| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Adaptation of the additional operation after the endoscopic treatment for the early gastric cancer was determined by histopathological diagnosis. Standardization of histopathological diagnostic criteria for submucosal invasive gastric carcinoma have been particularly important problem. In this study, the following results were revealed. 1) The morphological changes of the muscularis mucosae were histologically divided into complete maintenance type, discontinuous and ill-defined structure type and complete destruction type. 2) The morphological types of muscularis mucosae were related to clinicopathologic characteristics such as macroscopic feature, submucosal invasion depth, main histologic type of submucosal invasion area, mucin phenotype, lymphovascular invasion and lymph node metastasis. 3) The use of whole-slide imaging in histologic evaluation was possible like a conventional light microscopy and was usuful for standardization of histopathologic diagnostic criteria.
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