| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Well-differentiated liposarcoma(WLPS) and dedifferentiated liposarcoma(DLPS) are characterized by MDM2 gene amplification and resultant protein overexpression. In this study we examined cytogenetic, mRNA and protein status of MDM2 using a novel approach of simultaneous visualization of morphology, cytogenetic and molecular abnormalities. Although MDM2 abnormalities were only observed in a subset of tumor cells, clonal selection and condensation of these abnormal cells was occurred during dedifferentiation process, concurrently with loss of adipocytic differentiation. Present study may provide a new information useful for pathological diagnosis of liposarcomas as well as future molecular targeted therapy using MDM2 inhibitors.
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