Molecular mechanisms of serrated pathway in colorectal cancer pathogenesis and their application to diagnosis

• Project/Area Number: 25460416
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Hiroshima University
• Principal Investigator: Sentani Kazuhiro 広島大学, 医歯薬保健学研究院(医), 講師 (30508164)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 大腸発癌 / Fukutin / SPC18 / BST2 / 大腸癌 / 前癌病変 / 予後不良 / βカテニン / 胃癌 / 網羅的遺伝子発現解析 / 大腸鋸歯状病変 / 浸潤先進部

Outline of Final Research Achievements

Expression of SPC18 and BST2, identified from the gene databases of gastrointestinal cancer, were observed in about half of colorectal cancer (CRC). There was a significant correlation of their expressions with high stage and poor prognosis, and both molecules promoted the ability of proliferation and invasion in CRC. These molecules expressed more frequently in CRC and precancerous lesions of classical pathway than those in serrated pathway. These results indicated that SPC18 and BST2 might be a crucial molecules involving in the differences of both pathways.
In addition, we clarified the significance of MMP-7, lamininγ2 and EGFR at the invasive front of gastric cancer and their association with tumor aggressiveness.

Research Products

• [Journal Article] Mouse model of proximal colon-specific tumorigenesis driven by microsatellite instability-induced Cre-mediated inactivation of Apc and activation of Kras. (2016)
  • Author(s): Kawaguchi Y, Hinoi T, Saito Y, Adachi T, Miguchi M, Niitsu H, Sasada T, Shimomura M, Egi H, Oka S, Tanaka S, Chayama K, Sentani K, Oue N, Yasui W, Ohdan H.
  • Journal Title: J Gastroenterol. Volume: 51 Issue: 5 Pages: 447-457
  • DOI: 10.1007/s00535-015-1121-9
  • Peer Reviewed / Open Access
• [Journal Article] Fukutin, identified by the Escherichia coli ampicillin secretion trap (CAST) method, participates in tumor progression in gastric cancer. (2016)
  • Author(s): Oo HZ, Sentani K, Mukai S, Hattori T, Shinmei S, Goto K, Sakamoto N, Naito Y, Anami K, Trang PT, Yanagihara K, Oue N, Yasui W.
  • Journal Title: Gastric Cancer Volume: 19 Issue: 2 Pages: 443-452
  • DOI: 10.1007/s10120-015-0511-2
  • NAID: 40020835493
  • Peer Reviewed / Open Access
• [Journal Article] Regression of Cecal MALT Lymphoma after Antibiotic Treatment in a Patient with <i>Helicobacter pylori</i> Infection (2016)
  • Author(s): Yuge R, Kitadai Y, Tanaka S, Uraoka N, Sentani K, Yasui W, Chayama K.
  • Journal Title: Internal Medicine Volume: 55 Issue: 2 Pages: 135-139
  • DOI: 10.2169/internalmedicine.55.5937
  • NAID: 130005119765
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access
• [Journal Article] A case of tubulocystic carcinoma of the kidney with aggressive features. (2016)
  • Author(s): Maeda Y, Goto K, Honda Y, Kuroda N, Sentani K, Yasui W, Hayashi T, Teishima J, Matsubara A, Nakamura Y, Toyota N, Iida M, Awai K.
  • Journal Title: Jpn J Radiol. Volume: 34 Issue: 4 Pages: 307-311
  • DOI: 10.1007/s11604-016-0525-7
  • NAID: 50009787736
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] ALKR1275Q perturbs extracellular matrix, enhances cell invasion and leads to the development of neuroblastoma in cooperation with MYCN. (2016)
  • Author(s): Ueda T, Nakata Y, Yamasaki N, Oda H, Sentani K, Kanai A, Onishi N, Ikeda K, Sera Y, Honda ZI, Tanaka K, Sata M, Ogawa S, Yasui W, Saya H, Takita J, Honda H.
  • Journal Title: Oncogene. Volume: 無 Issue: 34 Pages: 4447-4458
  • DOI: 10.1038/onc.2015.519
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] High-grade epithelial-myoepithelial carcinoma of the parotid gland with mucous cell differentiation. (2015)
  • Author(s): Sentani K, Ogawa I, Uraoka N, Ikeda M, Hayashi N, Hattori T, Hattori Y, Oue N, Takata T, Yasui W.
  • Journal Title: Pathol Int. Volume: 65 Issue: 9 Pages: 490-494
  • DOI: 10.1111/pin.12315
  • Peer Reviewed / Open Access
• [Journal Article] T-staging of urothelial carcinomas of the ureter by CT: A preliminary study of new diagnostic criteria proposed for differentiating between T2 or lower and T3 or higher (2015)
  • Author(s): Yukiko Honda
  • Journal Title: Am J Roentgenol Volume: 204 Issue: 4 Pages: 792-797
  • DOI: 10.2214/ajr.14.13167
  • Peer Reviewed
• [Journal Article] Clinicopathologic and molecular characteristics of gastric cancer showing gastric and intestinal mucin phenotype (2015)
  • Author(s): Oue N, Sentani K, Sakamoto N, Yasui W
  • Journal Title: Cancer Sci Volume: 106 Issue: 8 Pages: 951-958
  • DOI: 10.1111/cas.12706
  • Peer Reviewed / Open Access
• [Journal Article] Characteristic miR-24 Expression in Gastric Cancers among Atomic Bomb Survivors. (2015)
  • Author(s): Naito Y, Oue N, Pham TT, Yamamoto M, Fujihara M, Ishida T, Mukai S, Sentani K, Sakamoto N, Hida E, Sasaki H, Yasui W.
  • Journal Title: Pathobiology Volume: 82 Issue: 2 Pages: 68-75
  • DOI: 10.1159/000398809
  • Peer Reviewed
• [Journal Article] New molecular staging with G-factor supplements TNM classification in gastric cancer: A multicenter collaborative research by the Japanese Society for Gastroenterological Carcinogenesis G-Project committee (2015)
  • Author(s): Sawada T, Yashiro M, Sentani K, Oue N, Yasui W, Miyazaki K, Kai K, Fushida S, Fujimura T, Ohira M, Kakeji Y, Natsugoe S, Shirabe K, Nomura S, Shimada Y, Tomita N, Hirakawa K, Maehara Y
  • Journal Title: Gastric Cancer Volume: 18 Issue: 1 Pages: 119-128
  • DOI: 10.1007/s10120-014-0338-2
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Aberrant DNA methylation of DLX4 and SIM1 is a predictive marker for disease progression of uterine cervical low-grade squamous intraepithelial lesion. (2015)
  • Author(s): Sakane J, Taniyama K, Miyamoto K, Saito A, Kuraoka K, Nishimura T, Sentani K, Oue N, Yasui W.
  • Journal Title: Diagn Cytopathol. Volume: 43 Issue: 6 Pages: 462-470
  • DOI: 10.1002/dc.23256
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The Potential Role of Inflammation Associated with Interaction between Osteopontin and CD44 in a Case of Pulmonary Tumor Thrombotic Microangiopathy Caused by Breast Cancer (2015)
  • Author(s): Higashi A, Dohi Y, Uraoka N, Sentani K, Uga S, Kinoshita H, Sada Y, Kitagawa T, Hidaka T, Kurisu S, Yamamoto H, Yasui W, Kihara Y.
  • Journal Title: Internal Medicine Volume: 54 Issue: 22 Pages: 2877-2880
  • DOI: 10.2169/internalmedicine.54.4749
  • NAID: 130005108845
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access
• [Journal Article] Significance of miR-148a in Colorectal Neoplasia: Downregulation of miR-148a Contributes to the Carcinogenesis and Cell Invasion of Colorectal Cancer. (2015)
  • Author(s): Hibino Y, Sakamoto N, Naito Y, Goto K, Oo HZ, Sentani K, Hinoi T, Ohdan H, Oue N, Yasui W.
  • Journal Title: Pathobiology Volume: 82 Issue: 5 Pages: 233-241
  • DOI: 10.1159/000438826
  • Peer Reviewed
• [Journal Article] Chlorinated Water Modulates the Development of Colorectal Tumors with Chromosomal Instability and Gut Microbiota in Apc-Deficient Mice. (2015)
  • Author(s): Sasada T, Hinoi T, Saito Y, Adachi T, Takakura Y, Kawaguchi Y, Sotomaru Y, Sentani K, Oue N, Yasui W, Ohdan H.
  • Journal Title: PLoS One. Volume: 10 Issue: 7 Pages: e0132435-e0132435
  • DOI: 10.1371/journal.pone.0132435
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The relationship between inflammation and neoangiogenesis of epicardial adipose tissue and coronary atherosclerosis based on computed tomography analysis. (2015)
  • Author(s): Kitagawa T, Yamamoto H, Sentani K, Takahashi S, Tsushima H, Senoo A, Yasui W, Sueda T, Kihara Y.
  • Journal Title: Atherosclerosis. Volume: 243(1) Issue: 1 Pages: 293-9
  • DOI: 10.1016/j.atherosclerosis.2015.09.013
  • Peer Reviewed / Open Access
• [Journal Article] Data set for volumetric and pathological findings of epicardial adipose tissue. (2015)
  • Author(s): Kitagawa T, Yamamoto H, Sentani K, Takahashi S, Tsushima H, Senoo A, Yasui W, Sueda T, Kihara Y.
  • Journal Title: Data Brief. Volume: 5 Pages: 337-41
  • DOI: 10.1016/j.dib.2015.09.016
  • Peer Reviewed / Open Access
• [Journal Article] The transcribed-ultra conserved regions in prostate and gastric cancer: DNA hypermethylation and microRNA-associated regulation. (2015)
  • Author(s): Keisuke Goto, Sho Ishikawa,Ririno Honma, Keiji Tanimoto, Naoya Sakamoto,Kazuhiro Sentani, Naohide Oue, Jun Teishima, Akio Matsubara and Wataru Yasui.
  • Journal Title: Oncogene Volume: 1 Issue: 27 Pages: 1-1
  • DOI: 10.1038/onc.2015.445
  • Peer Reviewed / Open Access
• [Journal Article] TSPAN8, identified by Escherichia coli ampicillin secretion trap, is associated with cell growth and invasion in gastric cancer (2015)
  • Author(s): Katsuhiro Anami, Naohide Oue, Tsuyoshi Noguchi, Naoya Sakamoto, Kazuhiro Sentani, Tetsutaro Hayashi, Yutaka Naito, Htoo Zarni Oo, Wataru Yasui
  • Journal Title: Gastric Cancer Volume: ahead of print Issue: 2 Pages: 370-380
  • DOI: 10.1007/s10120-015-0478-z
  • Peer Reviewed / Open Access
• [Journal Article] Alpha-fetoprotein-producing clear cell carcinoma of the gallbladder with neuroendocrine differentiation. (2014)
  • Author(s): Sentani K, Uraoka N, Oue N, Yasui W.
  • Journal Title: Med Mol Morphol. Volume: 47 Issue: 1 Pages: 54-56
  • DOI: 10.1007/s00795-013-0049-5
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] NRD1, which encodes nardilysin protein, promotes esophageal cancer cell invasion through induction of MMP2 and MMP3 expression (2014)
  • Author(s): Naohiro Uraoka, Naohide Oue, Naoya Sakamoto, Kazuhiro Sentani, Htoo Zarni Oo, Yutaka Naito, Tsuyoshi Noguchi, Wataru Yasui
  • Journal Title: Cancer Science Volume: 105 Issue: 1 Pages: 134-140
  • DOI: 10.1111/cas.12316
  • Peer Reviewed / Open Access
• [Journal Article] MicroRNA-143 regulates collagen type III expression in stromal fibroblasts of scirrhous typoe gastric cancer (2014)
  • Author(s): Yutaka Naito, Naoya Sakamoto, Naohide Oue, Masakazu Yashiro, Kazuhiro Sentani, Kazuyoshi Yanagihara, Kosei Hirakawa, Wataru Yasui
  • Journal Title: Cancer Science Volume: 105 Issue: 2 Pages: 228-235
  • DOI: 10.1111/cas.12329
  • Peer Reviewed / Open Access
• [Journal Article] MiR-148a is down-regulated in gastric cancer, targets MMP7 and indicates tumor invasiveness and poor prognosis (2014)
  • Author(s): Naoya Sakamoto, Yutaka Naito, Naohide Oue, Kazuhiro Sentani, Naohiro Uraoka, Htoo Zarni Oo, Kazuyoshi Yanagihara, Kazuhiko Aoyagi, Hiroki Sasaki, Wataru Yasui
  • Journal Title: Cancer Science Volume: 105 Issue: 2 Pages: 236-243
  • DOI: 10.1111/cas.12330
  • Peer Reviewed / Open Access
• [Journal Article] Identification of novel transmembrane proteins in scirrhous type gastric cancer by Escherichia coli ampicillin trap (CAST) method: TM9SF3 participates in tumor invasion and serves as a prognostic factor (2014)
  • Author(s): Oo HZ, Sentani K, Sakamoto N, Anami K, Naito Y, Oshima T, Yanagihara K, Oue N, Yasui W
  • Journal Title: Pathobiology Volume: 81 Issue: 3 Pages: 138-148
  • DOI: 10.1159/000357821
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Overexpression of ZDHHC14 promotes migration and invasion of scirrhous type gastric cancer (2014)
  • Author(s): Htoo Zarni Oo, Kazuhiro Sentani, Naoya Sakamoto, Katsuhiro Anami, Yutaka Naito, Naohiro Uraoka, Takashi Oshima, Kazuyoshi Yanagihara, Naohide Oue, Wataru Yasui
  • Journal Title: Oncology Reports Volume: 32 Issue: 1 Pages: 403-410
  • DOI: 10.3892/or.2014.3166
  • Peer Reviewed
• [Journal Article] Identification of PRL1 as a novel diagnostic and therapeutic target for castration-resistant prostate cancer by the Escherichia coli ampicillin secretion trap (CAST) method (2014)
  • Author(s): Shunsuke Shinmei, Kazuhiro Sentani, Tetsutaro Hayashi, Naoya Sakamoto, Keisuke Goto, Htoo Zarni Oo, Yutaka Naito, Jun Teishima, Akio Matsubara, Naohide Oue, Hiroki Kuniyasu, Wataru Yasui
  • Journal Title: Urologic Oncology Volume: 32 Issue: 6 Pages: 769-778
  • DOI: 10.1016/j.urolonc.2014.03.007
  • Peer Reviewed / Open Access
• [Journal Article] MicroRNA-145 is a potential prognostic factor of scirrhous type gastric cancer (2014)
  • Author(s): Yutaka Naito, Kyohei Yasuno, Hiroko Tagawa, Naoya Sakamoto, Naohide Oue, Masakazu Yashiro, Kazuhiro Sentani, Keisuke Goto, Shunsuke Shinmei, Htoo Zarni Oo, Kazuyoshi Yanagihara, Kosei Hirakawa, Wataru Yasui
  • Journal Title: Oncology Reports Volume: 32 Issue: 4 Pages: 1720-1726
  • DOI: 10.3892/or.2014.3333
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Expression of novel biomarkers identified by Escherichia coli ampicillin secretion trap: Oligophrenin-1 is associated with cell adhesion and migration in prostate cancer (2014)
  • Author(s): Goto K, Oue N, Hayashi T, Shinmei S, Sakamoto N, Sentani K, Teishima J, Matsubara A, Yasui W
  • Journal Title: Pathobiology Volume: 81 Issue: 4 Pages: 190-198
  • DOI: 10.1159/000363345
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Identification of Novel Transmembrane Proteins in Scirrhous-Type Gastric Cancer by the Escherichia coli Ampicillin Secretion Trap (CAST) Method: TM9SF3 Participates in Tumor Invasion and Serves as a Prognostic Factor. (2014)
  • Author(s): Oo HZ, Sentani K, Sakamoto N, Anami K, Naito Y, Oshima T, Yanagihara K, Oue N, Yasui W.
  • Journal Title: Pathobiology. Volume: 81 Pages: 138-148
  • Peer Reviewed
• [Journal Article] New molecular staging with G-factor supplements TNM classification in gastric cancer: a multicenter collaborative research by the Japan Society for Gastroenterological Carcinogenesis G-Project committee. (2014)
  • Author(s): Sawada T, Yashiro M, Sentani K, Oue N, Yasui W, Miyazaki K, Kai K, Fushida S, Fujimura T, Ohira M, Kakeji Y, Natsugoe S, Shirabe K, Nomura S, Shimada Y, Tomita N, Hirakawa K, Maehara Y.
  • Journal Title: Gastric Cancer. Volume: In press
  • NAID: 40020580294
  • Peer Reviewed
• [Journal Article] Clinicopathological significance of MMP-7, lamininy2 and EGFR expression at the invasive front of gastric carcinoma (2013)
  • Author(s): Kazuhiro Sentani, Miho Matsuda, Naohide Oue, Naohiro Uraoka, Yutaka Naito, Naoya Sakamoto, Wataru Yasui
  • Journal Title: Gastric Cancer Volume: 17 Issue: 3 Pages: 412-422
  • DOI: 10.1007/s10120-013-0302-6
  • Peer Reviewed / Open Access
• [Journal Article] Signal peptidase complex 18, encodes by SEC11A, contributes to progression via TGF-a secretion in gastric cancer (2013)
  • Author(s): Naohide Oue, Yutaka Naito, Tetsutaro Hayashi, Misato Takigahira, Akiko Kawano-Nagatsuma, Kazuhiro Sentani, Naoya Sakamoto, Htoo Zarni Oo, Naohiro Uraoka, Kazuyoshi Yanagihara, Atsushi Ochiai, Hiroki Sasaki, Wataru Yasui
  • Journal Title: Oncogene Volume: 33 Issue: 30 Pages: 3918-3926
  • DOI: 10.1038/onc.2013.364
  • Peer Reviewed / Open Access
• [Journal Article] The search for secreted proteins in prostate cancer by the Escherichia coli ampicillin secretion trap: expression of NBL1 is highly restricted to the prostate and is related to cancer progression. (2013)
  • Author(s): Hayashi T, Sentani K, Oue N, Ohara S, Teishima J, Anami K, Sakamoto N, Matsubara A, Yasui W.
  • Journal Title: Pathobiology Volume: 80 Issue: 2 Pages: 60-69
  • DOI: 10.1159/000341396
  • Peer Reviewed
• [Journal Article] Expression of olfactomedin 4 and claudin-18 in serrated neoplasia of the colorectum: a characteristic pattern is associated with sessile serrated lesion. (2013)
  • Author(s): Sentani K, Sakamoto N, Shimamoto F, Anami K, Oue N, Yasui W.
  • Journal Title: Histopathology Volume: - Issue: 7 Pages: 1018-1027
  • DOI: 10.1111/his.12099
  • Peer Reviewed
• [Journal Article] Resistin-Like Molecule β Is Abundantly Expressed in Foam Cells and Is Involved in Atherosclerosis Development. (2013)
  • Author(s): Kushiyama A, Sakoda H, Oue N, Okubo M, Nakatsu Y, Ono H, Fukushima T, Kamata H, Nishimura F, Kikuchi T, Fujishiro M, Nishiyama K, Aburatani H, Kushiyama S, Iizuka M, Taki N, Encinas J, Sentani K, Ogonuki N, Ogura A, Kawazu S, Yasui W, Higashi Y, Kurihara H, Katagiri H, Asano T.
  • Journal Title: Arteriosclerosis, Thrombosis, and Vascular Biology Volume: 33 Issue: 8 Pages: 1986-1993
  • DOI: 10.1161/atvbaha.113.301546
  • Peer Reviewed / Open Access
• [Journal Article] Sox9 induction, ectopic Paneth cells, and mitotic spindle axis defects in mouse colon adenomatous epithelium arising from conditional biallelic Apc inactivation. (2013)
  • Author(s): Feng Y, Sentani K, Wiese A, Sands E, Green M, Bommer GT, Cho KR, Fearon ER.
  • Journal Title: Am J Pathol. Volume: 183 Pages: 493-503
  • Peer Reviewed
• [Journal Article] New molecular staging with G-factors (VEGF-C and Reg IV) by supplementing TNM classification in colorectal cancers. (2013)
  • Author(s): Sawada T, Yashiro M, Sentani K, Oue N, Yasui W, Miyazaki K, Kai K, Fujita H, Nakamura K, Maeda K, Kakeji Y, Natsugoe S, Shirabe K, Nomura S, Shimada Y, Tomita N, Hirakawa K, Maehara Y.
  • Journal Title: Oncol Rep. Volume: 30(6) Issue: 6 Pages: 2609-2616
  • DOI: 10.3892/or.2013.2787
  • Peer Reviewed
• [Journal Article] Expression of miR-486 is a potential prognostic factor after nephrectomy in advanced renal cell carcinoma. (2013)
  • Author(s): Goto K, Oue N, Shinmei S, Sentani K, Sakamoto N, Naito Y, Hayashi T, Teishima J, Matsubara A, Yasui W.
  • Journal Title: Mol Clin Oncol. Volume: 1 Pages: 235-240
  • Peer Reviewed
• [Journal Article] MicroRNA-155 is a predictive marker for survival in patients with clear cell renal cell carcinoma. (2012)
  • Author(s): Shinmei S, Sakamoto N, Goto K, Sentani K, Anami K, Hayashi T, Teishima J, Matsubara A, Oue N, Kitadai Y, Yasui W.
  • Journal Title: Int J Urol Volume: - Issue: 5 Pages: 468-477
  • DOI: 10.1111/j.1442-2042.2012.03182.x
  • Peer Reviewed
• [Presentation] CAST法によって同定されたFukutinの胃癌における臨床病理学的意義 (2016)
  • Author(s): 仙谷和弘、Htoo Zarni Oo、今井健晴、大上直秀、安井 弥
  • Organizer: 第88回日本胃癌学会総会
  • Place of Presentation: 別府
  • Year and Date: 2016-03-17
• [Presentation] インテグリンα8β1は筋繊 維芽細胞分化を誘導して組織繊維化を促進する (2015)
  • Author(s): 西道教尚、菅野啓司、杉山晶子、仙谷和弘、安井 弥、横崎恭之
  • Organizer: 第38回日本分子生物学会年会・第88回日本生化学大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-01
• [Presentation] 大腸癌のマウスモデルを用いた新たなTGF-βシグナルターゲット癌関連遺伝子の同定 (2015)
  • Author(s): 三口真司、檜井孝夫、安達智洋、斉藤保文、新津宏明、河内雅年、佐田春樹、伊地知秀明、 田中屋宏爾、北台靖彦、仙谷和弘、大上直秀、安井 弥、大段秀樹
  • Organizer: 第26回日本消化器癌発生学会総会
  • Place of Presentation: 米子
  • Year and Date: 2015-11-19
• [Presentation] KRAS変異型大腸癌自然発生マウスモデルを用いた遺伝子プロファイル解析 (2015)
  • Author(s): 新津宏明、檜井孝夫、川口康夫、仙谷和弘、大上直秀、弓削 亮、齋藤保文、三口真司、河内 雅年、佐田春樹、北台靖彦、安井 弥、大段秀樹
  • Organizer: 第26回日本消化器癌発生学会総会
  • Place of Presentation: 米子
  • Year and Date: 2015-11-19
• [Presentation] CAST法によって同定されたFukutin の胃癌における臨床病理学的意義 (2015)
  • Author(s): 今井健晴、仙谷和弘、Zarni Oo Htoo、大上直秀、安井 弥
  • Organizer: 第26回日本消化器癌発生学会総会
  • Place of Presentation: 米子
  • Year and Date: 2015-11-19
• [Presentation] 胃癌幹細胞およ びスフェロイド形成におけるKIFC1の役割 (2015)
  • Author(s): 大上直秀、向井正一朗、今井健晴、T.B.Pham Trang、仙谷和弘、安井 弥
  • Organizer: 第26回日本消化器癌発生学会総会
  • Place of Presentation: 米子
  • Year and Date: 2015-11-19
• [Presentation] 大腸癌自然発生マウスモデルにおけるシンバイオテイクスが腫瘍形成に及ぼす効果の解析 (2015)
  • Author(s): 齋藤保文、檜井孝夫、安達智洋、惠木浩之、下村 学、三口真司、澤田紘幸、新津宏明、河内 雅年、佐田春樹、仙谷和弘、大上直秀、安井 弥、大段秀樹
  • Organizer: 第26回日本消化器癌発生学会総会
  • Place of Presentation: 米子
  • Year and Date: 2015-11-19
• [Presentation] 大腸がんの新規治療開発に有用な2種類の異なるゲノム不安定性を持つ自然発生型大腸がんマウスモデルの確立 (2015)
  • Author(s): 檜井孝夫、安達智洋、斉藤保文、三口真司、新津宏明、河内雅年、下村 学、北台靖彦、 仙谷和弘、大上直秀、安井 弥、大段秀樹
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
• [Presentation] StageII/III胃癌根治切除後のリスク層別化マーカー検索 (2015)
  • Author(s): 大島 貴、木村弥生、中居祐介、坂巻顕太郎、吉川貴己、宮城洋平、山中正二、利野 靖、 仙谷和弘、大上直秀、安井 弥、今田敏夫、益田宗孝
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
• [Presentation] Transforming growth factor beta receptorII（TGFBR2）変異大腸癌マウスモデルの作製と解析 (2015)
  • Author(s): 三口真司、檜井孝夫、安達智洋、斎藤保文、新津宏明、伊地知秀明、北台靖彦、仙谷和弘、 大上直秀、安井 弥、大段秀樹
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
• [Presentation] 胃癌浸潤先進部 におけるMMP-7、lamininγ2、EGFRの臨床的意義 (2015)
  • Author(s): 仙谷和弘、浦岡直礼、服部拓也、内藤 寛、坂本直也、大上直秀、安井 弥
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
• [Presentation] 大腸癌自然発生マウスモデルにおける新バイオティクス投与が及ぼす影響の解析 (2015)
  • Author(s): 齊藤保文、檜井孝夫、安達智洋、三口真司、新津宏明、河内雅年、仙谷和弘、大上直秀、 安井 弥、大段秀樹
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
• [Presentation] 大腸癌自然発生マウスモデルを用いたKRAS変異型大腸癌の遺伝子発現プロファイル解析 (2015)
  • Author(s): 新津宏明、檜井孝夫、川口康夫、仙谷和弘、大上直秀、安達智洋、齊藤保文、三口真司、河内 雅年、佐田春樹、下村 学、安井 弥、大段秀樹
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
• [Presentation] 胃癌におけるPCDHB9 の発現とその意義 (2015)
  • Author(s): 向井正一朗、大上直秀、後藤景介、仙谷和弘、大段秀樹、安井 弥
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
• [Presentation] KIFC1は胃癌細胞のスフェ ロイド形成に重要である (2015)
  • Author(s): 大上直秀、向井正一朗、Pham T.B Trang、仙谷和弘、安井 弥
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
• [Presentation] 胃腺 腫の長期経過に関する検討 (2015)
  • Author(s): 谷山大樹、谷山清己、倉岡和矢、在津潤一、齋藤彰久、仙谷和弘、大上直秀、安井 弥
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
• [Presentation] 食道扁平上皮癌におけるPCDHB9の機能解析 (2015)
  • Author(s): 今井健晴、向井正一朗、大上直秀、後藤景介、仙谷和弘、大段秀樹、吉田和弘、安井 弥
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
• [Presentation] 食道扁平上皮 癌におけるolfactomedin4の発現とその臨床病理学的意義 (2015)
  • Author(s): 浦岡直礼、大上直秀、仙谷和弘、向井正一朗、服部拓也、野口 剛、安井 弥
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
• [Presentation] SPC18の大腸癌における発現と機能解析 (2015)
  • Author(s): 服部拓也、大上直秀、仙谷和弘、安井 弥
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
• [Presentation] DNA 異常メチル化解析は子宮頸部重層扁平上皮内低異型度病変の予測に有用である (2015)
  • Author(s): 坂根潤一、谷山清己、宮本和明、齋藤彰久、仙谷和弘、倉岡和矢、大上直秀、安井 弥
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
• [Presentation] 転写超保存領域T-UCRの胃癌・前立腺癌における発現制御機構 (2015)
  • Author(s): 後藤景介、石川 聖、本間りりの、坂本直也、仙谷和弘、大上直秀、亭島 淳、松原昭郎、 安井 弥
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
• [Presentation] 食道癌 におけるBST2の発現 (2015)
  • Author(s): 服部 結、大上直秀、Htoo Zarni Oo、向井正一朗、仙谷和弘、大段秀樹、安井 弥
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
• [Presentation] 膀胱癌における新規HER2標的治療薬T-DM1の有効性 (2015)
  • Author(s): 林哲太郎、Peter C Black、後藤景介、Htoo Zarni Oo、仙谷和弘、亭島 淳、安井 弥、松原 昭郎
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
• [Presentation] 腎細胞癌同所移植モデルにおける分子標的薬の微小環境への効果 (2015)
  • Author(s): 野弘之、亭島 淳、林哲太郎、神明俊輔、永松弘孝、後藤景介、弓削 亮、品川 慶、仙谷 和弘、Peter C Black、北台靖彦、安井 弥、松原昭郎
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
• [Presentation] 膀胱 癌におけるSPC18の発現と機能 (2015)
  • Author(s): 重松慶紀、後藤景介、関野陽平、仙谷和弘、大上直秀、亭島 淳、松原昭郎、安井 弥
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
• [Presentation] 前立腺癌におけるPCDHB9は浸潤に関与する (2015)
  • Author(s): 関野陽平、後藤景介、向井正一朗、重松慶紀、仙谷和弘、大上直秀、亭島 淳、松原昭郎、 安井 弥
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
• [Presentation] SPC18の大腸癌における組織腫瘍マーカーとして の意義 (2015)
  • Author(s): 服部拓也、仙谷和弘、大上直秀、安井 弥
  • Organizer: 第35回分子腫瘍マーカー研究会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-07
• [Presentation] CAST法を用いて同定し たBST2の大腸癌における発現と機能解析 (2015)
  • Author(s): 今井健晴、向井正一朗、大上直秀、仙谷和弘、吉田和弘、安井 弥
  • Organizer: 第34回分子病理研究会
  • Place of Presentation: 神戸
  • Year and Date: 2015-07-25
• [Presentation] 胃癌細胞のスフェ ロイド形成におけるKIFC1の役割 (2015)
  • Author(s): 大上直秀、向井正一朗、Pham T.B. Trang、坂本直也、仙谷和弘、安井 弥
  • Organizer: 第24回日本がん転移学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-07-23
• [Presentation] Function analysis of Signal peptidase complex 18 in colorectal cancer. (2015)
  • Author(s): 服部拓也、仙谷和弘、大上直秀、安井 弥
  • Organizer: 第24回日本がん転移学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-07-23
• [Presentation] Tubulosystic Carcinoma in the Left Kidney with Lymph Node Metastasis : Case Report. (2015)
  • Author(s): Maeda Y, Honda Y, Higaki T, Iida M, Date S, Goto K, Sentani K, Yasui W, Kitano H, Kajiwara M, Matsubara A, Tsuji S, Kuroda N, Matsuura N, Toyota N, Awai
  • Organizer: 第29回日本腹部放射線学会
  • Place of Presentation: 浜松
  • Year and Date: 2015-06-19
• [Presentation] 胃癌浸潤先進部における MMP-7,lamininγ2,EGFRの発現パターンとその臨床病理学的意義 (2015)
  • Author(s): 仙谷和弘、浦岡直礼、向井正一朗、服部拓也、大上直秀、安井 弥
  • Organizer: 第104回日本病理学会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-04-30
• [Presentation] 皮膚balloon cell melanoma の一例 (2015)
  • Author(s): 服部 結、仙谷和弘、浦岡直礼、服部拓也、大上直秀、安井 弥
  • Organizer: 第104回日本病理学会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-04-30
• [Presentation] 非翻訳領域を コードする転写超保存領域T-UCRの胃癌における発現、機能解 (2015)
  • Author(s): 後藤景介、石川 聖、仙谷和弘、大上直秀、亭島 淳、松原昭郎、安井 弥
  • Organizer: 第104回日本病理学会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-04-30
• [Presentation] 胃癌におけるBST2 発現は5-FU感受性と関連がある (2015)
  • Author(s): 向井正一朗、大上直秀、仙谷和弘、Htoo Zarni Oo、大段秀樹、安井 弥
  • Organizer: 第104回日本病理学会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-04-30
• [Presentation] 大腸癌におけるSPC18の機能解析 (2015)
  • Author(s): 服部拓也、大上直秀、仙谷和弘、安井 弥
  • Organizer: 第104回日本病理学会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-04-30
• [Presentation] CAST法を 用いて同定したBST2の食道癌における機能解析 (2015)
  • Author(s): 立本淑子、向井正一朗、PhamThi Binh Trang、大上直秀、仙谷和弘、安井 弥
  • Organizer: 第104回日本病理学会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-04-30
• [Presentation] 低異型度扁平上皮内病変進 行におけるDNAメチル化異常 (2015)
  • Author(s): 坂根潤一、谷山清己、仙谷和弘、倉岡和矢、大上直秀、安井 弥
  • Organizer: 第104回日本病理学会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-04-30
• [Presentation] CAST 法により同定されたOligophrenin-1の前立腺癌における発現と機能解析 (2015)
  • Author(s): 重松慶紀、後藤景介、林哲太郎、仙谷和弘、大上直秀、亭島 淳、松原昭郎、安井 弥
  • Organizer: 第104回日本病理学会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-04-30
• [Presentation] 前立 腺癌における転写超保存領域T-UCRの発現調節機構 (2015)
  • Author(s): 関野陽平、後藤景介、石川 聖、仙谷和弘、大上直秀、亭島 淳、松原昭郎、安井 弥
  • Organizer: 第104回日本病理学会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-04-30
• [Presentation] 胃癌における スフェロイド形成関連遺伝子と癌幹細胞との関連 (2015)
  • Author(s): 大上直秀、向井正一朗、Pham T.B Trang、坂本直也、仙谷和弘、安井 弥
  • Organizer: 第104回日本病理学会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-04-30
• [Presentation] Fukutin and CD10 expression in gastric cancer． (2015)
  • Author(s): Trang T.B Pham、Htoo Z.Oo、Kazuhiro Sentani、Naohiro Uraoka、Naohide Oue、Wataru Yasu
  • Organizer: 第104回日本病理学会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-04-30
• [Presentation] 食道扁平上皮癌におけるolfactomedin4発現に関する分子病理学的検討 (2015)
  • Author(s): 浦岡直礼、大上直秀、仙谷和弘、向井正一朗、服部拓也、野口 剛、安井 弥
  • Organizer: 第104回日本病理学会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-04-30
• [Presentation] CTパターンを用いた尿管癌の術前病期診断 (2015)
  • Author(s): 後藤景介、本田有紀子、池田健一郎、小畠浩平、亭島 淳、仙谷和弘、粟井和夫、 安井 弥、松原 昭
  • Organizer: 第103回日本泌尿器科学会総会
  • Place of Presentation: 金沢
  • Year and Date: 2015-04-18
• [Presentation] Fukutin, identified by Escherichia coli Ampicillin Secretion Trap (CAST) method, participates in tumor progression in gastric cancer. (2014)
  • Author(s): Sentani K, Oo HZ, Shinmei S, Mukai S, Sakamoto N, Naito Y, Goto K, Hattori Y, Uraoka N, Oue N and Yasui
  • Organizer: The 5th Taiwan-Japan Conjoint Slide Conference of IAP
  • Place of Presentation: Taipei (台湾)
  • Year and Date: 2014-10-25 – 2014-10-26
• [Presentation] 大腸鋸歯状病変におけるolfactomedin4 とclaudin―18の臨床病理学的意義． (2014)
  • Author(s): 仙谷和弘、坂本直也、嶋本文雄、浦岡直礼、服部拓也、大上直秀、安井 弥
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] 大腸癌におけるSPC18の発現とその意義． (2014)
  • Author(s): 服部拓也、大上直秀、仙谷和弘、安井 弥
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] 大腸癌におけるSPC18の発現とその意義． (2014)
  • Author(s): 服部拓也、大上直秀、仙谷和弘、安井 弥
  • Organizer: 第33回分子病理学研究会
  • Place of Presentation: 蔵王
  • Year and Date: 2014-07-25 – 2014-07-26
• [Presentation] 大腸鋸歯状腫瘍におけるolfactomedin4とclaudin－18の臨床病理学的意義． (2014)
  • Author(s): 仙谷和弘、坂本直也、浦岡直礼、服部拓也、大上直秀、安井 弥
  • Organizer: 第103回日本病理学会総会
  • Place of Presentation: 広島
  • Year and Date: 2014-04-24 – 2014-04-26
• [Presentation] 腸型粘液形質胃癌におけるHOXA10の臨床病理学的意義． (2013)
  • Author(s): 仙谷和弘、大上直秀、内藤 寛、坂本直也、浦岡直礼、安井 弥
  • Organizer: 第102回日本病理学会総会
  • Place of Presentation: 札幌
• [Presentation] 腸型粘液形質胃癌で多く発現するHOXA10は予後良好因子である． (2013)
  • Author(s): 仙谷和弘、大上直秀、内藤 寛、坂本直也、Htoo Zarni Oo、浦岡直礼、青柳一彦、佐々木博己、安井 弥
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Book] 消化管癌におけるマイクロRNA の意義．杉原健一・編、最新臨床大腸癌学 (2015)
  • Author(s): 大上直秀、仙谷和弘、坂本直也、浦岡直礼、安井 弥
  • Total Pages: 711
  • Publisher: 日本臨牀社
• [Book] 胃切除標本の取り扱い．胃外科・術後障害研究会・編 (2014)
  • Author(s): 仙谷和弘、安井 弥
  • Publisher: メジカルビュー社
• [Book] 胃癌の遺伝子異常．外科・術後障害研究会・編 (2014)
  • Author(s): 大上直秀、仙谷和弘、坂本直也、安井 弥
  • Publisher: メジカルビュー社
• [Book] 臨床医のための胃がん病理アトラス (2014)
  • Author(s): 仙谷和弘、若松雄太、Htoo Zarni Oo、安井 弥
  • Publisher: メディカルレビュー社
• [Book] 最新胃癌学 分担（スキルス胃癌の分子生物学と発癌機序p615-618） (2014)
  • Author(s): 仙谷和弘、大上直秀、安井 弥
  • Total Pages: 755
  • Publisher: 日本臨床社
• [Book] 胃外科のすべて 分担（切除標本の取り扱いp92-100） (2014)
  • Author(s): 仙谷和弘、安井 弥
  • Total Pages: 351
  • Publisher: MEDICAL VIEW
• [Remarks] 広島大学大学院医歯薬保健学研究院分子病理学研究室
  • URL: http://home.hiroshima-u.ac.jp/byori1/