| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
Clathrin heavy chains (CHCs) are known as essential molecules for intracellular vesicular transport. Recently, some reports revealed that these play important roles in mitosis and transfer. In this study, we showed that inhibition of mitochondrial respiration increased CHC17, one of CHC isoforms, in nuclear fraction by using biochemical analysis. However, immunohistorogical analysis did not show this phenomenon. Through these experiments, we revealed the biochemical characteristics of CHC22, another isoform of CHC. By using this, we success to separate CHC17 and CHC22.
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