles of orexin receptors in energy metabolism. Orexin receptor signalings enhance mTORC1 singaling. Orexin-overexpression mice fed with a high-fat diet showed stronger mTORC1 signaling in their brains. Meta-analysis revealed that MCH-signaling-deficient mice suppress body weight gain due to increased energy expenditure.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (21 results)

All 2016 2015 2014 2013 Other

All Journal Article (7 results) (of which Peer Reviewed: 6 results,  Acknowledgement Compliant: 3 results,  Open Access: 2 results) Presentation (14 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results)

  • [Journal Article] High-fat diet feeding alters olfactory-, social-, and reward-related behaviors of mice independent of obesity.2016

    • Author(s)
      Takase K, Tsuneoka Y, Oda S, Kuroda M, Funato H
    • Journal Title

      Obesity

      Volume: 4 Issue: 4 Pages: 886-894

    • DOI

      10.1002/oby.21441

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Sleep as a biological problem: an overview of frontiers in sleep research2016

    • Author(s)
      Kanda T, Tsujino N, Kuramoto E, Koyama Y, Susaki EA, Chikahisa S, Funato H
    • Journal Title

      J Physiol Sci

      Volume: 66 Issue: 1 Pages: 1-13

    • DOI

      10.1007/s12576-015-0414-3

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 眠気の正体を求めて ―フォワード・ジェネティクスによる睡眠覚醒制御機構の解明―2015

    • Author(s)
      船戸弘正
    • Journal Title

      実験医学

      Volume: 33 Pages: 2057-2062

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Orexin/Hypocretin Activates mTOR Complex 1 (mTORC1) via an Erk/Akt-independent and Calcium-stimulated Lysosome v-ATPase Pathway2014

    • Author(s)
      Zhiqiang Wang, Shimeng Liu, Miyo Kakizaki, Yuuki Hirose, Yukiko Ishikawa, Hiromasa Funato, Masashi Yanagisawa, Yonghao Yu,Qinghua Liu
    • Journal Title

      Journal of Biological Chemistry

      Volume: 289 Issue: 46 Pages: 31950-31959

    • DOI

      10.1074/jbc.m114.600015

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Meta-analysis of melanin-concentrating hormone signaling-deficient mice on behavioral and metabolic phenotypes2014

    • Author(s)
      Kenkichi Takase, Kenichi Kikuchi, Yousuke Tsuneoka, Satoko Oda, Masaru Kuroda, Hiromasa Funato
    • Journal Title

      PLoS One

      Volume: 9 Issue: 6 Pages: e99961-e99961

    • DOI

      10.1371/journal.pone.0099961

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A subset of thalamocortical projections to the retrosplenial cortex possesses two vesicular glutamate transporter isoforms, VGluT1 and VGluT2, in axon terminals as well as somata.2014

    • Author(s)
      Satoko Oda, Hiromasa Funato, Fumi Sato, Satomi Adachi-Akahane, Masanori Ito, Kenkichi Takase, Masaru Kuroda
    • Journal Title

      Journal of Comparative Neurology

      Volume: 522 Issue: 9 Pages: 2089-2106

    • DOI

      10.1002/cne.23519

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Monoaminergic and neuropeptidergic neurons have distinct expression profiles of histone deacetylases2013

    • Author(s)
      Kenkichi Takase, Satoko Oda, Masaru Kuroda, Hiromasa Funato
    • Journal Title

      PLoS One

      Volume: 8 Issue: 3 Pages: e58473-e58473

    • DOI

      10.1371/journal.pone.0058473

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Identification of Mc4r mutation through obesity screening of ENU-mutagenized mice2016

    • Author(s)
      Mohammad Sarowar Hossain, Fuyuki Asano, Tomoyuki Fujiyama, Chika Miyoshi, Makito Sato, Aya Ikkyu, Satomi Kanno, Noriko Hotta, Miyo Kakizaki, Ikuo Miura, Hideki Kaneda, Tomohiro Suzuki, Shigeharu Wakana, Hiromasa Funato, Masashi Yanagisawa
    • Organizer
      第121回日本解剖学会学術集会
    • Place of Presentation
      ビッグパレットふくしま(福島県郡山市)
    • Year and Date
      2016-03-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] ランダム点突然変異マウスの肥満スクリーニングによるSim1遺伝子変異の同定2016

    • Author(s)
      浅野冬樹 Mohammad Sarowar Hossain 藤山知之 三好千香 佐藤牧人 一久綾 管野里美 堀田範子 柿崎美代 三浦郁生 金田秀貴 鈴木智広 若菜茂晴 船戸弘正 柳沢正史
    • Organizer
      第121回日本解剖学会学術集会
    • Place of Presentation
      ビッグパレットふくしま(福島県郡山市)
    • Year and Date
      2016-03-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] 前頭前皮質におけるムスカリン受容体M1の興奮性および抑制性細胞における局在分布の比較2016

    • Author(s)
      小田哲子、船戸弘正、恒岡洋右、吉田さちね、黒田 優
    • Organizer
      第121回日本解剖学会学術集会
    • Place of Presentation
      ビッグパレットふくしま(福島県郡山市)
    • Year and Date
      2016-03-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] 生得的社会行動を制御する内側視索前野の機能解剖学的解析2016

    • Author(s)
      恒岡洋右, 吉田さちね, 小田哲子, 黒田優, 船戸弘正
    • Organizer
      第121回日本解剖学会学術集会
    • Place of Presentation
      ビッグパレットふくしま(福島県郡山市)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] High-fat diet feeding alters social behaviors and sensorimotor system of mice independent of obesity2015

    • Author(s)
      Hiromasa Funato, Kenkichi Takase, Satoko Oda, Yousuke Tsuneoka, Masaru Kuroda
    • Organizer
      Keystone Symposia Conference "Diabetes: New Insights into Molecular Mechanisms and Therapeutic Strategies"
    • Place of Presentation
      ウェスティン都ホテル(京都府京都市)
    • Year and Date
      2015-10-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] オレキシンによる体重制御機構2015

    • Author(s)
      船戸弘正
    • Organizer
      第22回 日本行動神経内分泌研究会
    • Place of Presentation
      神戸大学(兵庫県神戸市)
    • Year and Date
      2015-03-24
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Newly-identified sexually dimorphic gene expressions in the mouse medial preoptic area of hypothalamus.2015

    • Author(s)
      Yousuke Tsuneoka, Kenkichi Takase, Satoko Oda, Masaru Kuroda, Hiromasa Funato
    • Organizer
      第119回日本解剖学会・第92回生理学会合同大会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] Forward genetic approach to identify novel genes regulating sleep/wakefulness behavior2015

    • Author(s)
      Hiromasa Funato
    • Organizer
      第119回日本解剖学会・第92回生理学会合同大会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] Identification of a single nucleotide substitution specific to the Sleepy mutant mouse pedigree by linkage analysis and whole exome sequencing2014

    • Author(s)
      Hiromasa Funato, Chika Miyoshi, Makito Sato, Aya Ikkyu, Noriko Hotta, Miyo Kakizaki, Satomi Kanno, Kanako Harano, Fuyuki Asano, Tomoyuki Fujiyama, Tomohiro Suzuki, Shigeraru Wakana, Masashi Yanagisawa
    • Organizer
      Neuroscience 2014
    • Place of Presentation
      米国Washington DC
    • Year and Date
      2014-11-17
    • Related Report
      2014 Research-status Report
  • [Presentation] Identification of a single nucleotide substitution specific to the Sleepy mutant mouse pedigree by linkage analysis and whole exome sequencing2014

    • Author(s)
      船戸弘正 三好千香 佐藤牧人 一久綾 堀田範子 柿崎美代 管野里美 原野加奈子 浅野冬樹 藤山知之 鈴木智広 若菜茂晴 柳沢正史
    • Organizer
      第37回日本神経科学学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-09-12
    • Related Report
      2014 Research-status Report
  • [Presentation] A subset of thalamocortical projections to the retrosplenial cortex possesses both VGluT1 and VGluT2

    • Author(s)
      Satoko Oda, Hiromasa Funato, Fumi Sato, Satomi Adachi-Akahane, Masanori Ito, Kenkichi Takase, Masaru Kuroda
    • Organizer
      第119回日本解剖学会学術集会
    • Place of Presentation
      自治医科大学(栃木県下野市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 摂食関連神経ペプチド産生細胞ネットワークにおけるヒストン脱アセチル化酵素の発現

    • Author(s)
      恒岡洋右 高瀬堅吉 黒田優 船戸弘正
    • Organizer
      第119回日本解剖学会学術集会
    • Place of Presentation
      自治医科大学(栃木県下野市)
    • Related Report
      2013 Research-status Report
  • [Presentation] Forward genetic analysis of ENU mutagenized mice identified multiple pedigrees exhibiting heritable sleep/wake abnormalities.

    • Author(s)
      Hiromasa Funato, Chika Miyoshi, Makito Sato, Aya Ikkyu, Mariko Isshiki, Yuto Goto, Kanako Harano, Satomi Kanno, Miyo Kakizaki, Sayuki Kiatagawa, Sachiko Tomita, Tomohiro Suzuki, Shigeharu Wakana, Masashi Yanagisawa
    • Organizer
      Neuro2013
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Related Report
      2013 Research-status Report
  • [Presentation] Statistical inference of neural circuits responsible for behavioral parameters of mice

    • Author(s)
      Kenkichi Takase, Kenichi Kikuchi, Satoko Oda, Masaru Kuroda, Hiromasa Funato
    • Organizer
      Neuro2013
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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