Clinicopathological and molecular analysis of endometrioid carcinoma based on the expressions of ER, PgR and HER2
Project/Area Number |
25460420
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Human pathology
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Research Institution | Iwate Medical University |
Principal Investigator |
Sugai Tamotsu 岩手医科大学, 医学部, 教授 (20187628)
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Co-Investigator(Renkei-kenkyūsha) |
Sugiyama Tooru 岩手医科大学, 医学部, 教授 (40162903)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 類内膜腺癌 / 遺伝子変異 / KRAS / p53 / PIK3CA / メチル化 / LOH / 子宮内膜癌 / 腫瘍発生 / ER / PgR / HER2 / RAS |
Outline of Final Research Achievements |
The aim of this study was to examine molecular alterations in endometrial cancer (EA) based on the expression of these biomarkers. Samples from 83 EAs were obtained. We classified EAs based on expression of ER, PgR, and HER2. Microsatellite instability (MSI), DNA methylation status, loss of heterozygosity (LOH) and mutations in oncogenes were examined. Types were defined as follows: Type A (ER+ and/or PgR+, HER2-), Type B (ER+ and/or PgR+, HER2+), Type C (ER/PgR-, HER2+), and Type D (ER/PgR-, HER2-). The frequency of PTEN expression in Type C was lower than that in other types. Ki-ras mutations were more frequent in Type C, and PIK3CA mutations were more common in Types A and B. The frequency of LOH-high status in Type C and D was significantly higher than that in Types A and B. Subtypes based on these biomarkers in EA were characterized by each different molecular abnormality.
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Report
(4 results)
Research Products
(171 results)
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[Journal Article] Clinicopathological and molecular alterations in early gastric cancers with the microsatellite instability-high phenotype2016
Author(s)
Sugimoto R, Sugai T, Habano W, Endoh M, Eizuka M, Yamamoto E, Uesugi N, Ishida K, Kawasaki T, Matsumoto T, Suzuki H.
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Journal Title
Int J Cancer
Volume: 1
Issue: 7
Pages: 1689-97
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Endoscopic Findings of Small-Bowel Lesions in Familial Amyloid Polyneuropathy: A Case Report.2016
Author(s)
Asakura K, Yanai S, Nakamura S, Kawaski K, Eizuka M, Ishida K, Sugai T, Ueda M, Yamashita T, Ando Y, Matsumoto T.
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Journal Title
Medicine (Baltimore)
Volume: 95(11)
Issue: 11
Pages: e2896-e2896
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Dabigatran-induced esophagitis: The prevalence and endoscopic characteristics.2016
Author(s)
Toya Y, Nakamura S, Tomita K, Matsuda N, Abe K, Abiko Y, Orikasa S, Akasaka R, Chiba T, Uesugi N, Sugai T, Matsumoto T.
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Journal Title
J Gastroenterol Hepatol
Volume: 31(3)
Issue: 3
Pages: 610-614
DOI
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Peer Reviewed / Open Access
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[Journal Article] Neural cell adhesion molecule (CD56)-positive B cell lymphoma of the urinary bladder2016
Author(s)
Kawasaki T, Suzuki M, Sato A, Yashima-Abo A, Satoh T, Kato R, Kato Y, Obara W, Shimoyama T, Ishida Y, Sugai T
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Journal Title
J Clin Pathol
Volume: 69
Issue: 1
Pages: 89-92
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Chaperone protein l-isoaspartate (d-aspartyl) O-methyltransferase as a novel predictor of poor prognosis in lung adenocarcinoma.2016
Author(s)
Saito H, Yamashita M, Ogasawara M, Yamada N, Niisato M, Tomoyasu M, Deguchi H, Tanita T, Ishida K, Sugai T, Yamauchi K.
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Journal Title
Hum Pathol
Volume: 50
Pages: 1-10
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Analysis of a single-codon E746 deletion in exon 19 of the epidermal growth factor receptor.2016
Author(s)
Ogasawara M, Nakamura Y, Morikawa N, Nitanai H, Moriguchi S, Chiba R, Saito H, Ohta M, Tanita T, Sugai T, Maeyama K, Yamauchi K, Takaoka Y.
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Journal Title
Cancer Chemother Pharmacol
Volume: 77(5)
Issue: 5
Pages: 1019-1029
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Well-differentiated neuroendocrine tumor of the breast with recurrence due to needle tract seeding2015
Author(s)
Kawasaki T, Ishida M, Tada T, Matsuya H, Saitoh M, Sato A, Suzuki M, Sugimoto R, Mue Y, Uesugi N, Ishida K, Ishida K, Ariga H, Ichihara S, Sugai T, Sapino A
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Journal Title
Virchows Arch
Volume: 466
Issue: 4
Pages: 479-81
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Epigenetic silencing of NTSR1 is associated with lateral and noninvasive growth of colorectal tumors2015
Author(s)
Kamimae S, Yamamoto E, Kai M, Niinuma T, Yamano HO, Nojima M, Yoshikawa K, Kimura T, Takagi R, Harada E, Harada T, Maruyama R, Sasaki Y, Tokino T, Shinomura Y, Sugai T, Imai K, Suzuki H
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Journal Title
Oncotarget
Volume: 6
Issue: 30
Pages: 29975-90
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Significance of a white opaque substance under magnifying narrow-band imaging colonoscopy for the diagnosis of colorectal epithelial neoplasms.2015
Author(s)
Kawasaki K, Kurahara K, Yanai S, Oshiro Y, Eizuka M, Uesugi N, Ishida K, Nakamura S, Fuchigami T, Sugai T, Matsumoto T.
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Journal Title
Gastrointest Endosc.
Volume: 82(6)
Issue: 6
Pages: 1097-1104
DOI
Related Report
Peer Reviewed
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[Journal Article] Lymphangiogenic factors are associated with the severity of hypersensitivity pneumonitis2015
Author(s)
Yamashita M, Mouri T, Niisato M, Nitanai H, Kobayashi H, Ogasawara M, Endo R, Konishi K, Sugai T, Sawai T, Yamauchi K
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Journal Title
BMJ Open Respir Res
Volume: 29
Issue: 1
Pages: e000085-e000085
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Non-Islet Cell Tumor Hypoglycemia Is Caused by Big IGF-II in a Patient with a Carcinosarcoma of the Uterus2015
Author(s)
Honma H, Takahashi Y, Matsui M, Satoh T, Fukuda I, Takahashi K, Takebe N, Nagasawa K, Ono M, Sasai T, Kajiwara T, Sugai T, Satoh J, Ishigaki Y.
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Journal Title
Internal Medicine
Volume: 54
Issue: 24
Pages: 3165-3169
DOI
NAID
ISSN
0918-2918, 1349-7235
Related Report
Peer Reviewed / Open Access
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[Journal Article] Well-differentiated neuroendocrine tumour of the breast showing peculiar endovascular spread.2014
Author(s)
Kawasaki T, Gianni B, Caterina M, Isabella C, Daniele,Luca M , Hinata M , Furuya K, Nakagomi H, Oyama T ,Tsunoda H, Sugai T, Katoh R, Anna S
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Journal Title
Histopathology
Volume: 4
Issue: 4
Pages: 597-600
DOI
Related Report
Peer Reviewed
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[Journal Article] Colorectal Carcinomas With CpG Island Methylator Phenotype 1 Frequently Contain Mutations in Chromatin Regulators.2014
Author(s)
Tahara T, Yamamoto E, Madireddi P, Suzuki H, Maruyama R, Chung W, Garriga J, Jelinek J, Yamano HO, Sugai T, Kondo Y, Toyota M, Issa JP, Estécio MR.
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Journal Title
Gastroenterology.
Volume: 146
Pages: 530-538
Related Report
Peer Reviewed
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[Journal Article] Analysis of DNA methylation in bowel lavage fluid for detection of colorectal cancer.2014
Author(s)
Harada T, Yamamoto E, Yamano HO, Nojima M, Maruyama R, Kumegawa K, Ashida M, Yoshikawa K, Kimura T, Harada E, Takagi R, Tanaka Y, Aoki H, Nishizono M, Nakaoka M, Tsuyada A, Niinuma T, Kai M, Shimoda K, Shinomura Y, Sugai T, etc.
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Journal Title
Cancer Prev Res (Phila).
Volume: 7
Pages: 1002-1010
Related Report
Peer Reviewed
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[Journal Article] Standardized uptake value in high uptake area on positron emission tomography with 18F-FRP170 as a hypoxic cell tracer correlates with intratumoral oxygen pressure in glioblastoma2014
Author(s)
Beppu T, Terasaki K, Sasaki T, Fujiwara S, Matsuura H, Ogasawara K, Sera K, Yamada N, Uesugi N, Sugai T, Kudo K, Sasaki M, Ehara S, Iwata R, Takai Y
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Journal Title
Mol Imaging Biol
Volume: 16
Issue: 1
Pages: 127-135
DOI
Related Report
Peer Reviewed
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[Presentation] Massive myoepithelial hyperplasia (myoepitheliosis) with lumpy deposits of basement membrane material closely associated with apocrine adenosis and ductal carcinoma in SITU of the breast.2015
Author(s)
Tomonori K, Ayaka S, Toshio O, Hiroshi N, Kazushige F, Masayuki I, Takuya M, Hiroko T, Shu I, Tamotsu S, Ryohei K
Organizer
27th European Congress of Pathology
Place of Presentation
セルビア
Year and Date
2015-09-05
Related Report
Int'l Joint Research
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[Presentation] Microinvasive neuroendocrine carcinoma arising from central papilloma of the breast.2015
Author(s)
Tomonori K, Ayaka S, Masao S, Hiroko T, Suzuko M, Shu I, Hideko Y, Noriyuki U, Tamotsu S, Anna S, Ryohei K
Organizer
27th European Congress of Pathology
Place of Presentation
セルビア
Year and Date
2015-09-05
Related Report
Int'l Joint Research
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[Presentation] High prevalence of solid papillary carcinoma with neuroendocrine differetiation in breast lesions detedted by the clinical symptom of bloody nipple discharge.2015
Author(s)
Tomonori K, Ayaka S, Masao S, Yusuke M, Kazushige I, Masahiro K, Shu I, Hiroshi Y, Hideko Y, Tamotsu S, Anna S
Organizer
27th European Congress of Pathology
Place of Presentation
セルビア
Year and Date
2015-09-05
Related Report
Int'l Joint Research
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[Presentation] Glycogen-rich clear cell carcinoma of the breast showing carcinomatous lymphangiosis and extremely aggressive clinical behavior.2015
Author(s)
Ayaka S, Tomonori K, Yoshiharu M, Kazushige I, Masahiro K, Makiko T, Hisanori A, Hideaki K, Suzuko M, Shu I, Tamotsu S
Organizer
27th European Congress of Pathology
Place of Presentation
セルビア
Year and Date
2015-09-05
Related Report
Int'l Joint Research
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[Presentation] Well-differentiated neuroendocrine tumour of the breast with recurrence due to needle tract seeding.2015
Author(s)
Ayaka S, Tomonori K, Motoo I, Takashi T, Hideki M, Shu I, Makiko T, Hisanori A, Masamichi S, Tamotsu S, Anna S
Organizer
27th European Congress of Pathology
Place of Presentation
セルビア
Year and Date
2015-09-05
Related Report
Int'l Joint Research
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[Presentation] Cytological features of pleomorphic/necrotic lobular carcinoma in SITU of the breast detected by screening mammography.2015
Author(s)
Ayaka S, Tomonori K, Tsutomu Y, Yoshio I, Kumiko N, Shiori S, Noriyuki Y, Jun-ichi A, Szuko M, Shu I, Tamotsu S
Organizer
27th European Congress of Pathology
Place of Presentation
セルビア
Year and Date
2015-09-05
Related Report
Int'l Joint Research
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[Presentation] Neuroendocrine cell hyperplasia of the breast - potential precancerous lesion of mammary neuroendocrine carcinoma.2014
Author(s)
Kawasaki T, Kashiwaba M, Suzuki M, Mue Y, Sugimoto R, Yamada N, Uesugi N, Ishida Kazuyuki,Ishida Kazushige, Komatsu H, Sugai T
Organizer
第60回日本病理学会秋期特別総会
Place of Presentation
那覇
Year and Date
2014-11-20 – 2014-11-21
Related Report
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[Presentation] Neuroendocrine ductal carcinoma in situ, comedo type of the breast detected by screening mammography: A potentially pre-invasive counterpart of high-grade neroendocrine tumours.2014
Author(s)
Kawasaki T, Bussolati G, Suzuki M, Kosaka T, Sugimoto R, Mue Y, Uesugi N, Ishida K, Katoh R, Sugai T, Sapino A.
Organizer
26th European Congress of Pathology.
Place of Presentation
ロンドン
Year and Date
2014-08-30 – 2014-09-03
Related Report
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