| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
In this study, I investigated molecular mechanisms, by which SAP-1, a gastrointestinal epithelial-specific protein tyrosine phosphatase, and its putative substrate p100 in intestinal epithelial cells modulate intestinal immunity. The pathological roles of these molecules were also examined. I found that ablation of p100 as well as that of SAP-1 markedly increased the severity of colitis in IL-10-deficeint mice. I also found that p90 was another putative substrate for SAP-1 at the microvilli of intestinal epithelial cells. Therefore, SAP-1, through de-phopshorylation of p100 and p90, is likely to contribute to the modulation of intestinal immunity by intestinal epithelial cells.
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