Study of a novel therapy of the triple-negative breast cancers (TNBC) -based on DNA copy number aberration.
Project/Area Number |
25460458
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Human pathology
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Research Institution | Yamaguchi University |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | トリプルネガティブ乳癌 / ゲノム異常 / イメージサイトメトリー / 細胞周期 / 乳癌 / トリプルネガティブ / 分子標的薬 |
Outline of Final Research Achievements |
Triple-negative breast cancer (TNBC) is refractory breast cancer because specific therapies are not establieshed. We focused on interferon gamma (IFN-gamma) which is located in the genomic loss region exclusively in TNBC and investigated the effect of INF-gamma on TNBC in vitro. Several cell lines derived from TNBC were inhibited cell proliferation by IFN-gamma. However, one cell line from TNBC was not inhibited. INF-gamma altered the cell cycle and the expression levels of some cell-cylce associated proteins in TNBC cell lines. The pattens of change in the expression leves of theses proteins were different in cell lines. This suggest that IFN-gamma arrest cell cycles via several pathway in TNBC.
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Report
(5 results)
Research Products
(11 results)
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[Journal Article] DN多型2013
Author(s)
末広 寛、古屋 智子、佐々木 功典、日野田 裕治
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Journal Title
日本臨床検査医学会誌
Volume: 61
Pages: 1001-1007
Related Report
Peer Reviewed
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[Journal Article] Germline copy number variations associated with breast cancer susceptibility in a Japanese population.2013
Author(s)
Suehiro Y, Okada T, Shikamoto N, Zhan Y, Sakai K, Okayama N, Nishioka M, Furuya T, Oga A, Kawauchi S, Maeda N, Tamesa M, Nagashima Y, Yamamoto S, Oka M, Hinoda Y, Sasaki K
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Journal Title
Tumour Biol
Volume: 34(2)
Issue: 2
Pages: 947-952
DOI
Related Report
Peer Reviewed
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