| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
We examined the association between immune-microenvironment status and prognosis in upper and lower tract urothelial carcinoma and gastric carcinoma. In upper and lower tract urothelial carcinoma, high-infiltration of CD204-positive tumor-associated macrophages was significantly correlated with poorer patient outcome. In addition, CD204/CD8 ratio was a strong prognostic factor in bladder cancer. High-infiltration of CD204-positive macrophages was also significantly correlated with poorer patient outcome in gastric carcinoma. In conclusion, we have found that immune-microenvironment status, especially the density of CD204-positive macrophages, may serve as a useful prognostic factor in multiple types of cancer.
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