| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Outline of Final Research Achievements |
Myogenic tone have been known to plays important role for regulation of the peripheral artery resistance and blood stream in heart, kidney and brain, but the molecular mechanism still unclear. To claryfy the role of NCX1 expression and localization in myogenic tone, we generated smooth muscle spesific NCX1-EGFP transgenic mice. We found that myogenic responses were attenuated in PIP5K-beta knockout mice. Furthermore, gene expression level of NCX1 was decreased in PIP5K-beta knockout mice, compared with wild-type mice, suggesting that regulation of NCX1 activity by PIP2 is involved in myogenic tone.
|
