Physiological and pathological roles of a new lipid mediator, 12-HHT

• Project/Area Number: 25460374
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General medical chemistry
• Research Institution: Juntendo University
• Principal Investigator: OKUNO TOSHIAKI 順天堂大学, 医学(系)研究科(研究院), 准教授 (60361466)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 12-HHT / BLT2 / 脂肪酸 / エイコサノイド / ゼブラフィッシュ / 皮膚 / バリア / 創傷治癒 / 生理活性脂質 / GPCR / プロスタグランジン / ロイコトリエン / トロンボキサン

Outline of Final Research Achievements

We identified one BLT1-type receptor and two BLT2-type receptors in zebrafish and revealed that the LTB4-BLT1 axis is involved in epiboly in zebrafish development.
We also revealed that the 12-HHT/BLT2 axis accelerated wound closure through the enhanced migration of epidermal keratinocytes.
We identified that the 12-HHT/BLT2 axis enhanced epidermal barrier function by increasing CLDN4 expression via Gi protein-p38 MAPK pathway.

Research Products

• [Journal Article] Leukotriene B4 receptor type 2 (BLT2) enhances skin barrier function by regulating tight junction proteins. (2016)
  • Author(s): Ishii Y, Saeki K, Liu M, Sasaki F, Koga T, Kitajima K, Meno C, Okuno T, Yokomizo T
  • Journal Title: FASEB J Volume: 30 Issue: 2 Pages: 933-947
  • DOI: 10.1096/fj.15-279653
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Modulation of leukotriene B4 receptor 1 signaling by receptor for advanced glycation end products, RAGE. (2016)
  • Author(s): Ichiki T, Koga T, Okuno T, Saeki K, Yamamoto Y, Yamamoto H, Sakaguchi M, Yokomizo T
  • Journal Title: FASEB J Volume: 30 Issue: 5 Pages: 1811-1822
  • DOI: 10.1096/fj.201500117
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Identification of the old and new lipid mediator, 12-HHT and the role in skin wound healing (2015)
  • Author(s): 奥野利明
  • Journal Title: 生化学 Volume: 87 Issue: 1 Pages: 125-128
  • DOI: 10.14952/SEIKAGAKU.2015.870125
  • NAID: 40020383740
  • ISSN: 0037-1017
  • Year and Date: 2015-02-25
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] An inhaled phosphodiesterase 4 inhibitor E6005 suppresses pulmonary inflammation in mice (2015)
  • Author(s): Kubota S, Watanabe M, Shirato M, Okuno T, Higashimoto I, Machida K, Yokomizo T, Inoue H
  • Journal Title: Eur J Pharmacol Volume: 768 Pages: 41-48
  • DOI: 10.1016/j.ejphar.2015.10.013
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Biochemical characterization of three BLT receptors in zebrafish. (2015)
  • Author(s): Okuno T, Ishitani T, Yokomizo T.
  • Journal Title: PLoS ONE Volume: 10 Issue: 3 Pages: 0117888-0117888
  • DOI: 10.1371/journal.pone.0117888
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 12-hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2 receptor. (2014)
  • Author(s): Liu M, Saeki K, Matsunobu T, Okuno T, Koga T, Sugimoto Y, Yokoyama C, Nakamizo S, Kabashima K, Narumiya S, Shimizu T, Yokomizo T
  • Journal Title: J Exp Med Volume: 211 Issue: 6 Pages: 1063-1078
  • DOI: 10.1084/jem.20132063
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Individual variation of human S1P1 coding sequence leads to heterogeneity in receptor function and drug interactions. (2014)
  • Author(s): Obinata H, Gutkind S, Stitham J, Okuno T, Yokomizo T, Hwa J, Hla T
  • Journal Title: J Lipid Res Volume: 55 Issue: 12 Pages: 2665-2675
  • DOI: 10.1194/jlr.p054163
  • Peer Reviewed
• [Journal Article] IL-27 affects helper T cell responses via regulation of PGE2 production by macrophages. (2014)
  • Author(s): Y. Sato, H. Hara, T. Okuno, N. Ozaki, S. Suzuki, T. Yokomizo, T. Kaisho, H. Yoshida.
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 451 Issue: 2 Pages: 215-221
  • DOI: 10.1016/j.bbrc.2014.07.096
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 12-hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2 receptor. (2014)
  • Author(s): Liu M., Saeki K., Matsunobu T., Okuno T., Koga T., Sugimoto Y., Yokoyama C, Nakamizo S., Kabashima K., Narumiya S., Shimizu T., Yokomizo T.
  • Journal Title: J. Exp. Med. Volume: in press
  • Peer Reviewed
• [Journal Article] Leukotriene B4 receptor BLT2 negatively regulates allergic airway eosinophilia. (2013)
  • Author(s): Matsunaga Y., Fukuyama S., Okuno T., Sasaki F., Matsunobu T., Asai Y., Matsumoto K., Saeki K., Oike M., Sadamura Y., Machida K., Nakanishi Y., Kubo M., Yokomizo T., Inoue H.
  • Journal Title: FASEB J. Volume: 27 Issue: 8 Pages: 3306-3314
  • DOI: 10.1096/fj.12-217000
  • Peer Reviewed
• [Journal Article] Thromboxane A synthase-independent production of 12-hydroxyheptadecatrienoic acid, a BLT2 ligand. (2013)
  • Author(s): Matsunobu T., Okuno T., Yokoyama C., Yokomizo T.
  • Journal Title: J. Lipid Res. Volume: 54 Issue: 11 Pages: 2979-2987
  • DOI: 10.1194/jlr.m037754
  • Peer Reviewed
• [Journal Article] Synthesis of (S,5Z,8E,10E)-12-Hydroxyheptadeca-5,8,10-trienoic Acid(12S-HHT) and its Analogues. (2013)
  • Author(s): Tojo T, Wang Q, Okuno T, Yokomizo T, Kobayashi Y.
  • Journal Title: Synlett Volume: 24 Pages: 1545-1548
  • Peer Reviewed
• [Journal Article] 脂質抽出法 (2013)
  • Author(s): 奥野利明
  • Journal Title: 遺伝子医学MOOK 24, 最新生理活性脂質研究 Volume: 24 Pages: 26-31
• [Presentation] ロイコトリエンB4第一受容体BLT1とRAGEは機能的に相互作用する. (2015)
  • Author(s): 市木貴子, 古賀友紹, 奥野利明, 佐伯和子, 阪口政清, 山本靖彦, 横溝岳彦.
  • Organizer: 第38回日本分子生物学会年会・第88回日本生化学会大会 合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-01
• [Presentation] ロイコトリエンB4第二受容体(BLT2)は角膜創傷治癒を促進する. (2015)
  • Author(s): 岩本怜, 古賀友紹, 奥野利明, 松田彰, 村上晶, 横溝岳彦.
  • Organizer: 第38回日本分子生物学会年会・第88回日本生化学会大会 合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-01
• [Presentation] CRISPR/Cas9によるロイコトリエンA4水解酵素欠損マウスの作製. (2015)
  • Author(s): 古賀 友紹, 奥野 利明, 佐伯 和子, 中村衣里, 多田昇弘, 横溝岳彦.
  • Organizer: 第38回日本分子生物学会年会・第88回日本生化学会大会 合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-01
• [Presentation] ロイコトリエンB4第一受容体(BLT1)とFLAGタグに対するマウス単クローン抗体のヒトキメラ化. (2015)
  • Author(s): 池田恒基, 佐々木文之, 上野あゆみ, 佐伯和子, 奥野利明, 古賀友紹, 横溝岳彦.
  • Organizer: 第38回日本分子生物学会年会・第88回日本生化学会大会 合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-01
• [Presentation] ロイコトリエンB4第二受容体BLT2は急性肺傷害時に肺保護作用を発揮する. (2015)
  • Author(s): 重松美沙子, 古賀友紹, 佐伯和子, 奥野利明, 外須美夫, 横溝岳彦.
  • Organizer: 第38回日本分子生物学会年会・第88回日本生化学会大会 合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-01
• [Presentation] Pneumolysin誘導性急性肺傷害におけるBLT2の肺保護作用. (2015)
  • Author(s): 重松美沙子, 古賀友紹, 佐伯和子, 奥野利明, 横溝岳彦.
  • Organizer: 第12回東京呼吸器リサーチフォーラム
  • Place of Presentation: 東京
  • Year and Date: 2015-11-14
• [Presentation] 変形性膝関節症患者における関節内酸化ストレスとω3不飽和脂肪酸の検討. (2015)
  • Author(s): 若山貴則, 齋田良知, 小林洋平, 奥野利明, 横溝岳彦, 倉田憲一, 鎌野俊哉, 深作進, 金子和夫, 根本昌幸.
  • Organizer: 第88回日本整形外科学会基礎学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2015-10-22
• [Presentation] 角膜損傷の新規治療薬としての脂質メディエーターの可能性. (2015)
  • Author(s): 岩本怜, 古賀友紹, 奥野利明, 村上晶, 横溝岳彦, 松田彰.
  • Organizer: 第35回日本眼薬理学会
  • Place of Presentation: 東京
  • Year and Date: 2015-09-05
• [Presentation] Crucial role of the 12-HHT receptor BLT2 in epidermal wound healing. (2015)
  • Author(s): Liu M., Saeki K., Okuno T., Koga T., Yokomizo T. Crucial role of the 12-HHT receptor BLT2 in epidermal wound healing.
  • Organizer: 14th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases
  • Place of Presentation: Budapest
  • Year and Date: 2015-07-12
  • Int'l Joint Research
• [Presentation] BLT2 protects against mouse acute lung injury caused by a pneumococcal toxin pneumolysin. (2015)
  • Author(s): Shigematsu M., Koga T., Saeki K., Okuno T., Hoka S., Yokomizo T.
  • Organizer: 14th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases
  • Place of Presentation: Budapest
  • Year and Date: 2015-07-12
  • Int'l Joint Research
• [Presentation] ロイコトリエンB4第二受容体 (BLT2) は角膜創傷治癒を促進する. (2015)
  • Author(s): 岩本怜, 古賀友紹, Liu Min, 奥野利明, 松田彰, 横溝岳彦, 村上晶.
  • Organizer: 日本眼科学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2015-04-16
• [Presentation] Distinct roles of BLT1hi DCs and BLT1lo DCs in activating T cells. (2015)
  • Author(s): Koga T, Sasaki F, Saeki K, Ichiki T, Okuno T, Yokomizo T.
  • Organizer: Keystone Symposium
  • Place of Presentation: Montreal
  • Year and Date: 2015-03-08
• [Presentation] Leukotriene B4 receptor 1 signaling promotes neovascular age-related macular degeneration. (2015)
  • Author(s): Sasaki F, Koga T, Saeki K, Okuno T, Yokomizo T.
  • Organizer: Keystone Symposium
  • Place of Presentation: Montreal
  • Year and Date: 2015-03-08
• [Presentation] Identification and charactarization of zebrafish BLT1 and BLT2. (2015)
  • Author(s): Okuno T, Ishitani T, Yokomizo T.
  • Organizer: 6th International Conference on Phospholipase A2 and Lipid Mediators
  • Place of Presentation: Tokyo
  • Year and Date: 2015-02-10 – 2015-02-12
• [Presentation] Functional Interplay between the Leukotriene B4 receptor BLT1 and RAGE. (2015)
  • Author(s): Ichiki T, Koga T, Okuno T, Saeki K, Yamamoto Y, Sakaguchi M, Yokomizo T.
  • Organizer: 6th International Conference on Phospholipase A2 and Lipid Mediators
  • Place of Presentation: Tokyo
  • Year and Date: 2015-02-10 – 2015-02-12
• [Presentation] Leukotriene B4 receptor BLT2 enhances the formation of epithelial barrier by increasing claudin-4 expression. (2015)
  • Author(s): Ishii Y, Saeki K, Min L, Okuno T, Yokomizo T.
  • Organizer: 6th International Conference on Phospholipase A2 and Lipid Mediators
  • Place of Presentation: Tokyo
  • Year and Date: 2015-02-10 – 2015-02-12
• [Presentation] 12-HHT accelerates corneal wound healing through leukotriene B4 receptor 2 (BLT2). (2015)
  • Author(s): Iwamoro R, Koga T, Min L, Mtsuda A, Murakami A, Yokomizo T.
  • Organizer: 6th International Conference on Phospholipase A2 and Lipid Mediators
  • Place of Presentation: Tokyo
  • Year and Date: 2015-02-10 – 2015-02-12
• [Presentation] BLT1 defines dendritic cell subsets with different characteristics in differentiation and proliferation of T cells (2015)
  • Author(s): Koga T, Sasaki F, Saeki K, Ichiki T, Okuno T, Yokomizo T.
  • Organizer: 6th International Conference on Phospholipase A2 and Lipid Mediators
  • Place of Presentation: Tokyo
  • Year and Date: 2015-02-10 – 2015-02-12
• [Presentation] 12-HHT promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2 receptor (2015)
  • Author(s): Saeki K, Min L, Matsunobu T, Okuno T, Koga T, Nakamizo S, Kabashima K, Yokomizo T.
  • Organizer: 6th International Conference on Phospholipase A2 and Lipid Mediators
  • Place of Presentation: Tokyo
  • Year and Date: 2015-02-10 – 2015-02-12
• [Presentation] M2 macrophages promote neovascular age-related macular degeneration thorugh the activation of the leukotriene B4 receptor 1 signaling. (2015)
  • Author(s): Sasaki F, Koga T, Saeki K, Okuno T, Yokomizo T.
  • Organizer: 6th International Conference on Phospholipase A2 and Lipid Mediators
  • Place of Presentation: Tokyo
  • Year and Date: 2015-02-10 – 2015-02-12
• [Presentation] BLT2 protects against mouse acute lung injury induced by pneumococcal toxin pneumolysin. (2015)
  • Author(s): Shigematsu M, Koga T, Okuno T, Saeki K, Hoka S, Yokomizo T.
  • Organizer: 6th International Conference on Phospholipase A2 and Lipid Mediators
  • Place of Presentation: Tokyo
  • Year and Date: 2015-02-10 – 2015-02-12
• [Presentation] Multiplexed quantitative analysis of eicosanoids in pregnant women (2015)
  • Author(s): Takahashi N, Okuno T, Ooba M, Makino S, Takeda S, Yokomizo T.
  • Organizer: 6th International Conference on Phospholipase A2 and Lipid Mediators
  • Place of Presentation: Tokyo
  • Year and Date: 2015-02-10 – 2015-02-12
• [Presentation] Leukotriene B4 receptor 1 signaling promotes neovascular age-related macular degeneration. (2014)
  • Author(s): Sasaki F, Koga T, Saeki K, Okuno T, Yokomizo T
  • Organizer: 第43回日本免疫学会総会
  • Place of Presentation: 東京
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] ロイコトリエンB4第一受容体BLT1とRAGEの相互作用. (2014)
  • Author(s): 市木貴子, 古賀友紹, 奥野利明, 阪口政清, 横溝岳彦
  • Organizer: 第11回東京呼吸器リサーチフォーラム
  • Place of Presentation: 東京
  • Year and Date: 2014-11-01
• [Presentation] 質量分析計を用いた妊産婦血中エイコサノイドの測定 (2014)
  • Author(s): 高橋七瀬, 奥野利明, 大塲麻生, 牧野真太郎, 竹田省, 横溝岳彦
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2014-10-15 – 2014-10-18
• [Presentation] ロイコトリエンB4第一受容体BLT1陽性樹状細胞はTh1分化誘導を促進する. (2014)
  • Author(s): 古賀友紹, 佐々木文之, 佐伯和子, 市木貴子, 奥野利明, 横溝岳彦.
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2014-10-15 – 2014-10-18
• [Presentation] ロイコトリエンB4第二受容体BLT2の角膜創傷治癒における役割. (2014)
  • Author(s): 岩本怜, 古賀友紹, Liu M, 奥野利明, 松田彰, 村上晶, 横溝岳彦
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2014-10-15 – 2014-10-18
• [Presentation] ロイコトリエンB4第一受容体BLT1とRAGEの相互作用. (2014)
  • Author(s): 市木貴子, 古賀友紹, 奥野利明, 阪口政清, 横溝岳彦.
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2014-10-15 – 2014-10-18
• [Presentation] 上皮細胞間接着におけるロイコトリエンＢ4第二受容体(BLT2)の役割の解明. (2014)
  • Author(s): 石井由美子, 佐伯和子, Liu M, 奥野利明, 横溝岳彦.
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2014-10-15 – 2014-10-18
• [Presentation] Pneumolysin誘導性急性肺傷害モデルにおけるBLT2の肺保護作用 (2014)
  • Author(s): 重松美沙子, 古賀友紹, 奥野利明, 佐伯和子, 横溝岳彦
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2014-10-15 – 2014-10-18
• [Presentation] 新規樹状細胞サブセットマーカー分子としてのロイコトリエンB4受容体. (2014)
  • Author(s): 古賀友紹, 佐々木文之, 佐伯和子, 市木貴子, 奥野利明, 横溝岳彦
  • Organizer: 第35回日本炎症・再生学会
  • Place of Presentation: 沖縄
  • Year and Date: 2014-07-01 – 2014-07-04
• [Presentation] Biosynthetic pathway of 12-hydroxyheptadecatrienoic acid revealed by LC-MS/MS system. (2014)
  • Author(s): Okuno T, Matsunobu T, Yokomizo T.
  • Organizer: 62nd ASMS Conference
  • Place of Presentation: Baltimore
  • Year and Date: 2014-06-15 – 2014-06-19
• [Presentation] ロイコトリエンB4第二受容体（BLT2）による細胞間接着増強作用. (2014)
  • Author(s): 石井由美子, 佐伯和子, Min L, 奥野利明, 横溝岳彦
  • Organizer: 平成26年度日本生化学会九州支部例会
  • Place of Presentation: 福岡
  • Year and Date: 2014-05-18
• [Presentation] Crucial role of the 12-HHT receptor BLT2 in epidermal wound healing. (2014)
  • Author(s): Liu M, Saeki K, Okuno T, Koga T, Sugimoto Y, Yokomizo T.
  • Organizer: 第11回GPCR研究会
  • Place of Presentation: 東京
  • Year and Date: 2014-05-09 – 2014-05-10
• [Presentation] The relationships between corneal wound healing and leukotriene B4 receptor 2 (BLT2) in Balb/c mice (2014)
  • Author(s): Iwamoto S, Koga T, Liu M, Ohba M, Okuno T, Matsuda A, Yokomizo T, Murakami A.
  • Organizer: Annual meeting of the Association for Research in Vision and Ophthalmology
  • Place of Presentation: Orlando
  • Year and Date: 2014-05-04 – 2014-05-08
• [Presentation] 新規樹状細胞サブセットマーカー分子としてのロイコトリエンB4受容体. (2014)
  • Author(s): 古賀友紹, 佐々木文之, 佐伯和子, 奥野利明, 横溝岳彦.
  • Organizer: 第134回日本薬学会
  • Place of Presentation: 熊本
• [Presentation] 12-HHT受容体BLT2の上皮保護作用. (2014)
  • Author(s): 奥野利明.
  • Organizer: 日本薬学会第134回年会
  • Place of Presentation: 熊本
  • Invited
• [Presentation] ロイコトリエンB4第二受容体(BLT2)の皮膚創傷治癒における促進的役割. (2013)
  • Author(s): Liu M., 佐伯和子, 松延武彦, 奥野利明, 中溝聡, 椛島健治, 横溝岳彦.
  • Organizer: 第55回日本脂質生化学会
  • Place of Presentation: 松島
• [Presentation] 新規樹状細胞サブセットマーカーとしてのBLT1受容体. (2013)
  • Author(s): 古賀友紹, 佐々木文之, 佐伯和子, 奥野利明, 横溝岳彦.
  • Organizer: 第55回日本脂質生化学会
  • Place of Presentation: 松島
• [Presentation] マウスBLT1およびDYKDDDDK配列に対して高親和性を有するヒト化単クローン抗体の樹立. (2013)
  • Author(s): 佐々木文之, 池田恒基, 上野あゆみ, 佐伯和子, 奥野利明, 古賀友紹, 横溝岳彦.
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 横浜
• [Presentation] トロンボキサン合成酵素非依存的な12-HHT産生機構. (2013)
  • Author(s): 奥野利明, 松延武彦, 横溝岳彦.
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 横浜
• [Presentation] ロイコトリエンB4第二受容体(BLT2)の細胞接着形成における役割. (2013)
  • Author(s): 石井由美子, 佐伯和子, Min Liu., 奥野利明, 横溝岳彦.
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 横浜
• [Presentation] BLT1 defines a DC1 subset that induces Th1 differentiation by releasing IL-12p35. (2013)
  • Author(s): Koga T., Sasaki F., Saeki K., Ichiki T., Okuno T., Yokomizo T.
  • Organizer: 第42回日本免疫学会
  • Place of Presentation: 千葉
• [Presentation] Physiological and pathological roles of leukotriene B4 receptor 1 in M2 macrophages. (2013)
  • Author(s): Sasaki F., Koga T., Saeki K., Okuno T., Yokomizo T.
  • Organizer: 第42回日本免疫学会
  • Place of Presentation: 千葉
• [Presentation] BLT2の生体内リガンド・12-HHTの生合成機構の解明. (2013)
  • Author(s): 奥野利明.
  • Organizer: 第4回公開シンポジウム. 天然物ケミカルバイオロジー ～分子標的と活性制御～
  • Place of Presentation: つくば
• [Presentation] Generation, characterization and humanization of high-affinity monoclonal antibody against leukotriene B4 receptor 1 (BLT1). (2013)
  • Author(s): Ikeda K., Sasaki F., Ueno A., Okuno T., Koga T., Yokomizo T.
  • Organizer: Faseb SRC: Lysophospholipid and Other Related Medaitors-From Bench to Clinic
  • Place of Presentation: Niseko
• [Presentation] Role of leukotriene B4 receptor BLT1 in dendritic cells. (2013)
  • Author(s): Koga T., Sasaki F., Saeki K., Ichiki T., Okuno T., Yokomizo T.
  • Organizer: Faseb SRC: Lysophospholipid and Other Related Medaitors-From Bench to Clinic
  • Place of Presentation: Niseko
• [Presentation] The physiological function of a leukotriene B4 receptor 1 in M2 macrophages. (2013)
  • Author(s): Sasaki F., Koga T., Saeki K., Okuno T., Yokomizo T.
  • Organizer: Faseb SRC: Lysophospholipid and Other Related Medaitors-From Bench to Clinic
  • Place of Presentation: Niseko
• [Presentation] Biosynthetic pathway of 12-hydroxyeicosatetraenoic acid, a BLT2 ligand. (2013)
  • Author(s): Okuno T., Matunobu T., Yokoyama C., Yokomizo T.
  • Organizer: 13th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases
  • Place of Presentation: San Juan
• [Presentation] Leukotriene B4 receptor 1 is a potential marker of mouse dendritic cells. (2013)
  • Author(s): Koga T., Sasaki F., Saeki K., Ichiki T., Okuno T., Yokomizo T.
  • Organizer: The 8th Korea-Japan Conference on Cellular Signaling for Young Scientists
  • Place of Presentation: Fukuoka
• [Presentation] Physiological and pathological roles of leukotriene B4 receptor 1 in M2 macrophages. (2013)
  • Author(s): Sasaki F., Koga T., Saeki K., Okuno T., Yokomizo T.
  • Organizer: The 8th Korea-Japan Conference on Cellular Signaling for Young Scientists
  • Place of Presentation: Fukuoka
• [Remarks] 順天堂大学医学部 生化学第一講座
  • URL: http://plaza.umin.ac.jp/j_bio/Biochem1/Top.html
• [Remarks] Publication List
  • URL: http://plaza.umin.ac.jp/j_bio/Biochem1/Publications.html