| Project/Area Number |
25460414
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Iwate Medical University (2014-2015)
University of Yamanashi (2013) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
加藤 良平 山梨大学, 総合研究部, 教授 (30152755)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 乳癌 / 神経内分泌腫瘍（NET） / 神経内分泌癌（NEC） / 神経内分泌型非浸潤性乳管癌（NE-DCIS） / 神経内分泌細胞過形成 / 神経内分泌腫瘍 (NET) / 神経内分泌癌 (NEC) / 神経内分泌型非浸潤性乳管癌 (NE-DCIS) |
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| Outline of Final Research Achievements |
We first described widely distributed normal-looking neuroendocrine (NE) cells showing isolated/scattered, clustered and/or circumferential emerging patterns in background tissues of some breast NE carcinoma (B-NEC) including NE ductal carcinoma in situ (NE-DCIS). These novel findings could be regarded as representing “NE cell hyperplasia” relevant to B-NEC development as a precancerous lesion. Furthermore, we reported low-grade B-NEC closely associated with intraductal papilloma and high-grade B-NEC containing conventional in situ ductal carcinoma foci. Thus, we have shown that multiple mechanisms are involved in the development of B-NEC.
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