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Development of LIX1L target-peptide therapy in gastric cancer

Research Project

Project/Area Number 25460384
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pathological medical chemistry
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

NAKAMURA Satoki  浜松医科大学, 医学部, 特任研究員 (20377740)

Co-Investigator(Kenkyū-buntansha) SHIBATA Kiyoshi  浜松医科大学, 光尖端医学教育研究センター, 技術専門員 (80397372)
FUJIE Michio  浜松医科大学, 光尖端医学教育研究センター, 技術補佐員 (90397373)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords分子標的薬 / LIX1L蛋白質 / 胃癌 / miRNA / LIX1L / RNA結合蛋白質 / 癌細胞 / 標的分子 / チロシンキナーゼ阻害 / ペプチド / プロテオーム解析 / シグナル伝達
Outline of Final Research Achievements

We identified the LIX1L, which specifically expressed in various cancer cells, as a novel marker for cancer. Its function is unknown in detail. In this study, we revealed that LIX1L promoted cancer cell proliferation both in vitro and in vivo. ROS1 kinase phosphorylates 136th Tyrosin in LIX1L, and LIX1L subsequently induces proliferates cancer cells via binding to various RMA including miRNA. We also found peptide, which specifically inhibited the function of LIX1L, and the peptide inhibited gastric cancer cell proliferation as a decay. Therefore, we revealed that LIX1L was specifically expressed in various cancer cells, and the PY136 peptide, which targeted to LIX1L amino acid sequence including 136th Tyrosin, has a possibility as a new molecular targeted agent for cancer therapy in LIX1L expressed cancer cells.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (22 results)

All 2016 2015 2014 2013 2011 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Open Access: 6 results,  Acknowledgement Compliant: 5 results) Presentation (7 results) Patent(Industrial Property Rights) (6 results) (of which Overseas: 3 results)

  • [Journal Article] Novel roles for LIX1L in promoting cancer cell proliferation through ROS1-mediated LIX1L phosphorylation.2015

    • Author(s)
      Nakamura S, Kahyo T, Tao H, Shibata K, Kurabe N, Yamada H, Shinmura K, Ohnishi K, Sugimura H.
    • Journal Title

      Sci Rep.

      Volume: 5 Issue: 1 Pages: 13474-13474

    • DOI

      10.1038/srep13474

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] NEIL1 p.Gln282Stop variant is predominantly localized in the cytoplasm and exhibits reduced activity in suppressing mutations.2015

    • Author(s)
      Shinmura K, Kato H, Kawanishi Y, Goto M, Tao H, Inoue Y, Nakamura S, Sugimura H.
    • Journal Title

      Gene.

      Volume: 571 Issue: 1 Pages: 33-42

    • DOI

      10.1016/j.gene.2015.06.043

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] CD44-SLC1A2 fusion transcripts in primary colorectal cancer.2015

    • Author(s)
      Shinmura K, Kato H, Igarashi H, Inoue Y, Nakamura S, Du C, Kurachi K, Nakamura T, Ogawa H, Tanahashi M, Niwa H, Sugimura H.
    • Journal Title

      Pathol Oncol Res.

      Volume: 21 Issue: 3 Pages: 759-764

    • DOI

      10.1007/s12253-014-9887-2

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] CLCA2 as a novel immunohistochemical marker for differential diagnosis of squamous cell carcinoma from adenocarcinoma of the lung.2014

    • Author(s)
      Shinmura K, Igarashi H, Kato H, Kawanishi Y, Inoue Y, Nakamura S, Ogawa H, Yamashita T, Kawase A, Funai K, Sugimura H.
    • Journal Title

      Dis Markers.

      Volume: 2014 Pages: 619273-619273

    • DOI

      10.1155/2014/619273

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] RSPO fusion transcripts in colorectal cancer in Japanese population.2014

    • Author(s)
      Shinmura K, Kahyo T, Kato H, Igarashi H, Matsuura S, Nakamura S, Kurachi K, Nakamura T, Ogawa H, Funai K, Tanahashi M, Niwa H, Sugimura H.
    • Journal Title

      Mol Biol Rep.

      Volume: 41 Issue: 8 Pages: 5375-5384

    • DOI

      10.1007/s11033-014-3409-x

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Impaired 8-hydroxyguanine repair activity of MUTYH variant p. Arg109Trp found in a Japanese patient with early-onset colorectal cancer2014

    • Author(s)
      Shinmura, K., Goto, M., Tao, H., Kato, H., Suzuki, R., Nakamura, S., Matsuda, T., Yin, G., Morita, M., Kono, S., Sugimura, H.
    • Journal Title

      Oxidative Medicine and Cellular Longevity

      Volume: 2014 Pages: 617351-617351

    • DOI

      10.1155/2014/617351

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A novel somatic FGFR3 mutation in primary lung cancer2014

    • Author(s)
      Shinmura K, Sugimura H et al.
    • Journal Title

      Oncol Rep

      Volume: 31(3) Issue: 3 Pages: 1219-24

    • DOI

      10.3892/or.2014.2984

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] TNK2 gene amplification is a novel predictor of a poor prognosis in patients with gastric cancer2014

    • Author(s)
      Shinmura K, Sugimura H et al.
    • Journal Title

      J Surg Oncol

      Volume: 109(3) Issue: 3 Pages: 189-97

    • DOI

      10.1002/jso.23482

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] JmjC-domain containing histone demethylase 1B-mediated P15(Ink4b) suppression promotes the proliferation of leukemic progenitor cells through modulation of cell cycle progression in acute myeloid leukemia2011

    • Author(s)
      Nakamura S, Ohnishi K, et al
    • Journal Title

      Molecular Carcinogenesis

      Volume: (In press) Issue: 1 Pages: 57-69

    • DOI

      10.1002/mc.20878

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] がんの創薬標的としてのLIX1Lおよびそのリン酸化阻害剤2015

    • Author(s)
      中村 悟己
    • Organizer
      DSANJ疾患別商談会(がん領域)
    • Place of Presentation
      大阪
    • Year and Date
      2015-01-29
    • Related Report
      2014 Research-status Report 2013 Research-status Report
  • [Presentation] 腫瘍新規発現蛋白質を標的としたペプチド抗腫瘍薬2014

    • Author(s)
      中村 悟己
    • Organizer
      BioJapan
    • Place of Presentation
      横浜
    • Year and Date
      2014-10-15 – 2014-10-17
    • Related Report
      2014 Research-status Report 2013 Research-status Report
  • [Presentation] IER5/Cdc25Bをターゲットとする低分子量リン糖抗腫瘍剤の調製及び評価2014

    • Author(s)
      山下光司、牧田礼子、山岡真弓、藤江三千男、中村悟己、押川達夫、山下純子、近藤 満、平川和貴、戸田三津夫、田中康隆、大西一功、椙村春彦
    • Organizer
      日本化学会第94回春季年会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Research-status Report
  • [Presentation] 胃癌細胞におけるLIX1L蛋白質を標的とした阻害剤の開発2013

    • Author(s)
      中村 悟己、新村 和也、椙村 春彦
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] 新規合成リン糖誘導体TMPPの標的分子とその抗腫瘍効果のメカニズム2013

    • Author(s)
      中村 悟己、椙村 春彦
    • Organizer
      第17回日本がん分子標的治療学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
  • [Presentation] 新規合成リン糖誘導体TMPPの標的分子とその抗腫瘍効果のメカニズム2013

    • Author(s)
      中村悟己、藤江三千男、下光司、牧田礼子、山岡真弓、押川達夫、山下純子、近藤 満、平川和貴、戸田三津夫、田中康隆、大西一功、椙村春彦
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] 腫瘍新規発現蛋白質を標的としたペプチド抗腫瘍薬

    • Author(s)
      中村 悟己
    • Organizer
      JST新技術説明会中部地区医療・バイオ系シーズ発表会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Research-status Report
  • [Patent(Industrial Property Rights)] LIX1L高発現腫瘍細胞の増殖阻害方法、及び腫瘍細胞増殖抑制ペプチド2016

    • Inventor(s)
      中村 悟己、椙村 春彦
    • Industrial Property Rights Holder
      中村 悟己、椙村 春彦
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-02-17
    • Related Report
      2015 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] LIX1L高発現腫瘍細胞の増殖阻害方法、及び腫瘍細胞増殖抑制ペプチド2015

    • Inventor(s)
      中村 悟己、椙村 春彦
    • Industrial Property Rights Holder
      中村 悟己、椙村 春彦
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-511230
    • Filing Date
      2015-10-16
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] LIX1L高発現腫瘍細胞の増殖阻害方法、及び腫瘍細胞増殖抑制ペプチド2015

    • Inventor(s)
      中村 悟己、椙村 春彦
    • Industrial Property Rights Holder
      中村 悟己、椙村 春彦
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-11-06
    • Related Report
      2015 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 国際特許出願2014

    • Inventor(s)
      中村 悟己、椙村 春彦
    • Industrial Property Rights Holder
      中村 悟己、椙村 春彦
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-04-02
    • Related Report
      2014 Research-status Report
    • Overseas
  • [Patent(Industrial Property Rights)] 基礎出願2013

    • Inventor(s)
      中村 悟己、椙村 春彦
    • Industrial Property Rights Holder
      中村 悟己、椙村 春彦
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-082272
    • Filing Date
      2013-04-10
    • Related Report
      2013 Research-status Report
  • [Patent(Industrial Property Rights)] 優先権出願2013

    • Inventor(s)
      中村 悟己、椙村 春彦
    • Industrial Property Rights Holder
      中村 悟己、椙村 春彦
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-173696
    • Filing Date
      2013-08-23
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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