The mechanisms of A20-mediated control of cIAP1 and its involvement in diseases.
Project/Area Number |
25460356
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General medical chemistry
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Research Institution | Chiba University |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | シグナル伝達 / ユビキチン / アポトーシス / TNF |
Outline of Final Research Achievements |
The ubiquitin editing enzyme A20 is composed of an N-terminal OTU domain and 7 C-terminal zinc finger motifs (ZnFs). A20 functions as a de-ubiquitinating enzyme through the OTU domain and as an ubiquitin E3 ligase through the 4th ZnF. A20 suppresses activation of the transcription factor NF-κB in an enzymatic activity-dependent manner. In this study, A20 was found to directly bind to another ubiquitin E3 ligase cIAP1 through the 7th ZnF (ZnF7) and induce activation of NF-κB and suppression of apoptosis by controlling cIAP1. Because ZnF7 is frequently mutated in B-cell lymphoma, defects in control of cIAP1 by A20 may be involved in progression of this disease.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] c-Abl induces stabilization of histone deacetylase 1 (HDAC1) in a kinase activity-dependent manner.2015
Author(s)
Kazumasa Aoyama, Noritaka Yamaguchi, Ryuzaboro Yuki, Mariko Morii, Sho Kubota, Kensuke Hirata, Kohei Abe, Takuya Honda, Takahisa Kuga, Yuuki Hashimoto, Takeshi Tomonaga, and Naoto Yamaguchi
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Journal Title
Cell Biology International
Volume: 39
Issue: 4
Pages: 446-456
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Overexpression of Zinc-finger protein 777 (ZNF777) inhibits proliferation at low cell density through down-regulation of FAM129A.2015
Author(s)
Yuki, R., Aoyama, K., Kubota, S., Yamaguchi, N.-t., Kubota, S.-i., Hasegawa, H., Morii, M., Huang, X., Liu, K., Williams, R., Fukuda, M.N., and Yamaguchi, N.
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Journal Title
J. Cell. Biochem.
Volume: in press
Issue: 6
Pages: 954-968
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Tropomodulin 1 expression driven by NF-kB enhances breast cancer growth.2015
Author(s)
Ito-Kureha, T., Koshikawa, N., Yamamoto, M., Semba, K., Yamaguchi, N., Yamamoto, T., Seiki, M. and Inoue, J.
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Journal Title
Cancer Res
Volume: 75
Issue: 1
Pages: 62-72
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Src family kinases promote silencing of ATR-Chk1 signaling in termination of DNA damage2014
Author(s)
Yasunori Fukumoto, Mariko Morii, Takahito Miura, Sho Kubota, Kenichi Ishibashi, Takuya Honda, Aya Okamoto, Noritaka Yamaguchi, Atsushi Iwama, Yuji Nakayama, Naoto Yamaguchi
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Journal Title
The Journal of Biological Chemistry
Volume: in press
Issue: 18
Pages: 12313-12329
DOI
Related Report
Peer Reviewed
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[Journal Article] v-Src inhibits the interaction between Rad17 and Rad9 and induces replication fork collapse.2014
Author(s)
Fukumoto, Y., Miura, T., Morii, M., Kubota, S., Honda, T., Kubota, S.-i., Morinaga, T., Yamaguchi, N.-t., Nakayama, Y., and Yamaguchi, N.
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Journal Title
Biochem. Biophys. Res. Commun.
Volume: 450
Issue: 1
Pages: 885-890
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Lyn tyrosine kinase promotes silencing of ATM-dependent checkpoint signaling during recovery from DNA double-strand breaks.2014
Author(s)
Fukumoto, Y., Kuki, K., Morii, M., Miura, T., Honda, T., Ishibashi, K., Hasegawa, H., Kubota, S., Ide, Y., Yamaguchi, N.-t., Nakayama, Y., and Yamaguchi, N.
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Journal Title
Biochem. Biophys. Res. Commun.
Volume: 452
Issue: 3
Pages: 542-547
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Formation of long and winding nuclear F-actin bundles by nuclear c-Abl tyrosine kinase.2013
Author(s)
Aoyama K., Yuki R., Horiike Y., Kubota S., Yamaguchi N., Morii M., Ishibashi K., Nakayama Y., Kuga T., Hashimoto Y., Tomonaga T, and Yamaguchi N.
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Journal Title
Exp Cell Res
Volume: 319
Issue: 20
Pages: 3251-68
DOI
Related Report
Peer Reviewed
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[Journal Article] Phosphorylation of KRAB-associated Protein 1 (KAP1) at Tyr-449, Tyr-458, and Tyr-517 by Nuclear Tyrosine Kinases Inhibits the Association of KAP1 and Heterochromatin Protein 1alpha (HP1alpha) with Heterochromatin.2013
Author(s)
Kubota, S., Fukumoto, Y., Aoyama, K., Ishibashi, K., Yuki, R., Morinaga, T., Honda, T., Yamaguchi, N., Hashimoto, Y., Kuga, T., Tomonaga T, and Yamaguchi, N.
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Journal Title
J Biol Chem
Volume: 288,
Issue: 24
Pages: 17871-17883
DOI
Related Report
Peer Reviewed
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[Presentation] Search for a tyrosine-phosphorylated protein involved in Src-mediated antiapoptosis.2016
Author(s)
Morii, M., Kubota, S., Honda, T., Aoyama, K., Yuki, R., Kometani, S., Yamaguchi, N.-t.,and Yamaguchi, N.
Organizer
Gordon Research Seminar on DNA Damage, Mutation and Cancer
Place of Presentation
Ventura, USA
Year and Date
2016-03-13
Related Report
Int'l Joint Research
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[Presentation] Involvement of tyrosine phosphorylation of the pioneer transcription factor FoxA1 in the estrogen signaling.2016
Author(s)
Yamaguchi, N.-t., Shibazaki, M., Yamada, C., Anzai, R., and Yamaguchi, N.
Organizer
Keystone Symposia on Molecular and Cellular Biology, Nuclear Receptors
Place of Presentation
Snowbird, USA
Year and Date
2016-01-13
Related Report
Int'l Joint Research
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