Pathological Analysis for Lung Adenocarcinomas with KRAS Mutations and Strong Proliferating Activity (in Association with S100 Proteins)
Project/Area Number |
25460441
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Human pathology
|
Research Institution | Yokohama City University |
Principal Investigator |
WOO Tetsukan 横浜市立大学, 医学(系)研究科(研究院), 客員研究員 (90537177)
|
Co-Investigator(Kenkyū-buntansha) |
OKUDELA Koji 横浜市立大学, 医学部, 准教授 (10326027)
OHASHI Kenichi 横浜市立大学, 医学(系)研究科(研究院), 教授 (40231203)
MASUDA Munetaka 横浜市立大学, 医学(系)研究科(研究院), 教授 (10190365)
ARAI Hiromasa 横浜市立大学, 医学(系)研究科(研究院), 客員講師 (10381493)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 肺癌 / KRAS / 増殖活性 / S100 |
Outline of Final Research Achievements |
We previously reported that patients with lung adenocarcinomas with KRAS gene mutations and strong proliferating activity had poorer outcomes and some S100 molecules were up-regulated by the oncogenic KRAS. The present study examined surgically resected primary lung adenocarcinomas for the expression of some S100 proteins, and analyzed the potential relationships between their levels and clinicopathologic factors. The results demonstrated that S100A11 expression levels were significantly higher in adenocarcinomas with KRAS mutations and strong proliferating activity. The results suggest that S100A11 plays a role in tumor progression, particularly in lung adenocarcinomas with KRAS mutations and strong proliferating activity.
|
Report
(4 results)
Research Products
(13 results)
-
[Journal Article] Expression of tropomyosins in lung cancer - a potential role in carcinogenesis and its utility in a histopathological diagnosis.2016
Author(s)
Okudela K, Mitsui H, Woo T, Kojima Y, Matsumura M, Arai H, Suzuki T, Umeda S, Tateishi Y, Saito Y, Tajiri M, Masuda M, Kameda Y, Ohashi K
-
Journal Title
Histology and Histopathology
Volume: 31
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
[Journal Article] Allelic imbalance in the miR-31 host gene locus in lung cancer-its potential role in carcinogenesis2014
Author(s)
Okudela K, Tateishi Y, Umeda S, Mitsui H, Suzuki T, Saito Y, Woo T, Tajiri M, Masuda M, Miyagi Y, Ohashi K
-
Journal Title
PLoS One
Volume: 9(6)
Issue: 6
Pages: e100581-e100581
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
[Journal Article] Comparison between CT tumor size and pathological tumor size in frozen section examinations of lung adenocarcinoma2014
Author(s)
Isaka T, Yokose T, Ito H, Imamura N, Watanabe M, Imai K, Nishii T, Woo T,Yamada K, Nakayama H, Masuda M
-
Journal Title
Lung Cancer
Volume: 85(1)
Issue: 1
Pages: 40-46
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
[Journal Article] Proteome analysis for downstream targets of oncogenic KRAS--the potential participation of CLIC4 in carcinogenesis in the lung.2014
Author(s)
Okudela K, Katayama A, Woo T, Mitsui H, Suzuki T, Tateishi Y, Umeda S, Tajiri M, Masuda M, Nagahara N, Kitamura H and Ohashi K
-
Journal Title
PLoS One
Volume: 9
Issue: 2
Pages: 1-10
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-