Elucidation of the developmental mechanisms, proposal of a new classification and the establishment of novel diagnostic and treatment methods for neuroendocrine breast carcinoma
Project/Area Number |
25460414
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Human pathology
|
Research Institution | Iwate Medical University (2014-2015) University of Yamanashi (2013) |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
加藤 良平 山梨大学, 総合研究部, 教授 (30152755)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
|
Keywords | 乳癌 / 神経内分泌腫瘍(NET) / 神経内分泌癌(NEC) / 神経内分泌型非浸潤性乳管癌(NE-DCIS) / 神経内分泌細胞過形成 / 神経内分泌腫瘍 (NET) / 神経内分泌癌 (NEC) / 神経内分泌型非浸潤性乳管癌 (NE-DCIS) |
Outline of Final Research Achievements |
We first described widely distributed normal-looking neuroendocrine (NE) cells showing isolated/scattered, clustered and/or circumferential emerging patterns in background tissues of some breast NE carcinoma (B-NEC) including NE ductal carcinoma in situ (NE-DCIS). These novel findings could be regarded as representing “NE cell hyperplasia” relevant to B-NEC development as a precancerous lesion. Furthermore, we reported low-grade B-NEC closely associated with intraductal papilloma and high-grade B-NEC containing conventional in situ ductal carcinoma foci. Thus, we have shown that multiple mechanisms are involved in the development of B-NEC.
|
Report
(4 results)
Research Products
(117 results)
-
-
-
[Journal Article] Neural cell adhesion molecule (CD56)-positive B cell lymphoma of the urinary bladder2016
Author(s)
Kawasaki T, Suzuki M, Sato A, Yashima-Abo A, Satoh T, Kato R, Kato Y, Obara W, Shimoyama T, Ishida Y, Sugai T
-
Journal Title
J Clin Pathol
Volume: 69
Issue: 1
Pages: 89-92
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
[Journal Article] Clinicopathological and molecular alterations in early gastric cancers with the microsatellite instability-high phenotype2016
Author(s)
Sugimoto R, Sugai T, Habano W, Endoh M, Eizuka M, Yamamoto E, Uesugi N, Ishida K, Kawasaki T, Matsumoto T, Suzuki H.
-
Journal Title
Int J Cancer
Volume: 1
Issue: 7
Pages: 1689-97
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
[Journal Article] Well-differentiated neuroendocrine tumor of the breast with recurrence due to needle tract seeding2015
Author(s)
Kawasaki T, Ishida M, Tada T, Matsuya H, Saitoh M, Sato A, Suzuki M, Sugimoto R, Mue Y, Uesugi N, Ishida K, Ishida K, Ariga H, Ichihara S, Sugai T, Sapino A
-
Journal Title
Virchows Arch
Volume: 466
Issue: 4
Pages: 479-81
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
-
-
-
-
-
-
-
-
[Journal Article] Well-differentiated neuroendocrine tumor of the breast with recurrence due to needle tract seeding.2015
Author(s)
Kawasaki T, Ishida M, Tada T, Matsuya H, Saitoh M, Sato A, Suzuki M, Sugimoto R, Mue Y, Uesugi N, Ishida K, Ishida K, Ariga H, Ichihara S, Sugai T, Sapino A.
-
Journal Title
Virchows Arch
Volume: 466
Pages: 479-81
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
-
[Journal Article] Well-differentiated neuroendocrine tumour of the breast showing peculiar endovascular spread.2014
Author(s)
Kawasaki T, Bussolati G, Marchio C, Castellano I, Daniele L, Molinaro L, Hinata M, Furuya K, Nakagomi H, Oyama T, Tsunoda H, Sugai T, Katoh R, Sapino A.
-
Journal Title
Histopathology
Volume: 64
Pages: 597-600
Related Report
Peer Reviewed / Acknowledgement Compliant
-
[Journal Article] Heterogeneous Immunoreactivity of Emerin, a Nuclear Envelope LEM-domain Protein, in Normal Thyroid Follicles.2014
Author(s)
Jieying W, Kondo T, Yamane T, Nakazawa T, Oishi N, Kawasaki T, Mochizuki K, Dongfeng N, Katoh R.
-
Journal Title
Acta Histochem Cytochem
Volume: 47
Pages: 289-94
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
[Journal Article] Renal cell carcinoma treated with stereotactic radiotherapy with histological change confirmed on autopsy: a case report.2014
Author(s)
Onishi H, Kawasaki T, Zakoji H, Yoshida T, Komiyama T, Kuriyama K, Araya M, Saito R, Aoki S, Maehata Y, Tominaga L, Marino K, Watanabe I, Oguri M, Araki T, Enomoto N, Takeda M, Katoh R.
-
Journal Title
BMC Res Notes
Volume: 26
Pages: 270-270
Related Report
Peer Reviewed
-
-
[Journal Article] 【大腸LSTの診断と意義-拡大内視鏡を中心に】 大腸LSTの肉眼亜型分類に基づいた臨床病理学的および分子病理学的検討2014
Author(s)
上杉 憲幸, 川崎 啓祐, 梁井 俊一, 永塚 真, 荒川 典之, 杉本 亮, 小坂 崇, 石田 和之, 川崎 朋範, 松本 主之, 菅井 有
-
Journal Title
胃と腸
Volume: 49
Pages: 1732-1747
Related Report
Peer Reviewed
-
[Journal Article] Small-cell carcinoma of the breast with squamous differentiation.2013
Author(s)
Kawasaki T, Bussolati G, Castellano I, Marchio C, Daniele L, Molinaro L, Kondo T, Katoh R, Inoue S, Fujii H, Sugai T, Sapino A.
-
Journal Title
Histopathology
Volume: 63
Pages: 739-741
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] High prevalence of solid papillary carcinoma with neuroendocrine differentiation in breast lesions detected by the clinical symptom of bloody nipple discharge2015
Author(s)
Kawasaki T, Sato A, Saitoh M, Matsui Y, Ishida K, Kashiwaba M, Ichihara S, Yagata H, Yamauchi H, Sugai T, Sapino A
Organizer
27th European Congress of Pathology (ECP)
Place of Presentation
Sava Centar (Beograd, Serbia)
Year and Date
2015-09-05
Related Report
Int'l Joint Research
-
[Presentation] Microinvasive neuroendocrine carcinoma arising from central papilloma of the breast2015
Author(s)
Kawasaki T, Sato A, Saitoh M, Tsunoda H, Moritani S, Ichihara S, Yamauchi H, Uesugi N, Sugai T, Sapino A, Katoh R
Organizer
27th European Congress of Pathology (ECP)
Place of Presentation
Sava Centar (Beograd, Serbia)
Year and Date
2015-09-05
Related Report
Int'l Joint Research
-
[Presentation] Massive myoepithelial hyperplasia (myoepitheliosis) with lumpy deposits of basement membrane material closely associated with apocrine adenosis and ductal carcinoma in situ of the breast2015
Author(s)
Kawasaki T, Sato A, Oyama T, Nakagomi H, Furuya K, Inoue M, Moriya T, Tsunoda H, Ichihara S, Sugai T, Katoh R
Organizer
27th European Congress of Pathology (ECP)
Place of Presentation
Sava Centar (Beograd, Serbia)
Year and Date
2015-09-05
Related Report
Int'l Joint Research
-
[Presentation] Well-differentiated neuroendocrine tumor of the breast with recurrence due to needle tract seeding2015
Author(s)
Sato A, Kawasaki T, Ishida M, Tada T, Matsuya H, Ichihara S, Tomabechi M, Ariga H, Suzuki M, Sugai T, Sapino A
Organizer
27th European Congress of Pathology (ECP)
Place of Presentation
Sava Centar (Beograd, Serbia)
Year and Date
2015-09-05
Related Report
Int'l Joint Research
-
[Presentation] Cytological features of pleomorphic/necrotic lobular carcinoma in situ of the breast detected by screening mammography2015
Author(s)
Sato A, Kawasaki T, Yuminamochi T, Ishii Y, Nakazawa K, Sato S, Yamada N, Ambo J, Moritani S, Ichihara S, Sugai T
Organizer
27th European Congress of Pathology (ECP)
Place of Presentation
Sava Centar (Beograd, Serbia)
Year and Date
2015-09-05
Related Report
Int'l Joint Research
-
[Presentation] Glycogen-rich clear cell carcinoma of the breast showing carcinomatous lymphangiosis and extremely aggressive clinical behavior2015
Author(s)
Sato A, Kawasaki T, Mue Y, Ishida K, Komatsu H, Kashiwaba M, Tomabechi M, Ariga H, Moritani S, Ichihara S, Sugai T
Organizer
27th European Congress of Pathology (ECP)
Place of Presentation
Sava Centar (Beograd, Serbia)
Year and Date
2015-09-05
Related Report
Int'l Joint Research
-
-
-
-
-
-
[Presentation] Massive myoepitheliosis with lumpy deposits of basement membrane material related to apocrine lesion_2015
Author(s)
川崎朋範, 中込博, 古屋一茂, 井上正行, 中山裕子, 小山敏雄, 石田和茂, 小松英明, 柏葉匡寛, 市原周, 森谷卓也, 山内英子, 菅井有
Organizer
第23回日本乳癌学会学術総会
Place of Presentation
東京国際フォーラム(東京)
Year and Date
2015-07-02
Related Report
-
-
[Presentation] 当科におけるPertuzumabの使用経験2015
Author(s)
小松英明, 柏葉匡寛, 石田和茂, 川岸涼子, 松井雄介, 大槻英恵, 上杉憲幸, 川崎朋範, 菅井有, 若林剛
Organizer
第23回日本乳癌学会学術総会
Place of Presentation
東京国際フォーラム(東京)
Year and Date
2015-07-02
Related Report
-
[Presentation] 当科の非浸潤性乳管癌におけるセンチネルリンパ節生検の検討2015
Author(s)
石田和茂, 柏葉匡寛, 大槻花恵, 松井雄介, 川岸涼子, 小松英明, 稲葉亨, 上杉憲幸, 石田和之, 川崎朋範, 菅井有, 若林剛
Organizer
第23回日本乳癌学会学術総会
Place of Presentation
東京国際フォーラム(東京)
Year and Date
2015-07-02
Related Report
-
-
-
-
-
-
-
-
[Presentation] 乳腺腺様嚢胞癌の臨床病理学的検討2015
Author(s)
中井登紀子, 内山智子, 森田剛平, 高野将人, 武田麻衣子, 畠山金太, 川崎朋範, 森谷鈴子, 市原周, 大林千穂
Organizer
第104回日本病理学会総会
Place of Presentation
名古屋国際会議場(名古屋市)
Year and Date
2015-04-30
Related Report
-
-
-
-
-
-
-
-
-
-
[Presentation] 貴重な分子解析ができた胃癌症例の1例2015
Author(s)
荒川典之, 永塚真, 高橋弥生, 杉本亮, 小坂崇, 無江良晴, 上杉憲幸, 川崎朋範, 石田和之, 菅井有
Organizer
第104回日本病理学会総会
Place of Presentation
名古屋国際会議場(名古屋市)
Year and Date
2015-04-30
Related Report
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Neuroendocrine cell hyperplasia of the breast - potential precancerous lesion of mammary neuroendocrine carcinoma2014
Author(s)
Kawasaki T, Kashiwaba M, Suzuki M, Mue Y, Sugimoto R, Yamada N, Uesugi N, Ishida K, Ishida K, Komatsu H, Sugai T
Organizer
第60回日本病理学会 秋期特別総会
Place of Presentation
国立劇場おきなわ(沖縄県浦添市)
Year and Date
2014-11-20 – 2014-11-21
Related Report
-
-
-
-
[Presentation] Neuroendocrine carcinoma (NEC) of the breast - clinicopathological study of 90 NEC cases in conjunction with 1522 non-NEC cases.2014
Author(s)
Kawasaki T, Suzuki M, Kosaka T, Sugimoto R, Mue Y, Uesugi N, Ishida K, Katoh R, Sugai T, Sapino A.
Organizer
26th European Congress of Pathology (Virchows Arch)
Place of Presentation
ExCeL London Exhibition and Convention Centre (London, United Kingdom)
Year and Date
2014-08-30 – 2014-09-03
Related Report
-
[Presentation] Neuroendocrine ductal carcinoma in situ, comedo type, of the breast detected by screening mammography - a potentially pre-invasive counterpart of high-grade neuroendocrine tumors.2014
Author(s)
Kawasaki T, Bussolati G, Suzuki M, Kosaka T, Sugimoto R, Mue Y, Uesugi N, Ishida K, Katoh R, Sugai T, Sapino A.
Organizer
26th European Congress of Pathology (Virchows Arch)
Place of Presentation
ExCeL London Exhibition and Convention Centre (London, United Kingdom)
Year and Date
2014-08-30 – 2014-09-03
Related Report
-
-
-
-
-
-
-
-
-
-
[Presentation] Breast schistosomiasis japonica.2013
Author(s)
Kawasaki T, Bussolati G, Castellano I, Marchio C, Daniele L, Molinaro L, Katoh R, Sapino A.
Organizer
25th European Congress of Pathology (Virchows Arch)
Place of Presentation
Lisbon Congress Centre (Lisbon, Portugal)
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-