Analysis of microenvironment for vascular and lymphatic invasion at invasive front of colorectal carcinoma
Project/Area Number |
25460423
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Human pathology
|
Research Institution | Toho University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
石川 由起雄 東邦大学, 医学部, 客員教授 (30276894)
|
Project Period (FY) |
2013-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 大腸癌 / bFGF / VEGF / MMP7 / 血管新生 / MSP1 / 大腸がん / 内皮細胞 / 脈管侵襲 / 消化管癌 / がん間質相互作用 |
Outline of Final Research Achievements |
In cell culture, by adding MMP7 and TGF-beta1, human cultured fibroblasts and umbilical vein endothelial cells were altered. In particular, the endothelial-endothelial junction decreased by MMP7. Therefore, it was suggested that cancer stroma around MMP7-producing tumor cells influenced the infiltration of tumor cell into vessels and promotes vascular invasion. We performed immunohistochemical staining of MSR1, a marker of macrophages associated with MMP7-related angiogenesis, for colorectal carcinoma with early hematogenous metastasis. The expression of MSR1 was observed in macrophages around cancer cells at invasive front of carcinoma. MMP7 expression of cancer cells was observed mainly in invasive front. Therefore, it was suggested that MMP7-positive cancer cells invade in vessels in association with the presence of macrophages.
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Report
(5 results)
Research Products
(1 results)