Analyses of the generation mechanisms for the bioactive lipids N-acylethanolamines
| Project/Area Number |
25460370
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Kagawa University |
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Principal Investigator |
UEDA Natsuo 香川大学, 医学部, 教授 (20193807)
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| Co-Investigator(Kenkyū-buntansha) |
UYAMA Toru 香川大学, 医学部, 助教 (30457337)
TSUBOI Kazuhito 香川大学, 医学部, 助教 (80346642)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | アシルトランスフェラーゼ / アナンダミド / オレオイルエタノールアミド / 酵素 / 脂質メディエーター / 脂肪酸エタノールアミド / パルミトイルエタノールアミド / リン脂質 / N-アシルトランスフェラーゼ / N-アシルホスファチジルエタノールアミン / グリセロホスホジエステラーゼ / リゾホスホリパーゼD / NAPE-PLD / PLA/ATファミリー |
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| Outline of Final Research Achievements |
N-Acylethanolamines (NAEs) are enzymatically formed from phospholipids in animal tissues and function as lipid mediators. We showed that phospholipase A/acyltransferase-1 (PLAAT-1) acts as N-acyltransferase generating N-acyl-phosphatidylethanolamines (NAPEs), precursors of NAEs in living cells and that glycerophosphodiesterase 4 (GDE4) produces NAEs from lysoNAPEs as a lysophospholipase D.
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Report
(4 results)
Research Products
(40 results)
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[Presentation] Glycerophosphodiesterase GDE4 is a novel lysophospholipase D-type enzyme generating N-acylethanolamines2015
Author(s)
Tsuboi, K., Okamoto, Y., Rahman, I.A.S., Uyama, T., Tokumura, A., Ueda, N.
Organizer
25th Annual Symposium of the International Cannabinoid Research Society
Place of Presentation
Wolfville, Nova Scotia (Canada)
Year and Date
2015-06-28
Related Report
Int'l Joint Research
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