Neural mechanism regulating body weight and glucose metabolism via orexin receptors
| Project/Area Number |
25460318
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Toho University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKASE Kenkichi 自治医科大学, 医学部, 教授 (80381474)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 体重制御 / 神経ペプチド / 糖代謝 / 機能神経解剖学 / 肥満 / 摂食 |
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| Outline of Final Research Achievements |
We examined the body weight regulation via hypothalamic neuropeptides. We showed the differential roles of orexin receptors in energy metabolism. Orexin receptor signalings enhance mTORC1 singaling. Orexin-overexpression mice fed with a high-fat diet showed stronger mTORC1 signaling in their brains. Meta-analysis revealed that MCH-signaling-deficient mice suppress body weight gain due to increased energy expenditure.
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Report
(4 results)
Research Products
(21 results)
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[Presentation] Identification of Mc4r mutation through obesity screening of ENU-mutagenized mice2016
Author(s)
Mohammad Sarowar Hossain, Fuyuki Asano, Tomoyuki Fujiyama, Chika Miyoshi, Makito Sato, Aya Ikkyu, Satomi Kanno, Noriko Hotta, Miyo Kakizaki, Ikuo Miura, Hideki Kaneda, Tomohiro Suzuki, Shigeharu Wakana, Hiromasa Funato, Masashi Yanagisawa
Organizer
第121回日本解剖学会学術集会
Place of Presentation
ビッグパレットふくしま（福島県郡山市）
Year and Date
2016-03-29
Related Report
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[Presentation] Identification of a single nucleotide substitution specific to the Sleepy mutant mouse pedigree by linkage analysis and whole exome sequencing2014
Author(s)
Hiromasa Funato, Chika Miyoshi, Makito Sato, Aya Ikkyu, Noriko Hotta, Miyo Kakizaki, Satomi Kanno, Kanako Harano, Fuyuki Asano, Tomoyuki Fujiyama, Tomohiro Suzuki, Shigeraru Wakana, Masashi Yanagisawa
Organizer
Neuroscience 2014
Place of Presentation
米国Washington DC
Year and Date
2014-11-17
Related Report
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[Presentation] Forward genetic analysis of ENU mutagenized mice identified multiple pedigrees exhibiting heritable sleep/wake abnormalities.
Author(s)
Hiromasa Funato, Chika Miyoshi, Makito Sato, Aya Ikkyu, Mariko Isshiki, Yuto Goto, Kanako Harano, Satomi Kanno, Miyo Kakizaki, Sayuki Kiatagawa, Sachiko Tomita, Tomohiro Suzuki, Shigeharu Wakana, Masashi Yanagisawa
Organizer
Neuro2013
Place of Presentation
国立京都国際会館（京都府京都市）
Related Report
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