Sexual differentiation of the sexually dimorphic nucleus of the preoptic area and the bed nucleus of the stria terminalis responsible for the gender identity.
| Project/Area Number |
25460320
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
塚原 伸治 埼玉大学, 理工学研究科, 准教授 (90318824)
佐久間 康夫 東京医療学院大学, 保健医療学部, 教授 (70094307)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 脳の性差 / 性差形成機構 / エストロゲン / 性別違和 / 視索前野性的二型核 / 性分化機構 / 性差 / 分界条床核 |
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| Outline of Final Research Achievements |
Sex differences of the brain would be important for the gender identity, however, the mechanism of the sexual differentiation of the brain remains largely unknown. The sexually dimorphic nucleus of the preoptic area (SDN-POA) is thought to contribute to the gender identity. In this study, we examined the sexual differentiation of the SDN-POA using the organotypic brain slice cultures and time-lapse imaging in vitro to test the hypothesis that neural migration regulated by estrogen is critical for the sexual differentiation of the SDN-POA. The scattering neural migration by estrogen was observed in the masculinization of the SDN-POA. This estrogen induced scattering migration was mediated through the estrogen receptor alpha/Rac1/cofilin/actin pathway. These results suggest that scattering neural migration by estrogen is critical role for the masculinization of the SDN-POA.
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Report
(5 results)
Research Products
(6 results)
