Pathological Analysis for Lung Adenocarcinomas with KRAS Mutations and Strong Proliferating Activity (in Association with S100 Proteins)

• Project/Area Number: 25460441
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Yokohama City University
• Principal Investigator: WOO Tetsukan 横浜市立大学, 医学(系)研究科(研究院), 客員研究員 (90537177)
• Co-Investigator(Kenkyū-buntansha): OKUDELA Koji 横浜市立大学, 医学部, 准教授 (10326027) ; OHASHI Kenichi 横浜市立大学, 医学(系)研究科(研究院), 教授 (40231203) ; MASUDA Munetaka 横浜市立大学, 医学(系)研究科(研究院), 教授 (10190365) ; ARAI Hiromasa 横浜市立大学, 医学(系)研究科(研究院), 客員講師 (10381493)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 肺癌 / KRAS / 増殖活性 / S100

Outline of Final Research Achievements

We previously reported that patients with lung adenocarcinomas with KRAS gene mutations and strong proliferating activity had poorer outcomes and some S100 molecules were up-regulated by the oncogenic KRAS. The present study examined surgically resected primary lung adenocarcinomas for the expression of some S100 proteins, and analyzed the potential relationships between their levels and clinicopathologic factors. The results demonstrated that S100A11 expression levels were significantly higher in adenocarcinomas with KRAS mutations and strong proliferating activity. The results suggest that S100A11 plays a role in tumor progression, particularly in lung adenocarcinomas with KRAS mutations and strong proliferating activity.

Research Products

• [Journal Article] Expression of tropomyosins in lung cancer - a potential role in carcinogenesis and its utility in a histopathological diagnosis. (2016)
  • Author(s): Okudela K, Mitsui H, Woo T, Kojima Y, Matsumura M, Arai H, Suzuki T, Umeda S, Tateishi Y, Saito Y, Tajiri M, Masuda M, Kameda Y, Ohashi K
  • Journal Title: Histology and Histopathology Volume: 31
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Up-Regulation of S100A11 in Lung Adenocarcinoma - Its Potential Relationship with Cancer Progression. (2015)
  • Author(s): Woo T, Okudela K, Mitsui H, Tajiri M, Rino Y, Ohashi K, Masuda M
  • Journal Title: PLoS One Volume: 10 Issue: 11 Pages: e0142642-e0142642
  • DOI: 10.1371/journal.pone.0142642
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Pre-operative chemotherapy for non-small cell lung carcinoma (2015)
  • Author(s): Horita N, Woo T, Miyazawa N, Kaneko T
  • Journal Title: Transl Lung Cancer Res Volume: 4(1) Pages: 8-14
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Allelic imbalance in the miR-31 host gene locus in lung cancer-its potential role in carcinogenesis (2014)
  • Author(s): Okudela K, Tateishi Y, Umeda S, Mitsui H, Suzuki T, Saito Y, Woo T, Tajiri M, Masuda M, Miyagi Y, Ohashi K
  • Journal Title: PLoS One Volume: 9(6) Issue: 6 Pages: e100581-e100581
  • DOI: 10.1371/journal.pone.0100581
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Comparison between CT tumor size and pathological tumor size in frozen section examinations of lung adenocarcinoma (2014)
  • Author(s): Isaka T, Yokose T, Ito H, Imamura N, Watanabe M, Imai K, Nishii T, Woo T,Yamada K, Nakayama H, Masuda M
  • Journal Title: Lung Cancer Volume: 85(1) Issue: 1 Pages: 40-46
  • DOI: 10.1016/j.lungcan.2014.03.023
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Proteome analysis for downstream targets of oncogenic KRAS--the potential participation of CLIC4 in carcinogenesis in the lung. (2014)
  • Author(s): Okudela K, Katayama A, Woo T, Mitsui H, Suzuki T, Tateishi Y, Umeda S, Tajiri M, Masuda M, Nagahara N, Kitamura H and Ohashi K
  • Journal Title: PLoS One Volume: 9 Issue: 2 Pages: 1-10
  • DOI: 10.1371/journal.pone.0087193
  • Peer Reviewed / Open Access
• [Journal Article] Expression of HDAC9 in lung cancer-potential role in lung carcinogenesis. (2013)
  • Author(s): Okudela K, Mitsui H, Suzuki T, Woo T, Tateishi Y, Umeda S, Saito Y, Tajiri M, Masuda M, Ohashi K.
  • Journal Title: Int J Clin Exp Pathol. Volume: 7(1) Pages: 213-20
  • Peer Reviewed
• [Presentation] 悪性胸膜中皮腫診断におけるp16 FISHの有用性 (2016)
  • Author(s): 禹 哲漢、岩城秀行、長知樹、乾健二、益田宗孝
  • Organizer: 第33回日本呼吸器外科学会総会
  • Place of Presentation: 国立京都国際会館（京都府京都市）
  • Year and Date: 2016-05-13
• [Presentation] Up-Regulation of S100A11 in Lung Adenocarcinoma - Its Potential Relationship with Cancer Progression. (2016)
  • Author(s): 禹 哲漢、岩城 秀行、長 知樹、古波藏 かおり、田尻 道彦、益田 宗孝
  • Organizer: 第116回日本外科学会定期学術集会
  • Place of Presentation: リーガロイヤルホテル大阪（大阪府大阪市）
  • Year and Date: 2016-04-16
• [Presentation] Oligometastasis肺癌における循環・遊離癌細胞 (2016)
  • Author(s): 禹 哲漢
  • Organizer: ILO (International Lung Clinical Research Organization) ワークショップ
  • Place of Presentation: 愛知県立がんセンター（愛知県名古屋市）
  • Year and Date: 2016-02-27
• [Presentation] StageI肺腺癌における癌幹細胞マーカーの予後予測指標としての有用性 (2014)
  • Author(s): 禹哲漢
  • Organizer: 第31回日本呼吸器外科学会総会
  • Place of Presentation: ホテル日航東京（東京都）
  • Year and Date: 2014-05-29 – 2014-05-30
• [Presentation] 非小細胞肺癌術前導入治療の効果判定におけるFDG-PET/CT の有用性―CT との比較―． (2013)
  • Author(s): 禹哲漢
  • Organizer: 第30回日本呼吸器外科学会
  • Place of Presentation: 名古屋国際会議場（愛知県）
• [Presentation] StageI肺腺癌におけるIASLC/ATS/ERS分類の予後予測指標としての有用性． (2013)
  • Author(s): 禹哲漢
  • Organizer: 第66回日本胸部外科学会定期学術集会
  • Place of Presentation: 仙台国際センター（宮城県）