| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Outline of Final Research Achievements |
An extensive look into TNFAIP3/A20 exon 3 domain of 582 patient’s suffering from inflammatory diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjogren syndrome (SjS) and others revealed the presence of an F127C mutation which has identified in the same disease populations abroad. While significant association to SLE, this F127C SNP was not found in RA or SjS patients in Oita.
The odds ratio (OR) of F127C SNP in patients versus healthy subjects was 2.08 in Oita and OR was 1.37 in European population. In the case of SLE patients the OR was 6.25 and it was 4.77 fold higher than those in Europa (OR: 1.31). These findings suggest F127C occurrence could play an important role in inflammatory disease onset, specifically in SLE, in the Japanese population.
|
