New stratification of malignant lymphoma from the point of view of the cancer-initiating cells
| Project/Area Number |
25460435
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Osaka University |
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Principal Investigator |
IKEDA JUNICHIRO 大阪大学, 医学(系)研究科(研究院), 准教授 (20379176)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 癌 / 悪性リンパ腫 / 腫瘍幹細胞 / 病理学 / アルデヒド脱水素酵素 / 活性酸素 / FoxO3a / ID1 / ホジキンリンパ腫 |
|---|
| Outline of Final Research Achievements |
Cells with cancer initiating cell character in Hodgkin lymphoma have a high expression of the transcription factor FoxO3a which regulate enzymes to degrade reactive oxygen species. We examined the expression of FoxO3a in malignant lymphoma cases. FoxO3a expression was often observed in nodular sclerosis classical Hodgkin lymphoma, and FoxO3a expression was inversely correlated with the inhibitor of DNA binding (ID) protein 1 expression. The expression of FoxO3a and ID1 could be regulated by Epstein-Barr virus (EBV)-encoded latent membrane protein 1. These results suggested that the relationship between FoxO3a and ID1 through EBV infection might play an important role in tumorigenesis of Hodgkin lymphoma.
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Report
(4 results)
Research Products
(46 results)
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[Journal Article] Red Blood Cell Coagulation Induced by Low-temperature Plasma Treatment2016
Author(s)
Miyamoto K, Ikehara S, Takei H, Akimoto Y, Sakakita H, Ishikawa K, Ueda M, Ikeda J, Yamagishi M, Kim J, Yamaguchi T, Nakanishi H, Shimizu N, Hori M, Ikehara Y.
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Journal Title
Arch. Biochem. Biophys.
Volume: in press
Pages: 95-101
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Prognostic significance of a component of Hippo pathway, TAZ, in human endometrioid adenocarcinoma of uterus2016
Author(s)
Zhan M, Ikeda J, Wada N, Hori Y, Nojima S, Tahara S, Ueda Y, Yoshino K, Kimura T, Morii E.
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Journal Title
Oncol Lett
Volume: in press
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Plasma Blood Coagulation Without Involving the Activation of Platelets and Coagulation Factors2015
Author(s)
Ikehara S, Sakakita H, Ishikawa K, Yamaguchi T, Kim J, Ueda M, Ikeda J, Nakanishi H, Shimizu N, Hori M, Ikehara Y.
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Journal Title
Plasma Processes and Polymers.
Volume: 12
Pages: 1348-1353
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] MiR-424/503-mediated Rictor upregulation promotes tumor progression.2013
Author(s)
Oneyama C, Kito Y, Asai R, Ikeda J, Yoshida T, Okuzaki D, Kokuda R, Kakumoto K, Takayama K, Inoue S, Morii E, Okada M.
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Journal Title
DOI
Related Report
Peer Reviewed
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