Physiological and pathological roles of a new lipid mediator, 12-HHT
| Project/Area Number |
25460374
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Juntendo University |
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Principal Investigator |
OKUNO TOSHIAKI 順天堂大学, 医学(系)研究科(研究院), 准教授 (60361466)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 12-HHT / BLT2 / 脂肪酸 / エイコサノイド / ゼブラフィッシュ / 皮膚 / バリア / 創傷治癒 / 生理活性脂質 / GPCR / プロスタグランジン / ロイコトリエン / トロンボキサン |
|---|
| Outline of Final Research Achievements |
We identified one BLT1-type receptor and two BLT2-type receptors in zebrafish and revealed that the LTB4-BLT1 axis is involved in epiboly in zebrafish development.
We also revealed that the 12-HHT/BLT2 axis accelerated wound closure through the enhanced migration of epidermal keratinocytes.
We identified that the 12-HHT/BLT2 axis enhanced epidermal barrier function by increasing CLDN4 expression via Gi protein-p38 MAPK pathway.
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Report
(4 results)
Research Products
(66 results)
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[Journal Article] 12-hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2 receptor.2014
Author(s)
Liu M, Saeki K, Matsunobu T, Okuno T, Koga T, Sugimoto Y, Yokoyama C, Nakamizo S, Kabashima K, Narumiya S, Shimizu T, Yokomizo T
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Journal Title
J Exp Med
Volume: 211
Issue: 6
Pages: 1063-1078
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] 12-hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2 receptor.2014
Author(s)
Liu M., Saeki K., Matsunobu T., Okuno T., Koga T., Sugimoto Y., Yokoyama C, Nakamizo S., Kabashima K., Narumiya S., Shimizu T., Yokomizo T.
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Journal Title
J. Exp. Med.
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] Leukotriene B4 receptor BLT2 negatively regulates allergic airway eosinophilia.2013
Author(s)
Matsunaga Y., Fukuyama S., Okuno T., Sasaki F., Matsunobu T., Asai Y., Matsumoto K., Saeki K., Oike M., Sadamura Y., Machida K., Nakanishi Y., Kubo M., Yokomizo T., Inoue H.
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Journal Title
FASEB J.
Volume: 27
Issue: 8
Pages: 3306-3314
DOI
Related Report
Peer Reviewed
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