The elucidation of mutual relations between insulator and methylation in the carcinogenesis and the development to diagnosis.
Project/Area Number |
25460413
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Human pathology
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Research Institution | University of Toyama |
Principal Investigator |
Imura Johji 富山大学, 大学院医学薬学研究部(医学), 教授 (80316554)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | インスレーター / メチル化 / 発がん / CTCF / インスレーター機構 / メチル化異常 / 多段階発癌過程 / 転写機構 / Insulator / methylation / Dnmt / 乳腺 / 多段階発癌 / 乳癌 / 胆道癌 |
Outline of Final Research Achievements |
The methylation of promoter regions and insulator are thought to play a role as the mechanism to relate gene inactivation in the cancer progression of each organ. To investigate the association of both factors, this study was carried out about CCCTC binding factor (CTCF) as one of the later factors and the methylation. The expression of CTCF changed into the cytoplasm from the nucleus of original expression site. The similar tendencies were also recognized in the biliary tract or the endometrial lesion. On the other hand, DNA methyltransferase showed highly expression in the malignancies and it was admitted that the methylation was related with malignant transformation. Furthermore, the expression of Dnmt related to the cytoplasmic expression of CTCF. Because the latter play the leading role according to the tumor development, it was suggested that the former was translocated into the cytoplasm with finishing its role.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] Immunohistochemical analysis of the DNA methyltransferase 3b expression is associated with significant improvements in the discrimination of ulcerative colitis-associated neoplastic lesions.2015
Author(s)
Ueda H, Tanaka H, Ichikawa K, Itabashi M, Kameoka S, Fujii S, Saito N, Kimura R, Shida Y, Fujimori Y, Ohtake S, Tomita S, Imura J, Yasuda Y, Tanigawa N, Uchiyama K, Fujimori T.
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Journal Title
Surg Today
Volume: 43
Pages: 1275-1280
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] IL-22 produced by cancer-associated fibroblasts promotes gastric cancer cell invasion via STAT3 and ERK signaling.2014
Author(s)
Fukui H, Zhang X, Sun C, Hara K, Kikuchi S, Yamasaki T, Kondo T, Tomita T, Oshima T, Watari J, Imura J, Fujimori T, Sasako M, Miwa H
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Journal Title
Br J Cancer
Volume: 111
Issue: 4
Pages: 183-490
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Neonatal monosodium glutamate treatment causes obesity, diabetes, and macrovesicular steatohepatitis with liver nodules in DIAR mice.2014
Author(s)
Tsuneyama K, Nishida T, Baba H, Taira S, Fujimoto M, Nomoto K, Hayashi S, Miwa S, Nakajima T, Sutoh M, Oda E, Hokao R, Imura J.
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Journal Title
J Gastroenterol Hepatol.
Volume: 29
Issue: 9
Pages: 1736-1743
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Introduction and utility of liquid-based cytology on aspiration biopsy of peripheral nodular lesions of the lung.2014
Author(s)
Imura J, Abe K, Uchida Y, Shibata M, Tsunematsu K, Sathoh M, Miwa S, Nakajima T, Nomoto K, Hayashi S, Tsuneyama K.
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Journal Title
Oncol lett
Volume: 7
Pages: 669-673
Related Report
Peer Reviewed
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[Journal Article] Taguchi K, Sakata K, Ohashi W, Imaizumi T, Imura J, Hattori Y.2014
Author(s)
Taguchi K, Sakata K, Ohashi W, Imaizumi T, Imura J, Hattori Y.
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Journal Title
J Pharmacol Exp Ther
Volume: 349
Issue: 2
Pages: 199-208
DOI
Related Report
Peer Reviewed
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[Journal Article] Analysis of the anatomic subsites, gender and age in unresectable advanced colorectal carcinomas in Tochigi, Japan suggests a shift in location towards the right side colon in elderly patients treated with cetuximab.2014
Author(s)
Tanaka T, Ichikawa K, Maruoka T, Tomita S, Ueda H, Yamaguchi T, Shida Y, Kato H, Nagata H, Kubota K, Akimoto N, Sakamoto C, Imura J, Arita M, Tanaka H, Okamoto Y, Igarashi Y, Fujimori T..
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Journal Title
Mil Clin Oncol
Volume: 1
Pages: 291-296
Related Report
Peer Reviewed
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[Journal Article] Autoimmune features in metabolic liver disease: a single-center experience and review of the literature.2013
Author(s)
Tsuneyama K, Baba H, Kikuchi K, Nishida T, Nomoto K, Hayashi S, Miwa S, Nakajima T, Nakanishi Y, Masuda S, Terada M, Imura J, Selmi C.
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Journal Title
Clin Rev Allergy Immunol.
Volume: 45(1)
Issue: 1
Pages: 143-8
DOI
Related Report
Peer Reviewed
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