| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
To clarify the factors related to chemoresistance of non-small cell lung cancer (NSCLC), histopathological, molecular pathological, and gene polymorphism studies were performed. Histopathologically, high nuclear grade was correlated with resistance to adjuvant chemotherapy in lung adenocarcinoma. Molecular pathological analyses revealed lower expression of mir-451 was correlated to the resistance. We also analysed immunohistochemical expressions of Keap1 and Nrf2 proteins, which are involved in detoxification of chemotherapeutic reagents in lung adenocarcinoma. The immunohistochemical study confirmed inverse expressions of these proteins. As mir-17-92 cluster was hypothesized to target the Keap1/Nrf2 system, the genetic polymorphisms of target sequence were searched with the database for Keap1/Nrf2-related genes. The genotyping data of the cases are under correaltion analyses between chemoresistance, status of Keap1/Nrf2 system, and expressions of mir-17-92 cluster in NSCLC.
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