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Distinct pathogenic properties in A20-F127C SNPs between European and Japanese populations

Research Project

Project/Area Number 25460461
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Human pathology
Research InstitutionOita University

Principal Investigator

IHA Hidekatsu  大分大学, 医学部, 准教授 (50242631)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
KeywordsTAX1BP1 / TNFAIP3/A20 / inflammatory diseases / SNPs / SLE / 一塩基多型 / A20/TNFAIP3 / 炎症疾患 / 炎症性疾患
Outline of Final Research Achievements

An extensive look into TNFAIP3/A20 exon 3 domain of 582 patient’s suffering from inflammatory diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjogren syndrome (SjS) and others revealed the presence of an F127C mutation which has identified in the same disease populations abroad. While significant association to SLE, this F127C SNP was not found in RA or SjS patients in Oita.
The odds ratio (OR) of F127C SNP in patients versus healthy subjects was 2.08 in Oita and OR was 1.37 in European population. In the case of SLE patients the OR was 6.25 and it was 4.77 fold higher than those in Europa (OR: 1.31). These findings suggest F127C occurrence could play an important role in inflammatory disease onset, specifically in SLE, in the Japanese population.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (9 results)

All 2015 2014 2013

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (5 results) Book (1 results)

  • [Journal Article] Establishment of new predictive markers for distant recurrence of colorectal cancer using lectin microarray analysis2015

    • Author(s)
      Nakajima K, N.Shiraishi, et al.
    • Journal Title

      Cancer Med.

      Volume: 4(2) Issue: 2 Pages: 293-302

    • DOI

      10.1002/cam4.342

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Commensal microbiota contributes to chronic endocarditis in TAX1BP1 deficient mice.2013

    • Author(s)
      Nakano S, Ikebe E, Tsukamoto Y, Wang Y, Matsumoto T, Mitsui T, Yahiro T, Inoue K, Kawazato H, Yasuda A, Ito K, Yokoyama S, Takahashi N, Hori M, Shimada T, Moriyama M, Kubota T, Ono K, Fujibuchi W, Jeang KT, Iha H, Nishizono A.
    • Journal Title

      PLoS One

      Volume: 8(9) Issue: 9 Pages: e73205-e73205

    • DOI

      10.1371/journal.pone.0073205

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Oral administration of an HSP90 inhibitor, 17-DMAG, intervenes tumor-cell infiltration into multiple organs and improves survival period for ATL model mice.2013

    • Author(s)
      Ikebe E, Kawaguchi A, Tezuka K, et al
    • Journal Title

      Blood Cancer Journal

      Volume: 3 Issue: 8 Pages: e132-e132

    • DOI

      10.1038/bcj.2013.30

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Distinct pathogenic properties in A20-F127C SNPs between European and Japanese populations2015

    • Author(s)
      Iha Hidekatsu, Fife Nichole, Ikebe Emi, Matsumoto Takashi, Ishii Koji, Ogata Masao, Imai Hiromitsu, Takahashi Naohiko, Kubota Toshiaki, Kawano Masanori, Eshima Nobuoki, Ueyama Shigehiro, Ishida Yoichi, Nishizono Akira
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      札幌コンベンションセンター(北海道、札幌)
    • Year and Date
      2015-11-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Comparison of pathogenic properties in A20-F127C SNPs for inflammatory diseases between European and Japanese populations.2015

    • Author(s)
      Fife Nichole, Ikebe Emi, Matsumoto Takashi, Ishii Koji, Ogata Masao, Imai Hiromitsu, Takahashi Naohiko, Kubota Toshiaki, Kawano Masanori, Eshima Nobuoki, Ueyama Shigehiro, Ishida Yoichi, Nishizono Akira, Iha Hidekatsu
    • Organizer
      第2回日本HTLV-1学会学術集会
    • Place of Presentation
      東京大学医科学研究所(東京都、港区)
    • Year and Date
      2015-08-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] Linkage between single nucleotide polymorphisms of A20-exon3 and various inflammatory diseases: a study in Oita prefecture.2014

    • Author(s)
      FIFE Nichole, IKEBE Emi, ISHII Koji, OGATA Masao, IMAI Hiromitsu, TAKAHASHI Naohiko, KUBOTA Toshiaki, NISHIZONO Akira, IHA Hidekatsu
    • Organizer
      第43回日本免疫学会学術集会
    • Place of Presentation
      国立京都国際会館、京都府、京都市
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Research-status Report
  • [Presentation] Linkage between single nucleotide polymorphisms of A20-exon3 and various inflammatory diseases: a study in Oita prefecture.2014

    • Author(s)
      FIFE Nichole, IKEBE Emi, ISHII Koji, OGATA Masao, IMAI Hiromitsu, TAKAHASHI Naohiko, KUBOTA Toshiaki, NISHIZONO Akira, IHA Hidekatsu
    • Organizer
      第1回日本HTLV-1学会学術集会
    • Place of Presentation
      東京大学医科学研究所、東京、港区
    • Year and Date
      2014-08-22 – 2014-08-24
    • Related Report
      2014 Research-status Report
  • [Presentation] Linkage between TAX1BP1 polymorphism and inflammatory diseases2013

    • Author(s)
      NAKANO Satoko, AOYAGI Youko, FIFE Nichole, MIZUTANI, Yuki, ISHII Koji, TAKAHASHI Naohiko, KUBOTA Toshiaki, NISHIZONO Akira, IHA Hidekatsu
    • Organizer
      日本免疫学会
    • Place of Presentation
      幕張メッセ(千葉県、千葉市)
    • Related Report
      2013 Research-status Report
  • [Book] T-Cell Leukemia - Characteristics, Treatment and Prevention2013

    • Author(s)
      Iha Hidekatsu, Yamada Masao
    • Total Pages
      139
    • Publisher
      InTech Press
    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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