| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
To determine regulatory mechanisms of estrogen receptor gene expression, alternative promoter usage and alternative splicing profiles of the estrogen receptor genes were examined. We identified modular structures of the estrogen receptor genes and several splice variants encoding N- and C-terminally-truncated estrogen receptor proteins. Some C-terminally-truncated estrogen receptor variants exhibited constitutive transcriptional transactivation in transfected cells. Ligand-independent transcriptional transactivation by steroid hormone receptors is deduced to be one of the candidate causes of malignant development of hormone-sensitive tumors. Therefore, our results may provide key mechanistic information explaining the cause of hormone-independent cell overgrowth in estrogen-sensitive tumors.
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