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New stratification of malignant lymphoma from the point of view of the cancer-initiating cells

Research Project

Project/Area Number 25460435
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Human pathology
Research InstitutionOsaka University

Principal Investigator

IKEDA JUNICHIRO  大阪大学, 医学(系)研究科(研究院), 准教授 (20379176)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords癌 / 悪性リンパ腫 / 腫瘍幹細胞 / 病理学 / アルデヒド脱水素酵素 / 活性酸素 / FoxO3a / ID1 / ホジキンリンパ腫
Outline of Final Research Achievements

Cells with cancer initiating cell character in Hodgkin lymphoma have a high expression of the transcription factor FoxO3a which regulate enzymes to degrade reactive oxygen species. We examined the expression of FoxO3a in malignant lymphoma cases. FoxO3a expression was often observed in nodular sclerosis classical Hodgkin lymphoma, and FoxO3a expression was inversely correlated with the inhibitor of DNA binding (ID) protein 1 expression. The expression of FoxO3a and ID1 could be regulated by Epstein-Barr virus (EBV)-encoded latent membrane protein 1. These results suggested that the relationship between FoxO3a and ID1 through EBV infection might play an important role in tumorigenesis of Hodgkin lymphoma.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (46 results)

All 2016 2015 2014 2013 Other

All Journal Article (16 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 15 results,  Acknowledgement Compliant: 9 results,  Open Access: 6 results) Presentation (29 results) (of which Invited: 1 results) Book (1 results)

  • [Journal Article] Red Blood Cell Coagulation Induced by Low-temperature Plasma Treatment.2016

    • Author(s)
      Miyamoto K, Ikehara S, Takei H, Akimoto Y, Sakakita H, Ishikawa K, Ueda M, Ikeda J, Yamagishi M, Kim J, Yamaguchi T, Nakanishi H, Shimizu N, Hori M, Ikehara Y.
    • Journal Title

      Arch Biochem Biophys

      Volume: in press Pages: 95-101

    • DOI

      10.1016/j.abb.2016.03.023

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Requirement of CXCL12-CXCR7 signaling for CD20- CD138- double-negative population in lymphoplasmacytic lymphoma.2016

    • Author(s)
      Wada N, Ikeda J, Nojima S, Tahara S, Ohshima K, Okuzaki D, Morii E.
    • Journal Title

      Lab Invest.

      Volume: 96 Issue: 5 Pages: 517-525

    • DOI

      10.1038/labinvest.2016.28

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Prognostic significance of a component of Hippo pathway, TAZ, in human endometrioid adenocarcinoma of uterus2016

    • Author(s)
      Zhan M, Ikeda J, Wada N, Hori Y, Nojima S, Tahara S, Ueda Y, Yoshino K, Kimura T, Morii E.
    • Journal Title

      Oncol Lett

      Volume: in press

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Plasma blood coagulation without involving the activation of platelets and coagulation factors.2015

    • Author(s)
      Ikehara S, Sakakita H, Ishikawa K, Yamaguchi T, Kim J, Ueda M, Ikeda J, Nakanishi H, Shimizu N, Hori M, Ikehara Y.
    • Journal Title

      Plasma Process Polym

      Volume: 12 Issue: 12 Pages: 1348-1353

    • DOI

      10.1002/ppap.201500132

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Anti-Cancer Effects of Nonequilibrium Atmospheric Pressure Plasma on Cancer-Initiating Cells in Human Endometrioid Adenocarcinoma Cells.2015

    • Author(s)
      Ikeda J, Tsuruta Y, Nojima S, Sakakita H, Hori M, Ikehara Y.
    • Journal Title

      Plasma Process Polym.

      Volume: 12 Issue: 12 Pages: 1370-1376

    • DOI

      10.1002/ppap.201500097

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epithelioid Rhabdomyosarcoma; A case report with immunohistochemical and molecular study.2015

    • Author(s)
      Jokoji R, Ikeda J, Tsujimoto M, Morii E.
    • Journal Title

      Diagn Pathol

      Volume: 10 Issue: 1 Pages: 124-124

    • DOI

      10.1186/s13000-015-0349-2

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Poorly differentiated hepatocellular carcinoma accompanied by anti-Hu antibody-positive paraneoplastic peripheral neuropathy.2015

    • Author(s)
      Matsui T, Hori Y, Nagano H, Eguchi H, Marubashi S, Wada H, Wada N, Ikeda J, Sakamoto M, Morii E.
    • Journal Title

      Pathol Int.

      Volume: 65 Issue: 7 Pages: 388-392

    • DOI

      10.1111/pin.12304

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] mLST8 promotes mTOR-mediated tumor progression.2015

    • Author(s)
      Kakumoto K, Ikeda J, Okada M, Morii E, Oneyama C.
    • Journal Title

      PLoS ONE

      Volume: -

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Bronchogenic cyst in the chin region.2015

    • Author(s)
      Nishibayashi A, Kubo T, Matsuda K, Ikeda JI, Hosokawa K.
    • Journal Title

      J Dermatol

      Volume: - Issue: 5 Pages: 544-545

    • DOI

      10.1111/1346-8138.12816

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of non-equilibrium atmospheric pressure plasma on cancer initiating cells.2014

    • Author(s)
      Ikeda J.
    • Journal Title

      Plasma Medicine

      Volume: 4 Issue: 1-4 Pages: 49-56

    • DOI

      10.1615/plasmamed.2014011935

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Roles of histamine on the expression of aldehyde dehydrogenase 1 in endometrioid adenocarcinoma cell line.2014

    • Author(s)
      Wang Y, Jiang Y, Ikeda J, Tian T, Sato A, Ohtsu H, Morii E .
    • Journal Title

      Cancer Medicine

      Volume: 3 Issue: 5 Pages: 1126-1135

    • DOI

      10.1002/cam4.296

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Characterization of subpopulation lacking both B-cell and plasma cell markers in Waldenstrom macroglobulinemia cell line.2014

    • Author(s)
      Wada N, Zhan M, Hori Y, Honma K, Ikeda J, Morii E.
    • Journal Title

      Lab Invest.

      Volume: 94 Issue: 1 Pages: 79-88

    • DOI

      10.1038/labinvest.2013.129

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] MiR-424/503-mediated Rictor upregulation promotes tumor progression2013

    • Author(s)
      Oneyama C, Kito Y, Asai R, Ikeda J, Yoshida T, Okuzaki D, Kokuda R, Kakumoto K, Takayama K, Inoue S, Morii E, Okada M.
    • Journal Title

      PLos ONE 2013

      Volume: 8(11) Issue: 11 Pages: e80300-e80300

    • DOI

      10.1371/journal.pone.0080300

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effect of Nodal on the expression of aldehyde dehydrogenase 1 in endometrioid adenocarcinoma of uterus.2013

    • Author(s)
      Wang Y, Jiang Y, Tian T, Hori Y, Wada N, Ikeda J, Morii E.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 440 Issue: 4 Pages: 731-736

    • DOI

      10.1016/j.bbrc.2013.09.139

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Expression of FoxO3a in clinical cases of malignant lymphoma.2013

    • Author(s)
      Ikeda J, Tian T, Wang Y, Hori Y, Honma K, Wada N, Morii E.
    • Journal Title

      Pathol Res Pract.

      Volume: 209 Issue: 11 Pages: 716-720

    • DOI

      10.1016/j.prp.2013.08.003

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] ホジキンリンパ腫における小型腫瘍細胞と造腫瘍能2013

    • Author(s)
      池田 純一郎,森井 英一
    • Journal Title

      Cytometry Research

      Volume: 23 Pages: 11-14

    • NAID

      10031161827

    • Related Report
      2013 Research-status Report
  • [Presentation] 大気圧プラズマを用いたがん幹細胞の制御ーがん治療への応用に向けてー2016

    • Author(s)
      池田 純一郎
    • Organizer
      日本学術振興会153委員会 プラズマ材料科学スクール「プラズマ医療の基礎と応用」
    • Place of Presentation
      弘済会館(東京)
    • Year and Date
      2016-02-08
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 鼻腔腫瘍の1例2015

    • Author(s)
      城光寺龍,岡安唯,赤羽誉,辻本正彦,池田純一郎,森井英一
    • Organizer
      第70回日本病理学会近畿支部学術集会
    • Place of Presentation
      関西医科大学
    • Year and Date
      2015-09-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] プラズマ培養液(PAM)を用いた抗腫瘍効果と腫瘍幹細胞への影響2015

    • Author(s)
      池田 純一郎
    • Organizer
      新学術領域研究「プラズマ医療科学の創成」+「統合的神経機能の制御を標的とした糖鎖の作動原理解明」合同公開シンポジウム
    • Place of Presentation
      名古屋大学
    • Year and Date
      2015-08-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] 肺腺癌のEGFR遺伝子変異の有無と細胞所見2015

    • Author(s)
      長友忠相,川嶋真由美,内藤賢郎,¬辻洋美,野島聡,堀由美子,和田直樹,池田純一郎,南雲サチ子,森井英一
    • Organizer
      第56回日本臨床細胞学会総会(春期大会)
    • Place of Presentation
      くにびきメッセ・松江テルサ
    • Year and Date
      2015-06-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] 子宮体癌の細胞診における漿液性腺癌の特徴と臨床所見の検討2015

    • Author(s)
      松崎聖子,吉野潔,堀由美子,高田友美,上田豊,和田直樹,池田純一郎,藤田征巳,森井英一
    • Organizer
      第56回日本臨床細胞学会総会(春期大会)
    • Place of Presentation
      くにびきメッセ・松江テルサ
    • Year and Date
      2015-06-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] Epithelioid Rhabdomyosarcomaの1例2015

    • Author(s)
      城光寺龍,辻本正彦,池田純一郎,森井英一
    • Organizer
      第104回日本病理学会総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-05-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 悪性リンパ腫における未分化状態を維持する因子の検討2015

    • Author(s)
      池田純一郎.和田直樹,野島聡.田原紳一郎,森井英一
    • Organizer
      第104回日本病理学会総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-04-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] リンパ形質細胞リンパ腫におけるCD20陰性CD138陰性細胞群2015

    • Author(s)
      和田直樹,戦茂生,堀由美子,本間圭一郎,野島聡,田原紳一郎,池田純一郎,森井英一
    • Organizer
      第104回日本病理学会総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-04-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] 抗Hu抗体陽性腫瘍随伴性末梢神経障害を伴った低分化型肝細胞癌の一例2015

    • Author(s)
      松井崇浩,堀由美子,和田直樹,池田純一郎,森井英一
    • Organizer
      第104回日本病理学会総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-04-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] 背景の子宮壁内にリンパ脈管筋腫症と伴ったポリープ状のPEComaの一例2015

    • Author(s)
      堀由美子,廣瀬勝俊,小林栄仁,辻洋美,野島聡,和田直樹,池田純一郎,豊澤悟,森井英一
    • Organizer
      第104回日本病理学会総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-04-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] TREATMENT STRATEGY OF CANCER INITIATING CELLS WITH NON-EQUILIBRIUM ATOMOSPHERIC PRESSURE PLASMA2015

    • Author(s)
      池田 純一郎
    • Organizer
      The 2nd International Workshop on Plasma For Cancer Treatment (IWPCT)
    • Place of Presentation
      名古屋大学ES館1階ESホー ル
    • Year and Date
      2015-03-16 – 2015-03-17
    • Related Report
      2014 Research-status Report
  • [Presentation] 診断に苦慮した膵腫瘤の一例2014

    • Author(s)
      前野悦子,吉村英雄,堀由美子,和田直樹,池田純一郎,森井英一
    • Organizer
      第53回日本臨床細胞学会秋期大会
    • Place of Presentation
      下関市民会館・海峡メッセ下関・下関市生涯学習プラザ
    • Year and Date
      2014-11-09
    • Related Report
      2014 Research-status Report
  • [Presentation] Paxillin を標的とするmiR-27b を介したSrc によるがん悪性化の制御2014

    • Author(s)
      浅井麗伊、奥崎大介、池田純一郎、森井英一、岡田雅人、小根山千歳
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-25
    • Related Report
      2014 Research-status Report
  • [Presentation] 子宮類内膜腺癌細胞株におけるアルデヒド脱水素酵素発現に対するヒスタミンの役割2014

    • Author(s)
      池田純一郎、森井英一、大津浩
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-25
    • Related Report
      2014 Research-status Report
  • [Presentation] 大気圧プラズマを用いた腫瘍幹細胞の制御と抗腫瘍効果2014

    • Author(s)
      池田 純一郎
    • Organizer
      新学術領域研究「プラズマ医療科学の創成」第3回公開シンポジウム
    • Place of Presentation
      名古屋大学ES館1階ESホー ル
    • Year and Date
      2014-08-09
    • Related Report
      2014 Research-status Report
  • [Presentation] 腫瘍幹細胞の観点に立脚した大気圧プラズマの抗腫瘍効果の検討2014

    • Author(s)
      池田 純一郎
    • Organizer
      第18回 応用物理学会 プラズマエレクトロニクス分科会 プラズマ新領域研究会 プラズマ技術研究会
    • Place of Presentation
      名古屋大学東山キャンパスIB電子情報館 東棟2階 大講義室
    • Year and Date
      2014-06-14
    • Related Report
      2014 Research-status Report
  • [Presentation] 子宮体部漿液性腺癌32例における子宮頸部細胞診と臨床所見の検討2014

    • Author(s)
      松崎聖子,吉野潔,堀由美子,高田友美,上田豊,和田直樹,池田純一郎,藤田征巳,森井英一
    • Organizer
      第55回日本臨床細胞学会総会(春期大会)
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-06-07
    • Related Report
      2014 Research-status Report
  • [Presentation] Effect of non-equilibrium atmospheric pressure plasma in cancer initiating cells2014

    • Author(s)
      池田 純一郎
    • Organizer
      5th International Conference on Plasma Medicine (ICPM5)
    • Place of Presentation
      奈良県新公会堂
    • Year and Date
      2014-05-20
    • Related Report
      2014 Research-status Report
  • [Presentation] 子宮類内膜腺癌細胞株のアルデヒド脱水素酵素活性におけるヒスタミンの役割2014

    • Author(s)
      池田純一郎,森井英一,大津浩
    • Organizer
      第103回日本病理学会総会
    • Place of Presentation
      ANAクラウンプラザホテル広島
    • Year and Date
      2014-04-26
    • Related Report
      2014 Research-status Report
  • [Presentation] 血管新生因子AGGF1 の種々の血管病変における発現2014

    • Author(s)
      堀由美子,戦茂生,和田直樹,波多祐紀,大須賀慶悟,池田純一郎,森井英一
    • Organizer
      第103回日本病理学会総会
    • Place of Presentation
      広島国際会議場
    • Year and Date
      2014-04-25
    • Related Report
      2014 Research-status Report
  • [Presentation] 子宮体部原発神経内分泌癌の1 例2014

    • Author(s)
      辻洋美,堀由美子,野島聡,和田直樹,池田純一郎,森井英一
    • Organizer
      第103回日本病理学会総会
    • Place of Presentation
      広島国際会議場
    • Year and Date
      2014-04-25
    • Related Report
      2014 Research-status Report
  • [Presentation] 眼窩に生じたJuvenile Ossifying Fibroma の一例2014

    • Author(s)
      野田百合,本間圭一郎,野島聡,堀由美子,和田直樹,池田純一郎,豊澤悟,森井英一
    • Organizer
      第103回日本病理学会総会
    • Place of Presentation
      広島国際会議場
    • Year and Date
      2014-04-25
    • Related Report
      2014 Research-status Report
  • [Presentation] ワルデンストローム・マクログロブリン血症(WM)におけるCD20(-)CD138(-)細胞の意義2014

    • Author(s)
      和田直樹,戦茂生,堀由美子,本間圭一郎,池田純一郎,森井英一
    • Organizer
      第103回日本病理学会総会
    • Place of Presentation
      ANAクラウンプラザホテル広島
    • Year and Date
      2014-04-24
    • Related Report
      2014 Research-status Report
  • [Presentation] 悪性リンパ腫における活性酸素を制御する因子の検討

    • Author(s)
      池田 純一郎,森井 英一
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      ロイトン札幌,札幌芸文館
    • Related Report
      2013 Research-status Report
  • [Presentation] microRNA を介したmTORC2 制御とがん形質発現

    • Author(s)
      小根山千歳,鬼頭頼子,浅井麗伊,角元恭子,奥崎大介,池田純一郎,森井英一,岡田雅人
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] 後腹膜嚢胞性病変を形成したリンパ脈管筋腫症(LAM)の一例

    • Author(s)
      前野悦子,吉村英雄,堀由美子,和田直樹,池田純一郎,森井英一
    • Organizer
      第52回日本臨床細胞学会秋期大会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] 気管支擦過細胞診標本における良性異型細胞と軽度異型腺癌細胞との鑑別

    • Author(s)
      二瓶恵,吉村英雄,堀由美子,和田直樹,池田純一郎,森井英一
    • Organizer
      第52回日本臨床細胞学会秋期大会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] 腫瘍幹細胞の観点に立脚したプラズマ技術を用いた新たな腫瘍制御

    • Author(s)
      池田 純一郎
    • Organizer
      「プラズマ医療科学の創成」第2回公開シンポジウム
    • Place of Presentation
      名古屋大学IB電子情報館
    • Related Report
      2013 Research-status Report
  • [Presentation] 腫瘍幹細胞の観点に立脚したプラズマ技術を用いた新たな腫瘍制御

    • Author(s)
      池田 純一郎
    • Organizer
      プラズマ医療科学研究会
    • Place of Presentation
      秋保温泉 ホテル華乃湯
    • Related Report
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    • Author(s)
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    • Total Pages
      164
    • Publisher
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    • Related Report
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Published: 2014-07-25   Modified: 2019-07-29  

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