| Project/Area Number |
25460323
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
|
|---|
| Research Institution | Kurashiki University of Science and the Arts (2015-2016)
Kansai Medical University (2013-2014) |
|---|
Principal Investigator |
Okada Masayoshi 倉敷芸術科学大学, 生命科学部, 教授 (40334677)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
松田 博子 関西医科大学, 医学部, 教授 (10181736)
ROMERO GUSTAVO 関西医科大学, 医学部, 研究員 (30572820)
|
|---|
| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
|
|---|
| Keywords | K+ チャネル / TREK / うつ / 不安 / K+ channel / ストレス / TREK-1 / 不安様行動 / うつ様行動 / c-fos / パッチクランプ / イオンチャネル / 視床室傍核 / 抑制性シナプス後電流 |
|---|
| Outline of Final Research Achievements |
We have screened botanical compounds and found a novel 2-pore-domain type K+ channel activator with patch-clamp recordings. This compound showed both anxiolytic and antidepressive effects in the mouse behavior tests. The compound had no effect on anti-c-fos immunoreactivity in the brain of nontreated-mouse but suppressed a stress-induced increase in the anti-c-fos immunoreactivity in a nucleus. This site of action was different from those of current anxiolytic or antidepressant, suggesting a novel mechanism this compound.
We also revealed the involvement of intracellular transport in the run-up of TREK-1 channel current.
|
