Studies on thrombophilia -deficiency and mutation of protein S-
| Project/Area Number |
25460398
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Nagasaki International University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KUMA Hiroyuki 長崎国際大学, 薬学部, 准教授 (40435136)
HATAE Hinako 長崎国際大学, 薬学部, 助教 (00551582)
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| Research Collaborator |
TSUDA Tomohide
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | プロテインS / 血栓性素因 / 深部静脈血栓症 / プロテインS比活性 / 比活性 / プロテインＳ |
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| Outline of Final Research Achievements |
In this study, we developed new assay system to be an effective screening tool for protein S (PS) deficiency. This assay named “PS specific activity test”was covered by insurance last year. When our new assay of PS specific activity was performed in blood samples of thrombosis patients, all of patients with low PS specific activity have genetic mutation. These data clearly show that protein S deficiency is one of major Japanese thrombophilia.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Multianalyte Conventional Reference Material (MacRM): A Useful Tool for Nationwide Standardization of Laboratory Measurements for Medical Care-A Model Study in Japan2016
Author(s)
Shinohara K, Hamasaki N, Takagi Y, Yatomi Y, Kikuchi H, Hosogaya S, Kawai Y, Miyachi H, Kaneko K, Miyajima Y, Matsumoto H, Yamamoto Y, Iwagami M, Osawa S, Umeda M, Koide H, Yoshimura D, Kato H
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Journal Title
Clinical Chemistry
Volume: 62
Issue: 2
Pages: 392-406
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Crystal structure of the anion exchanger domain of human erythrocyte band 32015
Author(s)
Arakawa T, Kobayashi-Yurugi T, Alguel Y, Iwanari H, Hatae H, Iwata M, Abe Y, Hino T, Ikeda-Suno C, Kuma H, Kang D, Murata T, Hamakubo T, Cameron AD, Kobayashi T, Hamasaki N, Iwata S
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Journal Title
Science
Volume: 350
Issue: 6261
Pages: 680-684
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Phosphoenolpyruvate, a glycolytic intermediate, as a cytoprotectant and antioxidant in ex-vivo cold-preserved mouse liver: a potential application for organ preservation.2013
Author(s)
Kondo Y, Ishitsuka Y, Kadowaki D, Fukumoto Y, Miyamoto Y, Irikura M, Hirata S, Sato K, Maruyama T, Hamasaki N, Irie T
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Journal Title
J Pharm Pharmacol
Volume: 65(3)
Issue: 3
Pages: 390-401
DOI
Related Report
Peer Reviewed
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[Journal Article] Comparative effects of phosphoenolpyruvate (PEP), a glycolytic intermediate, as an organ preservation agent with glucose and N-acetylcysteine against organ damage during cold storage of mouse liver and kidney2013
Author(s)
Ishitsuka Y, Fukumoto Y, Kondo Y, Irikura M, Kadowaki D, Narita Y, Hirata S, Moriuchi H, Maruyama T, Hamasak N, Irie T
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Journal Title
ISRN Pharmacology
Volume: 2013
Pages: 375825-375825
DOI
Related Report
Peer Reviewed
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