Regulation of intestinal immunity by a gastrointestinal epithelial-specific protein tyrosine phosphatase and its pathological role.
Project/Area Number |
25460366
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General medical chemistry
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Research Institution | Kobe University |
Principal Investigator |
Murata Yoji 神戸大学, 医学(系)研究科(研究院), 准教授 (60400735)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | チロシンホスファターゼ / 腸上皮細胞 / 腸管免疫 / 腸炎 / がん / チロシンホスタファーゼ |
Outline of Final Research Achievements |
In this study, I investigated molecular mechanisms, by which SAP-1, a gastrointestinal epithelial-specific protein tyrosine phosphatase, and its putative substrate p100 in intestinal epithelial cells modulate intestinal immunity. The pathological roles of these molecules were also examined. I found that ablation of p100 as well as that of SAP-1 markedly increased the severity of colitis in IL-10-deficeint mice. I also found that p90 was another putative substrate for SAP-1 at the microvilli of intestinal epithelial cells. Therefore, SAP-1, through de-phopshorylation of p100 and p90, is likely to contribute to the modulation of intestinal immunity by intestinal epithelial cells.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Protein tyrosine phosphatase SAP-1 protects against colitis through regulation of CEACAM20 in the intestinal epithelium2015
Author(s)
Y Murata, T Kotani, Y Supriatna, Y Kitamura, S Imada, K Kawahara, M Nishio, EW Daniwijaya, H Sadakata, S Kusakari, M Mori, Y Kanazawa, Y Saito, K Okawa, M Takeda-Morishita, H Okazawa, H Ohnishi, T Azuma, A Suzuki, T Matozaki
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Journal Title
Proc Natl Acad Sci U S A
Volume: 112
Issue: 31
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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