| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Outline of Final Research Achievements |
The ubiquitin editing enzyme A20 is composed of an N-terminal OTU domain and 7 C-terminal zinc finger motifs (ZnFs). A20 functions as a de-ubiquitinating enzyme through the OTU domain and as an ubiquitin E3 ligase through the 4th ZnF. A20 suppresses activation of the transcription factor NF-κB in an enzymatic activity-dependent manner. In this study, A20 was found to directly bind to another ubiquitin E3 ligase cIAP1 through the 7th ZnF (ZnF7) and induce activation of NF-κB and suppression of apoptosis by controlling cIAP1. Because ZnF7 is frequently mutated in B-cell lymphoma, defects in control of cIAP1 by A20 may be involved in progression of this disease.
|
