Research Project
Grant-in-Aid for Scientific Research (C)
We identified eight candidate kinases whose down-regulation protected against Fas ligand-induced apoptosis. At first, we established knockout cells lacking each kinase, and examined the requirement for apoptosis and their functions in apoptosis. Notably we have demonstrated that STK11participates in the control of death receptor-mediated signals through phosphorylation of CYLD, a deubiquitinating enzyme that regulates both pro- and anti-apoptotic activities of the death receptors via targeting RIPK1. These results reveal STK11 as a novel modulator of pro- and anti-apoptotic signals emanating from the death receptors.
All 2015 2014 Other
All Int'l Joint Research (2 results) Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (8 results) (of which Invited: 2 results)
J. Biol. Chem
Volume: 290 Pages: 56-64
