| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Sex differences of the brain would be important for the gender identity, however, the mechanism of the sexual differentiation of the brain remains largely unknown. The sexually dimorphic nucleus of the preoptic area (SDN-POA) is thought to contribute to the gender identity. In this study, we examined the sexual differentiation of the SDN-POA using the organotypic brain slice cultures and time-lapse imaging in vitro to test the hypothesis that neural migration regulated by estrogen is critical for the sexual differentiation of the SDN-POA. The scattering neural migration by estrogen was observed in the masculinization of the SDN-POA. This estrogen induced scattering migration was mediated through the estrogen receptor alpha/Rac1/cofilin/actin pathway. These results suggest that scattering neural migration by estrogen is critical role for the masculinization of the SDN-POA.
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