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Pathological classification of the pituitary adenoma reflecting prognosis and therapeutic sensitivity.

Research Project

Project/Area Number 25460468
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Human pathology
Research InstitutionOkinaka Memorial Institute for Medical Research

Principal Investigator

Inoshita Naoko  公益財団法人冲中記念成人病研究所, その他部局等, 研究員 (20300741)

Co-Investigator(Kenkyū-buntansha) FUJII Takeshi  冲中記念成人病研究所, 研究員 (70228948)
Co-Investigator(Renkei-kenkyūsha) YAMADA Shozo  冲中記念成人病研究所, 研究員
NISHIOKA Hiroshi  冲中記念成人病研究所, 研究員
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords下垂体腺腫 / 内分泌腫瘍 / 病理組織学 / 免疫染色 / 下垂体 / 内分泌 / 病理診断 / 病理組織学的検討 / 電子顕微鏡
Outline of Final Research Achievements

Pituitary tumors are endocrine tumors. Half of these tumors cause a serious endocrine abnormalities, including Cushing's disease, gigantism, and acromegaly. The remaining half are non-functional tumors exhibiting severe neurological symptoms by the invasive and massive growth. Although pituitary tumor is a rare disease , we have the accumulation of many cases in our hospital, and continue to investigate clinical and pathological findings.
In the present study period, 1) was carried out re-classification of hormone staining negative non-functional adenomas, at the point of clinical findings, prognosis, and pathological study, and 2) clinicopathological study of pituitary adenomas with Cushing 's disease.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (20 results)

All 2016 2015 2014 2013

All Journal Article (11 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Acknowledgement Compliant: 2 results,  Open Access: 2 results) Presentation (8 results) (of which Int'l Joint Research: 1 results,  Invited: 5 results) Book (1 results)

  • [Journal Article] The USP8 mutational status may predict drug susceptibility in corticotroph adenomas of Cushing's disease.2016

    • Author(s)
      Hayashi, K., Inoshita, N., Kawaguchi, K., Ardisasmita, A.I., Suzuki, H., Fukuhara, N., Okada, M., Nishioka, H., Takeuchi, Y., Komada, M., Takeshita, A., and Yamada, S.
    • Journal Title

      Eur. J. Endocrinol.

      Volume: 174 Issue: 2 Pages: 213-226

    • DOI

      10.1530/eje-15-0689

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 2.The Complementary Role of Transcription Factors in the Accurate Diagnosis of Clinically Nonfunctioning Pituitary Adenomas.2015

    • Author(s)
      Nishioka H, Inoshita N, Mete O, Asa SL, Hayashi K, Takeshita A, Fukuhara N, Takeuchi Y, Yamada S
    • Journal Title

      Endocrine pathology

      Volume: 26(4) Issue: 4 Pages: 349-355

    • DOI

      10.1007/s12022-015-9398-z

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 3.Therapeutic outcomes in patients undergoing surgery after diagnosis of Cushing’s disease: A single-center study.2015

    • Author(s)
      Yamada S, Inoshita N, Fukuhara N, Yamaguchi-Okada M,Nishioka H, Takeshita A, Suzuki H, Ito J, and Takeuchi Y
    • Journal Title

      Endocrine journal

      Volume: 62 Pages: 21-27

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 【臨床医に必要な内分泌疾患の病理学】ACTH産生下垂体腺腫 病理2015

    • Author(s)
      井下尚子
    • Journal Title

      内分泌・糖尿病・代謝内科

      Volume: 40 Pages: 340-344

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 下垂体病理(解説)2014

    • Author(s)
      井下尚子
    • Journal Title

      Progress in Medicine

      Volume: 46 Pages: 422-427

    • Related Report
      2014 Research-status Report
  • [Journal Article] 下垂体2014

    • Author(s)
      井下尚子
    • Journal Title

      病理と臨床 臨時増刊号 免疫組織化学 診断と治療選択の指針

      Volume: 32 Pages: 210-213

    • Related Report
      2014 Research-status Report
  • [Journal Article] A Novel C-terminal Nonsense Mutation, Q315X, of the Aryl Hydrocarbon Receptor-Interacting Protein Gene in a Japanese Familial Isolated Pituitary Adenoma Family.2014

    • Author(s)
      Iwata T.
    • Journal Title

      Endocrine Journal

      Volume: Epub ahead of print

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 下垂体ナルセル腺腫の臨床病理学的検討2013

    • Author(s)
      西岡 宏
    • Journal Title

      日本内分泌学会雑誌

      Volume: 89 Pages: 29-30

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 妊娠を契機に増大して尿崩症を来したプロラクチノーマの1例2013

    • Author(s)
      岡崎 瑞穂
    • Journal Title

      Progress in Medicine

      Volume: 33巻11号 Pages: 2540-2541

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 異所性silent ACTH産生下垂体腺腫の1例2013

    • Author(s)
      福原 紀章
    • Journal Title

      日本内分泌学会雑誌

      Volume: 89 Pages: 8-10

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinicopathological Features of Growth Hormone-Producing Pituitary Adenomas in 242 Acromegaly Patients: Classification according to Hormone Production and Cytokeratin Distribution.2013

    • Author(s)
      Mori R.
    • Journal Title

      ISRN Endocrinol

      Volume: Epub 2013 Pages: 1-8

    • DOI

      10.1155/2013/723432

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Slide seminar endocrine pathology, pituitary2015

    • Author(s)
      Naoko Inoshita
    • Organizer
      APIAP
    • Place of Presentation
      Brisbane
    • Year and Date
      2015-06-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Pituitary, slide seminar2014

    • Author(s)
      Naoko Inoshita, Shozo Yamada
    • Organizer
      IAP 2014
    • Place of Presentation
      Thailand
    • Year and Date
      2014-10-09
    • Related Report
      2014 Research-status Report
  • [Presentation] トルコ鞍近傍腫瘍の病理2014

    • Author(s)
      井下尚子
    • Organizer
      第32回脳腫瘍病理学会
    • Place of Presentation
      徳島
    • Year and Date
      2014-05-23
    • Related Report
      2014 Research-status Report
  • [Presentation] 内分泌病理から臨床へのフィードバック 下垂体腫瘍の病理組織像 臨床所見との対比へ2014

    • Author(s)
      井下 尚子
    • Organizer
      第87回内分泌学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-04-26
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 内分泌病理から臨床へのフィードバック 下垂体疾患2014

    • Author(s)
      井下尚子
    • Organizer
      第87回日本内分泌学会学術総会
    • Place of Presentation
      福岡
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Hormone-negative pituitary adenoma2013

    • Author(s)
      Naoko Inoshita
    • Organizer
      The 8th Asia Pacific IAP Congress
    • Place of Presentation
      Busan, Korea
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] An oncocytic corticotroph adenoma of 4th type of Cushing disease: Immunohistochemical and ultrastructual study2013

    • Author(s)
      Naoko Inoshita
    • Organizer
      The 8th Asia Pacific IAP Congress
    • Place of Presentation
      Busan, Korea
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 内分泌病理入門コース2013

    • Author(s)
      井下尚子
    • Organizer
      第17回日本内分泌病理学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Book] 免疫組織化学 診断と治療選択の指針2014

    • Author(s)
      井下尚子
    • Total Pages
      442
    • Publisher
      文光堂
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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