Molecular pathological studies on the effect of anticoagulant protein C pathway on the regulation of tumorgenesis
| Project/Area Number |
25460396
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Suzuka University of Medical Science |
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Principal Investigator |
Suzuki Koji 鈴鹿医療科学大学, 薬学部, 教授 (70077808)
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| Co-Investigator(Renkei-kenkyūsha) |
HAYASHI Tatsuya 三重県立看護大学, 看護学部, 教授 (00242959)
OKAMOTO Takayuki 三重大学, 医学(系)研究科, 助教 (30378286)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | プロテインC凝固制御系 / 抗凝固因子 / 腫瘍促進作用 / プロテインCインヒビター / 抗腫瘍作用 / 活性化プロテインC / トロンボモジュリン / プロテインC / 凝固制御因子 / β1-3グルカン / 自然免疫 / 腫瘍細胞 / 増殖 / 転移 / ヘパリン / プロテインＣ / プロテインＣインヒビター |
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| Outline of Final Research Achievements |
Protein C inhibitor (PCI), a member of the serine protease inhibitors, physiologically inhibits an anticoagulant serine protease, activated protein C (APC) and thrombin- thrombomodulin (TM) complex. In this study, we studied the effects of host PCI on growth and metastasis of B16 melanoma (B16) cells by comparing between wild-type mice and mice transgenic for human PCI gene (hPCI-TG). B16 cells growth and metastatic nodules of B16 cells in the lungs were developed in hPCI-TG mice, and fibrin deposition in the lung in hPCI-TG mice was increased more than in wild-type mice. The invasive behavior of B16 cells observed in hPCI-TG mice was reduced by anti-human PCI IgG, APC, or soluble TM administration. Present studies suggest that PCI stimulates tumor cell growth and metastasis via its procoagulant properties, and anticoagulant proteins regulate PCI-dependent tumor cell growth and metastasis.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] Host protein C inhibitor inhibits tumor growth, but promotes tumor metastasis, which is correlated with hypercoagulability.2015
Author(s)
Akita N, Ma N, Okamoto T, Asanuma K, Yoshida K, Nishioka J, Shimaoka M, Suzuki K, Hayashi T.
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Journal Title
Thrombosis research.
Volume: 135
Pages: 1203-1208
DOI
Related Report
Peer Reviewed
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[Journal Article] Thrombomodulin protects against ventilator-induced lung injury in rats.2014
Author(s)
Iwashita Y, Zhang E, Maruyama J, Yokochi A, Yamada Y, Sawada H, Mitani Y, Imai H, Suzuki K, Maruyama K.
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Journal Title
J. Intensive Care,
Volume: 2
Pages: 57-66
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