Molecular aberrations in intestinal B-cell lymphomas: comprehensive analyses for chromosomal translocations and microRNA expression.
Project/Area Number |
25460418
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Human pathology
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Research Institution | Iwate Medical University (2014-2015) Kyushu University (2013) |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Takayuki 岩手医科大学, 医学部, 教授 (10278955)
ODA Yoshinao 九州大学, 医学研究科(研究院), 教授 (70291515)
HASHIZUME Makoto 九州大学, 医学研究科(研究院), 教授 (90198664)
HIRAHASHI Minako 九州大学, 医学研究科(研究院), 講師 (90529877)
GOTOH Akinobu 兵庫医科大学, 医学部, 教授 (70283885)
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Co-Investigator(Renkei-kenkyūsha) |
TAKESHITA Morishige 福岡大学, 医学部, 教授 (90171636)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | 消化管リンパ腫 / DLBCL / MALTリンパ腫 / FISH / 転座 / IGH / microRNA / 悪性リンパ腫 / 小腸リンパ腫 / 大腸リンパ腫 / 遺伝子 / マイクロRNA / 遺伝子異常 |
Outline of Final Research Achievements |
1) We investigated the significance of chromosomal translocations in small bowel diffuse large B-cell lymphomas (DLBCLs). Translocations involving IGH, BCL6, MYC and BCL2 were detected in 23 (70%), 12 (36%), 8 (24%) and 6 (18%) of 33 cases, respectively. Univariate analyses demonstrated young age, low international prognostic index, IGH-translocations, extra-copies of MALT1/BCL2, and BCL6 immunoexpression to be better overall survival (OS) and progression-free survival (PFS). Cox multivariate analysis revealed IGH-translocations to be an independent prognostic factor for better PFS, but not OS. In conclusion, IGH-translocations are frequent in small bowel DLBCLs, and this translocation may be predictive of favorable prognosis. 2) We comprehensively investigated dysregulation of microRNA expression in representative cases of gastrointestinal MALT lymphoma. Increases and decreases of miroRNAs were identified in 15 and 13 miroRNAs, respectively.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] High expression of intestinal homing receptor CD103 in adult T-cell leukemia/lymphoma, similar to 2 other CD8+ T-cell lymphomas.2016
Author(s)
Ishibashi H, Nimura S, Ishitsuka K, Mihashi Y, Mizoguchi M, Nakamura S, Okamura S, Momosaki S, Aoyagi K, Sakisaka S, Takeshita M.
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Journal Title
Am J Surg Pathol
Volume: 40
Issue: 4
Pages: 462-470
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Nonsurgical treatment for intestinal follicular lymphoma: a retrospective analysis of 43 patients.2013
Author(s)
Nakamura S, Matsumoto T, Ikegami K, Washio E, Esaki M, Kawasaki K, Kurahara K, Hirahashi M, Kitazono T, Hashizume M.
Organizer
Digestive Disease Week 2013/American Gastroenterological Association Institute
Place of Presentation
Orlando, USA
Related Report
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[Presentation] Capsule endoscopy findings in intestinal follicular lymphoma.2013
Author(s)
Washio E, Esaki M, Ikegami K, Kawasaki K, Kurahara K, Kumagae Y, Hirahashi M, Nakamura S, Kitazono T, Matsumoto T.
Organizer
The 21st United European Gastroenterology Week
Place of Presentation
Berlin, Germany
Related Report
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