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Study of a novel therapy of the triple-negative breast cancers (TNBC) -based on DNA copy number aberration.

Research Project

Project/Area Number 25460458
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Human pathology
Research InstitutionYamaguchi University

Principal Investigator

KONOD-FURUYA Tomoko  山口大学, 医学(系)研究科(研究院), 講師 (30379979)

Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsトリプルネガティブ乳癌 / ゲノム異常 / イメージサイトメトリー / 細胞周期 / 乳癌 / トリプルネガティブ / 分子標的薬
Outline of Final Research Achievements

Triple-negative breast cancer (TNBC) is refractory breast cancer because specific therapies are not establieshed. We focused on interferon gamma (IFN-gamma) which is located in the genomic loss region exclusively in TNBC and investigated the effect of INF-gamma on TNBC in vitro. Several cell lines derived from TNBC were inhibited cell proliferation by IFN-gamma. However, one cell line from TNBC was not inhibited. INF-gamma altered the cell cycle and the expression levels of some cell-cylce associated proteins in TNBC cell lines. The pattens of change in the expression leves of theses proteins were different in cell lines. This suggest that IFN-gamma arrest cell cycles via several pathway in TNBC.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (11 results)

All 2016 2015 2014 2013

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (5 results)

  • [Journal Article] がん細胞のタンパク質情報を考慮に入れた、SVMによる病理診断システムの可能性2015

    • Author(s)
      北風裕教、重本昌也、古屋智子、松野浩嗣
    • Journal Title

      産業応用工学会論文誌

      Volume: 3 Pages: 56-64

    • NAID

      130005263502

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Analysis of centromere signal patterns in breast cancer cells with chromosomal instability using image cytometry combined with centromere fluorescence in situ hybridization.2014

    • Author(s)
      Ito H, Oga A, Ikemoto K, Furuya T, Maeda N, Yamamoto S, Kawauchi S, Itoh H, Oka M, Sasaki K.
    • Journal Title

      Cytometry A

      Volume: 85 Issue: 9 Pages: 809-816

    • DOI

      10.1002/cyto.a.22502

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] DN多型2013

    • Author(s)
      末広 寛、古屋 智子、佐々木 功典、日野田 裕治
    • Journal Title

      日本臨床検査医学会誌

      Volume: 61 Pages: 1001-1007

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Quantitative analysis of centrromeric FISH spots during the cell cycle by image cytometry2013

    • Author(s)
      Amakawa G, Ikemoto K, Ito H, Furuya T, Sasaki K
    • Journal Title

      J Histochem Cytochem

      Volume: 61 Issue: 10 Pages: 699-705

    • DOI

      10.1369/0022155413498754

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Elucidation of proliferative capability of mononuclear tetraploid cells, emerging spontaneously from diploid cells, using image cytometry and fluorescence in situ hybridization.2013

    • Author(s)
      Ito H, Oga A, Furuya T, Ikemoto K, Amakawa G, Chochi Y, Kawauchi S, Sasaki K
    • Journal Title

      Cell Prolif

      Volume: 46(3) Issue: 3 Pages: 356-363

    • DOI

      10.1111/cpr.12032

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Germline copy number variations associated with breast cancer susceptibility in a Japanese population.2013

    • Author(s)
      Suehiro Y, Okada T, Shikamoto N, Zhan Y, Sakai K, Okayama N, Nishioka M, Furuya T, Oga A, Kawauchi S, Maeda N, Tamesa M, Nagashima Y, Yamamoto S, Oka M, Hinoda Y, Sasaki K
    • Journal Title

      Tumour Biol

      Volume: 34(2) Issue: 2 Pages: 947-952

    • DOI

      10.1007/s13277-012-0630-x

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 病理組織の分子遺伝学的解析によるゲノム変化と臨床病態との関連について2016

    • Author(s)
      古屋智子
    • Organizer
      第105回日本病理学会
    • Place of Presentation
      仙台国際センター(宮城県・仙台市)
    • Year and Date
      2016-05-12
    • Related Report
      2016 Annual Research Report
  • [Presentation] イメージサイトメーターを用いたインターフェロンγの細胞増殖抑制効果に関する研究2015

    • Author(s)
      古屋智子、伊藤秀明、北風裕教、小賀厚徳、松野浩嗣、佐々木功典、伊藤浩史
    • Organizer
      日本サイトメトリー学術集会
    • Place of Presentation
      ソラシティカンファレンスセンター(東京都千代田区)
    • Year and Date
      2015-07-11
    • Related Report
      2015 Research-status Report
  • [Presentation] インターフェロンガンマの乳癌由来培養細胞への影響についての細胞周期的解析2015

    • Author(s)
      近藤(古屋)智子、原田美沙、伊藤秀明、帖地康代、小賀厚徳、河内茂人、佐々木功典、伊藤浩史
    • Organizer
      第104回 日本病理学会総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-04-30 – 2015-05-02
    • Related Report
      2014 Research-status Report
  • [Presentation] イメージサイトメトリーを用いた染色体不安定性の解析2013

    • Author(s)
      伊藤 秀明、小賀 厚徳、古屋 智子、池本 健三、帖地 康世、佐々木 功典、河内 茂人
    • Organizer
      日本病理学会総会
    • Place of Presentation
      ロイトン札幌 札幌芸文館 (札幌市)
    • Related Report
      2013 Research-status Report
  • [Presentation] ヒト骨髄由来間葉系幹細胞の長期培養におけるゲノム変化ついての検討2013

    • Author(s)
      古屋 智子、伊藤 秀明、帖地 康世、池本 健三、小賀 厚徳、河内 茂人、佐々木 功典
    • Organizer
      日本病理学会総会
    • Place of Presentation
      ロイトン札幌 札幌芸文館 (札幌市)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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