Neuromodulatory effects of feeding signasl in GLP-1 releasing neurons of the brainstem
| Project/Area Number |
25460336
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Hokkaido University (2014-2015)
Saga University (2013) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 摂食調節 / 内分泌 / 中枢神経 / 糖尿病 / 代謝学 / 肥満 |
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| Outline of Final Research Achievements |
Glucagon-like peptide-1 (GLP-1) is one of gut hormones act as a satiety signal in the brain. However, circulating GLP-1 is unlikely to reach receptors in the brain because of its rapid metabolization in the blood. GLP-1 is also produced in a small population of cells in the brainstem. We propose that the GLP-1 releasing neurons play an important role in satiety and have started to characterize the relationship between satiety molecules (e.g. orexin, serotonin, and glucose), and the GLP-1 releasing neurons in the brainstem.
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Report
(4 results)
Research Products
(4 results)
