Histopathological approach for early invasive breast carcinoma
| Project/Area Number |
25460467
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
Moriya Takuya 川崎医科大学, 医学部, 教授 (00230160)
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| Co-Investigator(Kenkyū-buntansha) |
KUREBAYASHI JUNICHI 川崎医科大学, 医学部, 教授 (10248255)
SUZUKI TAKASHI 東北大学, 医学系研究科, 教授 (10261629)
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| Co-Investigator(Renkei-kenkyūsha) |
KANOMATA NAOKI 川崎医科大学, 医学部, 准教授 (60263373)
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| Research Collaborator |
NAKANO TOMOHIRO
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 病理 / 乳癌 / 浸潤 / 間質 / 早期癌 / 初期浸潤 / 免疫組織化学 / 病理診断学 / 乳腺 / 非浸潤癌 / 浸潤癌 / 病理学 / 人体病理学 / 免疫組織染色 / 診断病理学 / 筋上皮細胞 / 基質 |
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| Outline of Final Research Achievements |
Clinicopathological analysis of early invasive carcinomas of the breast had been performed. The criteria of invasion may not be consistent among expert pathologists using ordinal staining specimen, so immunohistochemical approach against myoepithelial cells should be recommended. The proportion of histological classification and intrinsic subtype among early invasive carcinoma (maximum invasive diameter 5mm or less) were similar to those of invasive carcinoma in general, but different from non-invasive carcinoma. The expression of integrin αｖβ6 may be the indicator for invasiveness, for non-invasive stage of carcinogenesis. In addition, uPAR and PAI-1 were related to degradation of basement membrane at pre-invasive stage, and MMP was expressed at early invasive stage. However, it was suggested that not all of breast carcinomas may progress the same manner, and further investigation will be necessary.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Assessment of the Ki67 labeling index: a Japanese validation ring study.2014
Author(s)
Niikura N, Sakatani T, Arima N, Ohi Y, Honma N, Kanomata N, Yoshida K, Kadoya T, Tamaki K, Kumaki N, Iwamoto T, Sugie T, Moriya T
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Journal Title
Breast Cancer
Volume: 21
Issue: 1
Pages: 1-9
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 当院での色素法単独によるセンチネルリンパ節生検,特に近傍の非染色リンパ節の転移状況に関する検討2014
Author(s)
平川久,甘利正和,岡きまこ,木村道夫,武田元博,森谷卓也,渡辺みか,笠島敦子,秋保信彦,長嶋真紀
Organizer
第22回日本乳癌学会学術総会
Place of Presentation
大阪府 大阪市 大阪国際会議場
Year and Date
2014-07-11
Related Report
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[Presentation] 乳頭・乳輪温存乳房切除術後の局所再発リスク因子の検討2014
Author(s)
山下哲正,紅林淳一,齋藤亙,太田裕介,小池良和,下登志朗,山本裕,田中克浩,鹿股直樹,森谷卓也,緒方良平,川野汐織,森彩子
Organizer
第22回日本乳癌学会学術総会
Place of Presentation
大阪府 大阪市 大阪国際会議場
Year and Date
2014-07-10
Related Report
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[Presentation] 乳癌のKi67(MIB-1)1,000個数えてますか?簡単な目測判定(eye-5)は、labeling index(LI)の代用となる2014
Author(s)
飛田陽, 坂東健次, 杉田敦郎, 前田智治, 植田規史, 松影昭一, 中西護, 西村理恵子, 木藤克己, 宮崎龍彦, 大朏祐治, 大城由美, 森谷卓也
Organizer
第103回日本病理学会総会
Place of Presentation
広島県 広島市 広島国際会議場
Year and Date
2014-04-25
Related Report
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