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Studies on thrombophilia -deficiency and mutation of protein S-

Research Project

Project/Area Number 25460398
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pathological medical chemistry
Research InstitutionNagasaki International University

Principal Investigator

HAMASAKI Naotaka  長崎国際大学, 薬学部, 客員教授 (00091265)

Co-Investigator(Kenkyū-buntansha) KUMA Hiroyuki  長崎国際大学, 薬学部, 准教授 (40435136)
HATAE Hinako  長崎国際大学, 薬学部, 助教 (00551582)
Research Collaborator TSUDA Tomohide  
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsプロテインS / 血栓性素因 / 深部静脈血栓症 / プロテインS比活性 / 比活性 / プロテインS
Outline of Final Research Achievements

In this study, we developed new assay system to be an effective screening tool for protein S (PS) deficiency. This assay named “PS specific activity test”was covered by insurance last year. When our new assay of PS specific activity was performed in blood samples of thrombosis patients, all of patients with low PS specific activity have genetic mutation. These data clearly show that protein S deficiency is one of major Japanese thrombophilia.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (19 results)

All 2016 2015 2014 2013 Other

All Journal Article (9 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 9 results,  Open Access: 2 results) Presentation (7 results) (of which Invited: 3 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Multianalyte Conventional Reference Material (MacRM): A Useful Tool for Nationwide Standardization of Laboratory Measurements for Medical Care-A Model Study in Japan2016

    • Author(s)
      Shinohara K, Hamasaki N, Takagi Y, Yatomi Y, Kikuchi H, Hosogaya S, Kawai Y, Miyachi H, Kaneko K, Miyajima Y, Matsumoto H, Yamamoto Y, Iwagami M, Osawa S, Umeda M, Koide H, Yoshimura D, Kato H
    • Journal Title

      Clinical Chemistry

      Volume: 62 Issue: 2 Pages: 392-406

    • DOI

      10.1373/clinchem.2015.245621

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] プロテインS比活性測定:易血栓症状態予知マーカー2015

    • Author(s)
      濱崎直孝
    • Journal Title

      臨床病理

      Volume: 63 Pages: 1412-1418

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystal structure of the anion exchanger domain of human erythrocyte band 32015

    • Author(s)
      Arakawa T, Kobayashi-Yurugi T, Alguel Y, Iwanari H, Hatae H, Iwata M, Abe Y, Hino T, Ikeda-Suno C, Kuma H, Kang D, Murata T, Hamakubo T, Cameron AD, Kobayashi T, Hamasaki N, Iwata S
    • Journal Title

      Science

      Volume: 350 Issue: 6261 Pages: 680-684

    • DOI

      10.1126/science.aaa4335

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 国際的な標準化活動とJSCC2014

    • Author(s)
      濱崎 直孝
    • Journal Title

      臨床検査

      Volume: 58 Pages: 150-155

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Beneficial effect of EPA (20:5 n-3 PUFA) on preventing venous thromboembolism: a rat tail thrombosis model experiment.2013

    • Author(s)
      Kuma H, Nagashima R, Hatae H, Tsuda T, Hamasaki N
    • Journal Title

      Thromb Res

      Volume: 131(1) Issue: 1 Pages: 107-108

    • DOI

      10.1016/j.thromres.2012.09.014

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Activated protein C anticoagulant system dysfunction and thrombophilia in Asia2013

    • Author(s)
      Hamasaki N, Kuma H, Tsuda H.
    • Journal Title

      Ann. Lab. Med.

      Volume: 33 Issue: 1 Pages: 8-13

    • DOI

      10.3343/alm.2013.33.1.8

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Phosphoenolpyruvate, a glycolytic intermediate, as a cytoprotectant and antioxidant in ex-vivo cold-preserved mouse liver: a potential application for organ preservation.2013

    • Author(s)
      Kondo Y, Ishitsuka Y, Kadowaki D, Fukumoto Y, Miyamoto Y, Irikura M, Hirata S, Sato K, Maruyama T, Hamasaki N, Irie T
    • Journal Title

      J Pharm Pharmacol

      Volume: 65(3) Issue: 3 Pages: 390-401

    • DOI

      10.1111/j.2042-7158.2012.01602.x

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Molecular basis of protein S deficiency in China.2013

    • Author(s)
      Tang L, Jian XR, Hamasaki N, Guo T, Wang HF, Lu X, Wang QY, Hu Y
    • Journal Title

      Am J Hematol

      Volume: 88(10) Pages: 899-905

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparative effects of phosphoenolpyruvate (PEP), a glycolytic intermediate, as an organ preservation agent with glucose and N-acetylcysteine against organ damage during cold storage of mouse liver and kidney2013

    • Author(s)
      Ishitsuka Y, Fukumoto Y, Kondo Y, Irikura M, Kadowaki D, Narita Y, Hirata S, Moriuchi H, Maruyama T, Hamasak N, Irie T
    • Journal Title

      ISRN Pharmacology

      Volume: 2013 Pages: 375825-375825

    • DOI

      10.1155/2013/375825

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 凝固亢進状態(易血栓症状態)の新しい判定法:プロテインS 比活性測定2016

    • Author(s)
      濱崎直孝
    • Organizer
      第38回日本血栓止血学会
    • Place of Presentation
      奈良春日野国際フォーラム
    • Year and Date
      2016-06-18
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] プロテインS 比活性測定:―検査データから診断する易血栓症状態―2016

    • Author(s)
      濱崎直孝
    • Organizer
      第38回日本血栓止血学会
    • Place of Presentation
      奈良春日野国際フォーラム
    • Year and Date
      2016-06-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] 静脈血栓塞栓症発症危険要因の定量分析2015

    • Author(s)
      濱崎直孝
    • Organizer
      第28 回バイオメディカル分析科学シンポジウム
    • Place of Presentation
      長崎大学文教キャンパス
    • Year and Date
      2015-08-22
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] APC凝固制御異常と血栓性素因2014

    • Author(s)
      濱崎 直孝
    • Organizer
      第36回日本血栓止血学会プロテインS研究会シンポジウム
    • Place of Presentation
      大阪国際交流センター
    • Year and Date
      2014-05-30
    • Related Report
      2014 Research-status Report
  • [Presentation] Benefical effect of phospahtidylethanolamine on preventing venous thromboembolism: A rat tail thrombosis model experiment2013

    • Author(s)
      Ayaka Higashijima, Sakiko Mizunoe, Kozue Nakahara, Hiroyuki Kuma, Hinako Hatae and Naotaka Hamasaki
    • Organizer
      IFCC EuroMedlab
    • Place of Presentation
      イタリア・ミラノ
    • Related Report
      2013 Research-status Report
  • [Presentation] 血栓モデルラットを用いた不飽和脂肪酸の血栓症予防効果の検討2013

    • Author(s)
      波多江日成子、隈 博幸、濱崎直孝
    • Organizer
      第35回日本血栓止血学会学術集会
    • Place of Presentation
      山形国際ホテル
    • Related Report
      2013 Research-status Report
  • [Presentation] 静脈血栓塞栓症の予防対策としての新しい検査法

    • Author(s)
      濱崎直孝
    • Organizer
      第27回日本臨床検査自動化学会春季セミナー
    • Place of Presentation
      くまもと森都心プラザ
    • Related Report
      2013 Research-status Report
    • Invited
  • [Book] 医療の羅針盤 臨床検査を語る2014

    • Author(s)
      濱崎直孝、上平憲
    • Total Pages
      125
    • Publisher
      長崎文献社
    • Related Report
      2013 Research-status Report
  • [Remarks] 長崎国際大学薬学部臨床検査学研究室

    • URL

      http://www.niu.ac.jp/~pharm1/lab/cclm/thrombosis.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 長崎国際大学薬学部臨床検査学研究室ホームページ

    • URL

      http://www.niu.ac.jp/~pharm1/lab/cclm/thrombosis.html

    • Related Report
      2014 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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