Expression of long noncoding RNA in lung adenocarcinoma

• Project/Area Number: 25460469
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Japanese Foundation for Cancer Research (2014-2016); 独立行政法人国立国際医療研究センター (2013)
• Principal Investigator: IIZUKA Toshihiko 公益財団法人がん研究会, がん研究所 病理部, 研究員 (80323707)
• Co-Investigator(Kenkyū-buntansha): 石川 雄一 公益財団法人がん研究会, がん研究所 病理部, 部長 (80222975)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2013: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
• Keywords: 肺癌 / long noncoding RNA

Outline of Final Research Achievements

Long noncoding RNA (lncRNA) HOTAIR epigenetically regulates the expression of various genes through recruiting the polycomb protein EZH2 to the target genome locus. We examined the expression of HOTAIR and EZH2 in 83 resected cases of lung adenocarcinoma by qRT-PCR and immunohistochemistry. We found that the expression of both genes were associated with the histological grade of adenocarcinoma and were associated with prognosis. Furthermore, we found that more accurate prediction of prognosis is possible by measuring the expression of both genes.

Research Products

• [Journal Article] hTERT promoter polymorphism, -1327C>T, is associated with the risk of epithelial cancer (2013)
  • Author(s): Iizuka T, Sawabe M, Takubo K, Liu M, Homma Y, Suzuki M, Arai T.
  • Journal Title: Springerplus Volume: 2 Issue: 1 Pages: 249-249
  • DOI: 10.1186/2193-1801-2-249
  • Peer Reviewed
• [Presentation] 肺腺癌および周囲肺組織における長鎖非コードRNA MALAT-1の発現 (2016)
  • Author(s): 飯塚利彦、長野裕子、野村紀美恵、石川雄一
  • Organizer: 第105回日本病理学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2016-05-12
• [Presentation] 肺腺癌での長鎖非コードRNA HOTAIRおよびポリコーム蛋白質EZH2の発現 - 組織像、予後との関連 (2015)
  • Author(s): 飯塚利彦、 石川雄一
  • Organizer: 第17回日本RNA学会年会
  • Place of Presentation: 札幌
  • Year and Date: 2015-07-15
• [Presentation] 肺腺癌におけるlncRNA MALAT-1の発現とKRAS変異の関連 (2014)
  • Author(s): 飯塚利彦、長野裕子、野村紀美恵、元井紀子、奥村栄、石川雄一
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] 肺腺癌における長鎖noncoding RNA MALAT-1の発現とKRAS変異の関連 (2014)
  • Author(s): 飯塚利彦、長野裕子、野村紀美恵、元井紀子、石川雄一
  • Organizer: 第103回日本病理学会総会
  • Place of Presentation: 広島
  • Year and Date: 2014-04-24 – 2014-04-26
• [Presentation] 肺腺癌における長鎖 noncoding RNA MALAT-1の発現とKRAS変異の関連 (2014)
  • Author(s): 飯塚利彦、長野裕子、野村起美恵、元井紀子、石川雄一
  • Organizer: 日本病理学会総会
  • Place of Presentation: 広島