Mechanisms of IgA producing B cell production in tonsillar lesions with IgA nephropathy
Project/Area Number |
25460451
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Human pathology
|
Research Institution | Yamagata University |
Principal Investigator |
|
Research Collaborator |
MENG Hongxue
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
|
Keywords | IgA腎症 / 扁桃組織 / 胚中心 / 濾胞樹状細胞 / IgA / TSLP / AID / TRLP receptor / AICD |
Outline of Final Research Achievements |
The present study firstly demonstrated that tonsillar follicular dendritic cells of IgA nephropathy patients express thymic stromal lymphopoietin (TSLP) and its receptor, and the TSLP-TSLPR interaction promotes IgA class switching through the cooperative role of transforming growth factor-β1, B cell-activating factor of the tumor necrosis factor family, a proliferation-inducing ligand and activation-induced cytidine deaminase.
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Report
(4 results)
Research Products
(64 results)
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Goto N, Tsurumi H, Takami T, Futamura M, Morimitsu K, Takata K, Sato Y, Yoshino T, Adachi S, Saito K, Yamakawa M.
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Am J Surg Pathol.
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[Journal Article] Immunoglobulin and CD8-positive T-cell distribution in histologically distinctive tonsils of individuals with tonsillar focal infection2015
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Meng HX, Ohe R, Li HN, Yang SR, Kabasawa T, Kato T, Zhang L, Ohtake H, Ishida A, Ohta N, Jin XM, Kakehata S, Yamakawa M
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Acta Otolaryngol
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Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Decreased expression of follicular dendritic cell-secreted protein correlates with increased immunoglobulin A production in the tonsils of individuals with immunoglobulin A nephropathy2015
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Meng HX, Li HN, Geng JS, Ohe R, Yu XY, E XQ, Ye F, Yang SR, Kato T, Zhang L, Ishida A, Ohta N, Jin XM, Kakehata S, Geng JS
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Transl Res
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[Journal Article] Kidney fibrosis is independent of the amount of ascorbic acid in mice with unilateral ureteral obstruction2014
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Nishida H, Kurahashi T, Saito Y, Otsuki N, Kwon M, Ohtake H, Yamakawa M, Yamada K, Miyata S, Tomita Y, Fujiia J
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第55回日本リンパ網内系学会総会
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Year and Date
2015-07-11
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Year and Date
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Year and Date
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