Does the balance in lymphoma of immunity become the prognostic factor of cancer?
| Project/Area Number |
25460460
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Kumamoto University |
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Principal Investigator |
horlad hasita 熊本大学, その他の研究科, 研究員 (00644840)
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| Co-Investigator(Kenkyū-buntansha) |
Komohara Yoshihiro 熊本大学, 大学院生命科学研究部, 準教授 (40449921)
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| Co-Investigator(Renkei-kenkyūsha) |
Takeya Motohiro 熊本大学, 大学院生命科学研究部, 教授 (90155052)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | マクロファージ / CD169 / リンパ節 |
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| Outline of Final Research Achievements |
We previously demonstrated that macrophage activation status in regional lymph node was significantly associated with anti-tumor immune responses and clinical course. In this study project we tried to investigate if similar results were seen in malignant melanoma and pancreatic cancer, and we found that cases which CD169-positive macrophages are increased in regional lymph node showed better clinical prognosis in melanoma and pancreatic cancer. In addition to this research project, we tried to do research of TIM-3 in malignant lymphoma and renal cell carcinoma. The density of TIM-3-positive-macrophages are well correlated with worse clinical prognosis in clear cell renal cell carcinoma. TIM-3 expression in lymphoma cells were well correlated to the chemo-resistance in adult T-cell leukemia/lymphoma.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Prognostic significance of CD169+ lymph node sinus macrophages in patients with malignant melanoma.2015
Author(s)
Saito Y, Ohnishi K, Miyashita A, Nakahara S, Fujiwara Y, Horlad H, Motoshima T, Fukushima S, Jinnin M, Ihn H, Takeya M, Komohara Y.
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Journal Title
Cancer Immunol Res
Volume: 3
Pages: 1356-1363
Related Report
Peer Reviewed
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[Journal Article] The coordinated actions of TIM-3 on cancer and myeloid cells in the regulation of tumorigenicity and clinical prognosis in clear cell renal cell carcinomas.2015
Author(s)
Komohara Y, Morita T, Annan DA, Horlad H, Ohnishi K, Yamada S, Nakayama T, Kitada S, Suzu S, Kinoshita I, Dosaka-Akita H, Akashi K, Takeya M, Jinushi M.
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Journal Title
Cancer Immunol Res
Volume: 3
Pages: 999-1007
Related Report
Peer Reviewed
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