Study on standardization of histopathological diagnostic criteria for submucosal invasive gastric carcinoma

• Project/Area Number: 25460463
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Iwate Medical University
• Principal Investigator: ISHIDA KAZUYUKI 岩手医科大学, 医学部, 准教授 (40444004)
• Co-Investigator(Kenkyū-buntansha): SUGAI TAMOTSU 岩手医科大学医学部, 病理診断学講座, 教授 (20187628)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 胃粘膜下層浸潤癌 / 病理組織診断 / 粘膜筋板 / 浸潤距離 / 標準化 / バーチャルスライド / 病理学 / 人体病理学 / 胃粘膜下浸潤癌 / 粘膜筋板の形状 / 粘膜下層浸潤距離 / 内視鏡治療

Outline of Final Research Achievements

Adaptation of the additional operation after the endoscopic treatment for the early gastric cancer was determined by histopathological diagnosis. Standardization of histopathological diagnostic criteria for submucosal invasive gastric carcinoma have been particularly important problem. In this study, the following results were revealed. 1) The morphological changes of the muscularis mucosae were histologically divided into complete maintenance type, discontinuous and ill-defined structure type and complete destruction type. 2) The morphological types of muscularis mucosae were related to clinicopathologic characteristics such as macroscopic feature, submucosal invasion depth, main histologic type of submucosal invasion area, mucin phenotype, lymphovascular invasion and lymph node metastasis. 3) The use of whole-slide imaging in histologic evaluation was possible like a conventional light microscopy and was usuful for standardization of histopathologic diagnostic criteria.

Research Products

• [Journal Article] Clinicopathological and molecular alterations in early gastric cancers with the microsatellite instability-high phenotype (2016)
  • Author(s): Sugimoto R, Sugai T, Habano W, Endoh M, Eizuka M, Yamamoto E, Uesugi N, Ishida K, Kawasaki T, Matsumoto T, Suzuki H.
  • Journal Title: Int J Cancer Volume: 1 Issue: 7 Pages: 1689-97
  • DOI: 10.1002/ijc.29916
  • Peer Reviewed / Open Access
• [Journal Article] Proposal for novel histological findings of colorectal liver metastases with preoperative chemotherapy (2015)
  • Author(s): Ishida K, Uesugi N, Hasegawa Y, Sugimoto R, Takahara T, Otsuka K, Nitta H, Kawasaki T, Wakabayashi G, Sugai T
  • Journal Title: Pathol Int Volume: 65 Issue: 7 Pages: 367-73
  • DOI: 10.1111/pin.12300
  • NAID: 120006644554
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Alpha-fetoprotein: A biomarker for the recruitment of progenitor cells in the liver in patients with acute liver injury or failure. (2015)
  • Author(s): Kakisaka K, Kataoka K, Onodera M, Suzuki A, Endo K, Tatemichi Y, Kuroda H, Ishida K, Takikawa Y
  • Journal Title: Hepatol Res Volume: 45 Issue: 10 Pages: 12-20
  • DOI: 10.1111/hepr.12448
  • NAID: 120005867728
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Significance of a white opaque substance under magnifying narrow-band imaging colonoscopy for the diagnosis of colorectal epithelial neoplasms. (2015)
  • Author(s): Kawasaki K, Kurahara K, Yanai S, Oshiro Y, Eizuka M, Uesugi N, Ishida K, Nakamura S, Fuchigami T, Sugai T, Matsumoto T.
  • Journal Title: Gastrointest Endosc. Volume: 82(6) Issue: 6 Pages: 1097-1104
  • DOI: 10.1016/j.gie.2015.06.023
  • Peer Reviewed
• [Journal Article] Molecular analysis of isolated tumor glands from endometrial endometrioid adenocarcinomas. (2015)
  • Author(s): Suga Y, Sugai T, Uesugi N, Kawasaki T, Fukagawa T, Yamamoto E, Ishida K, Suzuki H, Sugiyama T.
  • Journal Title: Pathol Int Volume: 65 Issue: 5 Pages: 240-249
  • DOI: 10.1111/pin.12274
  • Peer Reviewed / Open Access
• [Journal Article] Clinicopathological features and surgical outcomes of adenosquamous carcinoma of the pancreas: a retrospective analysis of patients with resectable stage tumors. (2015)
  • Author(s): Komatsu H, Egawa S, Motoi F, Morikawa T, Sakata N, Naitoh T, Katayose Y, Ishida K, Unno M.
  • Journal Title: Surg Today Volume: 45 Issue: 3 Pages: 297-304
  • DOI: 10.1007/s00595-014-0934-0
  • Peer Reviewed
• [Journal Article] Eosinophilic granulomatosis with polyangiitis involving the small intestine: radiographic and endoscopic findings. (2015)
  • Author(s): Kawasaki K, Eizuka M, Murata O, Ishida K, Nakamura S, Sugai T, Matsumoto T.
  • Journal Title: Endoscopy Volume: 47(S 01) Issue: S 01 Pages: 492-494
  • DOI: 10.1055/s-0034-1393140
  • Peer Reviewed / Open Access
• [Presentation] 膵腫瘍 (2016)
  • Author(s): 石田 和之．
  • Organizer: 第105回日本病理学会総会（病理診断講習会）
  • Place of Presentation: 仙台
  • Year and Date: 2016-05-12
  • Invited
• [Presentation] 膵疾患の病理診断 ～疾患の理解と診断のポイント～． (2015)
  • Author(s): 石田 和之．
  • Organizer: 第51回日本医学放射線学会秋季臨床大会（リフレッシャーコース6）
  • Place of Presentation: 盛岡
  • Year and Date: 2015-10-02
  • Invited
• [Presentation] 大腸癌肝転移巣における組織評価とPET/CTの比較検討． (2015)
  • Author(s): 石田 和之，加藤 健一，長谷川 康，上杉 憲幸，川島 和哉，高橋 弥生，永塚 真，高原 武志，新田 浩幸，大塚 幸喜，川崎 朋範，菅井 有．
  • Organizer: 第51回日本肝癌研究会
  • Place of Presentation: 神戸
  • Year and Date: 2015-07-23
• [Presentation] 臍帯血幹細胞移植後に消化管生検を行った1例 (2015)
  • Author(s): 石田 和之，杉本 亮，小宅 達郎，梁井 俊一，佐藤 綾香，土田 宏大，荒川 典之，永塚 真，深川 智之，高橋 弥生，菅 安寿子，鈴木 正通，無江 良晴，上杉 憲幸，川崎 朋範，菅井 有．
  • Organizer: 第81回日本病理学会東北支部学術集会
  • Place of Presentation: 弘前
  • Year and Date: 2015-07-04
• [Presentation] IFALD/PNACの病態 Intestinal failure-associated liver disease (IFALD) の病理像 小腸不全，小腸移植症例の検討． (2015)
  • Author(s): 石田 和之，和田 基，工藤 博典，柿坂 啓介，藤島 史喜，仁尾 正記，菅井 有．
  • Organizer: 日本外科代謝栄養学会第52回学術集会（日本小児外科代謝研究会jointシンポジウム）
  • Place of Presentation: 東京
  • Year and Date: 2015-07-02
• [Presentation] プロトコール生検の必要性について考える プロトコール生検の組織像の実際． (2015)
  • Author(s): 石田 和之．
  • Organizer: 第51回日本移植学会総会（イブニングセミナー）
  • Place of Presentation: 神戸
  • Year and Date: 2015-05-28
  • Invited
• [Presentation] 大腸癌肝転移巣における組織像とPET-CTとの比較． (2015)
  • Author(s): 石田 和之，上杉 憲幸，山田 範幸，杉本 亮，鈴木 正通，無江 良晴，川崎 朋範，菅井 有．
  • Organizer: 第104回日本病理学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-04-30
• [Presentation] 粘膜筋板の形状から見た胃pSM癌の臨床病理学的検討 (2014)
  • Author(s): 小坂崇，石田和之，他
  • Organizer: 第103回日本病理学会総会
  • Place of Presentation: 広島
• [Presentation] 胃粘膜下層浸潤癌（SM癌）の浸潤距離測定方法の検討 (2013)
  • Author(s): 佐藤綾香，石田和之，他
  • Organizer: 第102回日本病理学会総会
  • Place of Presentation: 札幌