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Analysis of microenvironment for vascular and lymphatic invasion at invasive front of colorectal carcinoma

Research Project

Project/Area Number 25460423
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Human pathology
Research InstitutionToho University

Principal Investigator

FUKASAWA Yuri  東邦大学, 医学部, 講師 (90392331)

Co-Investigator(Kenkyū-buntansha) 石川 由起雄  東邦大学, 医学部, 客員教授 (30276894)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords大腸癌 / bFGF / VEGF / MMP7 / 血管新生 / MSP1 / 大腸がん / 内皮細胞 / 脈管侵襲 / 消化管癌 / がん間質相互作用
Outline of Final Research Achievements

In cell culture, by adding MMP7 and TGF-beta1, human cultured fibroblasts and umbilical vein endothelial cells were altered. In particular, the endothelial-endothelial junction decreased by MMP7. Therefore, it was suggested that cancer stroma around MMP7-producing tumor cells influenced the infiltration of tumor cell into vessels and promotes vascular invasion.
We performed immunohistochemical staining of MSR1, a marker of macrophages associated with MMP7-related angiogenesis, for colorectal carcinoma with early hematogenous metastasis. The expression of MSR1 was observed in macrophages around cancer cells at invasive front of carcinoma. MMP7 expression of cancer cells was observed mainly in invasive front. Therefore, it was suggested that MMP7-positive cancer cells invade in vessels in association with the presence of macrophages.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (1 results)

All 2016

All Presentation (1 results)

  • [Presentation] 乳房Paget病における血管新生メカニズムの分子病理学的解析2016

    • Author(s)
      深澤由里、本間尚子、緒方英昭、赤坂喜清、三上哲夫
    • Organizer
      第105回日本病理学会総会
    • Place of Presentation
      仙台国際センター(宮城県・仙台市)
    • Year and Date
      2016-05-14
    • Related Report
      2015 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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