Prognostic significance of immune microenvironment in cancer.

• Project/Area Number: 25460412
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: The University of Tokyo
• Principal Investigator: Morikawa Teppei 東京大学, 医学部附属病院, 講師 (80451772)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 癌免疫微小環境 / 免疫組織化学 / 画像解析 / 生存解析 / 癌 / 免疫微小環境 / リンパ球浸潤 / 予後因子 / 胃癌 / 尿路上皮癌 / 腫瘍関連マクロファージ / 癌間質 / 予後 / マクロファージ

Outline of Final Research Achievements

We examined the association between immune-microenvironment status and prognosis in upper and lower tract urothelial carcinoma and gastric carcinoma. In upper and lower tract urothelial carcinoma, high-infiltration of CD204-positive tumor-associated macrophages was significantly correlated with poorer patient outcome. In addition, CD204/CD8 ratio was a strong prognostic factor in bladder cancer. High-infiltration of CD204-positive macrophages was also significantly correlated with poorer patient outcome in gastric carcinoma. In conclusion, we have found that immune-microenvironment status, especially the density of CD204-positive macrophages, may serve as a useful prognostic factor in multiple types of cancer.

Research Products

• [Journal Article] MAGE-A expression, immune microenvironment, and prognosis in upper urinary tract carcinoma. (2016)
  • Author(s): Makise N, Morikawa T, Nakagawa T, Ichimura T, Kawai T, Matsushita H, Kakimi K, Kume H, Homma Y, Fukayama M.
  • Journal Title: Human Pathology Volume: 50 Pages: 62-69
  • DOI: 10.1016/j.humpath.2015.11.007
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] In Epstein-Barr virus-associated gastric carcinoma a high density of CD66b-positive tumor-associated neutrophils is associated with intestinal-type histology and low frequency of lymph node metastasis. (2016)
  • Author(s): Abe H, Morikawa T, Saito R, Yamashita H, Seto Y, Fukayama M.
  • Journal Title: Virchows Arch Volume: 印刷中
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Squamous differentiation and prognosis in upper urinary tract urothelial carcinoma. (2015)
  • Author(s): Makise N, Morikawa T, Kawai T, Nakagawa T, Kume H, Homma Y, Fukayama M.
  • Journal Title: Int J Clin Exp Pathol Volume: 8 Pages: 7203-7209
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Clinicopathological and prognostic significance of EZH2 expression in upper urinary tract carcinoma. (2014)
  • Author(s): Hayashi A, Morikawa T, Kawai T, Kume H, Ishikawa S, Homma Y, Fukayama M.
  • Journal Title: Virchows Arch Volume: 464 Issue: 4 Pages: 463-471
  • DOI: 10.1007/s00428-014-1541-6
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Prognostic Significance of CD204-Positive Macrophages in Upper Urinary Tract Cancer. (2014)
  • Author(s): Ichimura T, Morikawa T, Kawai T, Nakagawa T, Matsushita H, Kakimi K, Kume H, Ishikawa S, Homma Y, Fukayama M.
  • Journal Title: Ann Surg Oncol. Volume: [Epub ahead of print] Issue: 6 Pages: 2105-12
  • DOI: 10.1245/s10434-014-3503-2
  • Peer Reviewed
• [Presentation] CD66b-Positive Tumor-Associated Neutrophils in Epstein-Barr Virus Associated Gastric Carcinoma: A Comparative Study with CD8-Positive Cytotoxic T-Lymphocytes. (2016)
  • Author(s): Abe H, Morikawa T, Saito R, Yamashita H, Seto Y, Fukayama M.
  • Organizer: United States and Canadian Academy of Pathology, 105th Annual Meeting
  • Place of Presentation: Seattle, USA
  • Year and Date: 2016-03-12
  • Int'l Joint Research
• [Presentation] EBV関連胃癌における好中球浸潤は組織型、深達度、及びリンパ節転移と相関する (2015)
  • Author(s): 阿部 浩幸, 森川 鉄平, 西東 瑠璃, 深山 正久
  • Organizer: 第104回日本病理学会総会
  • Place of Presentation: 名古屋国際会議場(愛知県・名古屋市)
  • Year and Date: 2015-04-30
• [Presentation] MAGE-A Expression, Immune Microenvironment and Prognosis in Upper Urinary Tract Carcinoma (2015)
  • Author(s): Teppei Morikawa, Naohiro Makise, Takashi Ichimura, Masashi Fukayama
  • Organizer: The 104th United States and Canadian Academy of Pathology annual meeting
  • Place of Presentation: ボストン
  • Year and Date: 2015-03-21 – 2015-03-27
• [Presentation] 胃癌におけるCD204陽性細胞密度と予後 (2014)
  • Author(s): 市村 崇, 阿部 浩幸, 森川 鉄平, 牛久 哲男, 山下 裕玄, 石川 俊平, 瀬戸 泰之, 深山 正久
  • Organizer: 第103回日本病理学会総会
  • Place of Presentation: 広島
  • Year and Date: 2014-04-24 – 2014-04-26
• [Presentation] 浸潤性膀胱癌におけるCD8およびCD204陽性細胞密度と予後 (2014)
  • Author(s): 森川 鉄平、市村 崇、川合 剛人、中川 徹、松下 博和、垣見 和宏、久米 春喜、石川 俊平、本間 之夫、深山 正久
  • Organizer: 第103回日本病理学会総会
  • Place of Presentation: 広島国際会議場
• [Book] 病理と臨床 32巻臨時増刊号【免疫組織化学 診断と治療選択の指針】「定量的計測法」 (2014)
  • Author(s): 森川 鉄平、深山 正久
  • Total Pages: 7
  • Publisher: 文光堂
• [Remarks] 東京大学医学部・大学院医学系研究科 人体病理学・病理診断学分野
  • URL: http://pathol.umin.ac.jp/index.shtml