| Project/Area Number |
25460322
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Osaka Institute of Technology |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
渡部 紀久子 甲子園大学, 栄養学部, 教授 (90211672)
山形 要人 公益財団法人東京都医学総合研究所, 脳発達・神経再生研究分野, プロジェクトリーダー (20263262)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 脳出血 / 発熱 / プロスタグランジン / シクロオキシゲナーゼ / 血小板 / シクロオキシゲナーゼー１ / 体温調節中枢 / 血管内皮 / COX-1 / mPGES-1 / くも膜 / COX-2 |
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| Outline of Final Research Achievements |
The purpose of this study is to clarify the molecular and cellular mechanism of fever following brain hemorrhage. Using a mouse model of brain hemorrhage fever, we confirmed that prostaglandin E2 (PGE2) was increased in the hemorrhaged region. This PGE2 production was dependent on cyclooxygenase-1 (COX-1). Aggregated platelets expressed high levels of COX-1 in the hemorrhaged region suggesting that platelets are involved in PGE2 production and fever following brain hemorrhage. In the downstream of COX-1, microsomal PGE synthase-1 (mPGES-1) played the major role in the production of PGE2. However, in some cases, fever was evident in the absence of PGE2 production. These results suggest that fever following brain hemorrhage involves PGE2-dependent and PGE2-independent mechanisms, the former being mediated by COX-1 and mPGES-1 pathway and the latter being due to the functional impairment of the thermoregulatory center.
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